Speed of Information Processing in Patients with Multiple Sclerosis

2003 ◽  
Vol 20 (4) ◽  
pp. 98-106 ◽  
Author(s):  
Robert Kail
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Speed Of Information Processing

Lateral Interactions and Speed of Information Processing in Highly Functioning Multiple Sclerosis Patients

2007 ◽  
Vol 20 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Helga Nagy ◽  
Krisztina Bencsik ◽  
Cec??lia Rajda ◽  
Krisztina Benedek ◽  
M??rta Jan??ky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Lateral Interactions ◽  
Speed Of Information Processing ◽  
Multiple Sclerosis Patients

scholarly journals Rapid serial processing in patients with multiple sclerosis: The role of peripheral deficits

2008 ◽  
Vol 14 (4) ◽  
pp. 646-650 ◽  
Author(s):  
ANGELA M. BODLING ◽  
DOUGLAS R. DENNEY ◽  
SHARON G. LYNCH
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Progressive Multiple Sclerosis ◽  
Motor Deficits ◽  
Stimulus Information ◽  
Serial Processing ◽  
Speed Of Information Processing ◽  
Relapsing Remitting ◽  
Peripheral Motor

This study compared speed of information processing in patients with relapsing–remitting or secondary progressive multiple sclerosis (MS) and healthy controls using the Stroop Test and a Picture Naming Test (PNT). While both tests evaluated processing speed within a format calling for rapid serial processing of stimulus information, the PNT included trials designed to impose greater verbal–motor and ocular–motor challenges by using novel rather than repeated pictures and by presenting the pictures in distributed locations rather than always centered on the screen. The results confirmed that a decrease in the speed of information processing is a key feature of the cognitive impairment occurring in conjunction with MS. When this feature is evaluated with tests requiring rapid serial processing of stimulus information, the contribution of peripheral motor deficits appears to be modest. (JINS, 2008, 14, 646–650.)

scholarly journals A Pilot Study to Assess At-Home Speed of Processing Training for Individuals with Multiple Sclerosis

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Lindsay Barker ◽  
Brian C. Healy ◽  
Emily Chan ◽  
Kaitlynne Leclaire ◽  
Bonnie I. Glanz
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Executive Function ◽  
Pilot Study ◽  
Verbal Memory ◽  
Training Intervention ◽  
Speed Of Processing ◽  
Speed Of Information Processing ◽  
Patient Reported ◽  
At Home

Objective. Cognitive impairment is a common symptom of multiple sclerosis (MS), yet treatment is currently limited. The primary goal of this pilot study was to assess the feasibility and acceptability of an at-home, five-week computerized speed of processing (SOP) training intervention for MS patients. In addition, we examined the utility of the intervention to improve speed of information processing, memory, executive function, and health-related quality of life (HRQOL). Method. Fifteen subjects were assigned five weeks of SOP training, two times per week, for a total of ten sessions. Subjects were trained on five computerized SOP tasks that required processing of increasingly complex visual stimuli in successively shorter presentation times. Subjects were given a neuropsychological test battery that included measures of speed of information processing, verbal memory, visual spatial memory, and executive function. Subjects were also administered patient-reported outcome (PRO) measures to assess HRQOL, depression, and work productivity. Neuropsychological and PRO batteries were completed at baseline and after five weeks. Results. Eighty percent of subjects completed the five-week intervention (n = 12). Significant improvements were observed on some, but not all, measures of speed of information processing, verbal memory, and executive function. There were no significant changes in HRQOL. Conclusion. This pilot study supports the feasibility of an at-home SOP training intervention for individuals with MS. SOP training was associated with improvements in several cognitive domains. Larger, randomized controlled trials are warranted.

Cognitive impairment in relapsing—remitting multiple sclerosis can be predicted by imaging performed several years earlier

2007 ◽  
Vol 14 (2) ◽  
pp. 197-204 ◽  
Author(s):  
MM Summers ◽  
LK Fisniku ◽  
VM Anderson ◽  
DH Miller ◽  
L. Cipolotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Cognitive Performance ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Lesion Volume ◽  
Significant Variance ◽  
Speed Of Information Processing ◽  
Relapsing Remitting

Cognitive deficits in multiple sclerosis (MS) are common and correlate with contemporary MRI brain abnormalities, particularly atrophy, but the ability of imaging early in the disease to predict later cognitive impairment remains to be determined. Thirty relapsing—remitting MS patients recruited within three years of the onset of the disease, and in whom MRI had been performed at baseline and a year later, were assessed neuropsychologically five years later. Imaging parameters accounting for significant variance in cognitive performance were identified using multiple regressions, once confounding variables were controlled. Patients performed significantly worse than expected on tests of attention/speed of information processing and half of them had experienced some decline in IQ in relation to premorbid estimates. The rate of global brain atrophy in the first year of the study accounted for significant variance in the overall cognitive performance, and in memory and attention/speed of information processing. Poor performance on attention tests was associated with high T1-weighted lesion volume and reduced magnetization transfer ratio (MTR) in normal-appearing white matter (NAWM). These results suggest that neuroaxonal loss was identified early in the disease, and its rate of progression, predicted cognitive impairment later in the disease. Neuroaxonal loss is likely to affect commissural and association fibres that subserve the cognitive processes impaired in MS. Multiple Sclerosis 2008; 14: 197—204. http://msj.sagepub.com

Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis

2007 ◽  
Vol 13 (1) ◽  
pp. 124-127 ◽  
Author(s):  
L Feuillet ◽  
F Reuter ◽  
B Audoin ◽  
I Malikova ◽  
K Barrau ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Verbal Memory ◽  
Early Stage ◽  
Cognitive Status ◽  
Clinically Isolated Syndrome ◽  
Speed Of Information Processing ◽  
Healthy Control ◽  
Processing Language

Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.

Neuropsychological deficits in patients with chronic fatigue syndrome

2004 ◽  
Vol 10 (2) ◽  
pp. 278-285 ◽  
Author(s):  
KIM BUSICHIO ◽  
LANA A. TIERSKY ◽  
JOHN DELUCA ◽  
BENJAMIN H. NATELSON
Keyword(s):  
Information Processing ◽  
Chronic Fatigue Syndrome ◽  
Executive Functioning ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Motor Speed ◽  
Neuropsychological Dysfunction ◽  
Speed Of Information Processing ◽  
Fatigue Syndrome ◽  
Healthy Control

The degree of neuropsychological dysfunction across multiple domains was examined in individuals suffering from chronic fatigue syndrome (CFS). In this descriptive study, a similar series of neuropsychological tests was administered to a group of CFS patients and healthy participants. More specifically, CFS patients (n = 141) who met the 1994 Case Definition criteria were compared to 76 healthy control participants on tests of memory, attention (concentration), speed of information processing, motor speed, and executive functioning. On the 18 measures administered, CFS patients scored 1 standard deviation below the healthy mean on nine measures and scored 2 standard deviations below the healthy mean on four of the measures. Moreover, results indicated that CFS patients were more likely than healthy controls to fail (1.6 SD below the healthy mean) at least one test in each of the following domains: attention, speed of information processing, and motor speed, but not on measures of memory and executive functioning. Finally, CFS patients demonstrated a greater total number of tests failed across domains. (JINS, 2004, 10, 278–285.)

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