scholarly journals A Pilot Study to Assess At-Home Speed of Processing Training for Individuals with Multiple Sclerosis

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Lindsay Barker ◽  
Brian C. Healy ◽  
Emily Chan ◽  
Kaitlynne Leclaire ◽  
Bonnie I. Glanz
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Executive Function ◽  
Pilot Study ◽  
Verbal Memory ◽  
Training Intervention ◽  
Speed Of Processing ◽  
Speed Of Information Processing ◽  
Patient Reported ◽  
At Home

Objective. Cognitive impairment is a common symptom of multiple sclerosis (MS), yet treatment is currently limited. The primary goal of this pilot study was to assess the feasibility and acceptability of an at-home, five-week computerized speed of processing (SOP) training intervention for MS patients. In addition, we examined the utility of the intervention to improve speed of information processing, memory, executive function, and health-related quality of life (HRQOL). Method. Fifteen subjects were assigned five weeks of SOP training, two times per week, for a total of ten sessions. Subjects were trained on five computerized SOP tasks that required processing of increasingly complex visual stimuli in successively shorter presentation times. Subjects were given a neuropsychological test battery that included measures of speed of information processing, verbal memory, visual spatial memory, and executive function. Subjects were also administered patient-reported outcome (PRO) measures to assess HRQOL, depression, and work productivity. Neuropsychological and PRO batteries were completed at baseline and after five weeks. Results. Eighty percent of subjects completed the five-week intervention (n = 12). Significant improvements were observed on some, but not all, measures of speed of information processing, verbal memory, and executive function. There were no significant changes in HRQOL. Conclusion. This pilot study supports the feasibility of an at-home SOP training intervention for individuals with MS. SOP training was associated with improvements in several cognitive domains. Larger, randomized controlled trials are warranted.

Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosis

2011 ◽  
Vol 17 (11) ◽  
pp. 1324-1332 ◽  
Author(s):  
C Tur ◽  
S Penny ◽  
Z Khaleeli ◽  
DR Altmann ◽  
L Cipolotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Executive Function ◽  
Cognitive Performance ◽  
Verbal Memory ◽  
Visual Information ◽  
Grey Matter ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis

Objectives: To identify associations between cognitive impairment and imaging measures in a cross-sectional study of patients with primary progressive multiple sclerosis (PPMS). Methods: Neuropsychological tests were administered to 27 patients with PPMS and 31 controls. Patients underwent brain conventional magnetic resonance imaging (MRI) sequences, volumetric scans and magnetization transfer (MT) imaging; MT ratio (MTR) parameters, grey matter (GM) and normal-appearing white matter (NAWM) volumes, and WM T2 lesion load (T2LL) were obtained. In patients, multiple linear regression models identified the imaging measure associated with the abnormal cognitive tests independently from the other imaging variables. Partial correlation coefficients (PCC) were reported. Results: Patients performed worse on tests of attention/speed of visual information processing, delayed verbal memory, and executive function, and had a worse overall cognitive performance index, when compared with controls. In patients, a lower GM peak location MTR was associated with worse overall cognitive performance ( p < 0.001, PCC = 0.77). GM mean and peak height MTR showed the strongest association with the estimated verbal intelligence quotient (IQ) decline ( p < 0.001, PCC = -0.62), and executive function ( p < 0.001, PCC = 0.79). NAWM volume was associated with attention/speed of visual information processing ( p < 0.001, PCC = 0.74), while T2LL was associated with delayed verbal memory ( p = 0.007, PCC = -0.55). Conclusions: The finding of strong associations between GM MTR, NAWM volume and T2LL and specific cognitive impairments suggests that models that predict cognitive impairment in PPMS should include comprehensive MRI assessments of both GM and WM. However, GM MTR appears to be the main correlate of overall cognitive dysfunction, underlining the role of abnormal GM integrity in determining cognitive impairment in PPMS.

Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis

2007 ◽  
Vol 13 (1) ◽  
pp. 124-127 ◽  
Author(s):  
L Feuillet ◽  
F Reuter ◽  
B Audoin ◽  
I Malikova ◽  
K Barrau ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Verbal Memory ◽  
Early Stage ◽  
Cognitive Status ◽  
Clinically Isolated Syndrome ◽  
Speed Of Information Processing ◽  
Healthy Control ◽  
Processing Language

Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.

Lateral Interactions and Speed of Information Processing in Highly Functioning Multiple Sclerosis Patients

2007 ◽  
Vol 20 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Helga Nagy ◽  
Krisztina Bencsik ◽  
Cec??lia Rajda ◽  
Krisztina Benedek ◽  
M??rta Jan??ky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Lateral Interactions ◽  
Speed Of Information Processing ◽  
Multiple Sclerosis Patients

Is Speed of Processing or Working Memory the Primary Information Processing Deficit in Multiple Sclerosis?

2004 ◽  
Vol 26 (4) ◽  
pp. 550-562 ◽  
Author(s):  
John DeLuca ◽  
Gordon J. Chelune ◽  
David S. Tulsky ◽  
Jean Lengenfelder ◽  
Nancy D. Chiaravalloti
Keyword(s):  
Multiple Sclerosis ◽  
Working Memory ◽  
Information Processing ◽  
Speed Of Processing ◽  
Processing Deficit

scholarly journals Rapid serial processing in patients with multiple sclerosis: The role of peripheral deficits

2008 ◽  
Vol 14 (4) ◽  
pp. 646-650 ◽  
Author(s):  
ANGELA M. BODLING ◽  
DOUGLAS R. DENNEY ◽  
SHARON G. LYNCH
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Progressive Multiple Sclerosis ◽  
Motor Deficits ◽  
Stimulus Information ◽  
Serial Processing ◽  
Speed Of Information Processing ◽  
Relapsing Remitting ◽  
Peripheral Motor

This study compared speed of information processing in patients with relapsing–remitting or secondary progressive multiple sclerosis (MS) and healthy controls using the Stroop Test and a Picture Naming Test (PNT). While both tests evaluated processing speed within a format calling for rapid serial processing of stimulus information, the PNT included trials designed to impose greater verbal–motor and ocular–motor challenges by using novel rather than repeated pictures and by presenting the pictures in distributed locations rather than always centered on the screen. The results confirmed that a decrease in the speed of information processing is a key feature of the cognitive impairment occurring in conjunction with MS. When this feature is evaluated with tests requiring rapid serial processing of stimulus information, the contribution of peripheral motor deficits appears to be modest. (JINS, 2008, 14, 646–650.)

Moderate Caffeine Intake and Verbal Memory in Multiple Sclerosis: A Pilot Study

2016 ◽  
Vol 6 (3) ◽  
pp. 134-138
Author(s):  
Laura Segalà ◽  
Mayte Forte ◽  
Melissa R. Ortega ◽  
Silvia Delgado ◽  
Kottil Rammohan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Verbal Memory ◽  
Caffeine Intake

scholarly journals A comparison of cognitive performances between neuromyelitis optica spectrum disorder and multiple sclerosis patients in Indian context

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Swati Kumar ◽  
Goutam Gangopadhyay ◽  
Atanu Biswas ◽  
Souvik Dubey ◽  
Alak Pandit ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Executive Function ◽  
Neuromyelitis Optica ◽  
Processing Speed ◽  
Verbal Fluency ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Information Processing Speed

Abstract Background To compare the frequency and pattern of cognitive impairment in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) patients. Results Twenty NMOSD and forty MS patients were included. Clinical and detailed neuropsychological assessment was done using frontal assessment battery and Kolkata cognitive battery supplemented with additional standard tests for different domains of cognitive functions. Domain wise tests were performed and compared. 15/20 (75%) NMOSD and 32/40 (80%) MS patients had cognitive impairment (p = 0.65). Executive function, verbal fluency, information processing speed, visuo-constructional ability, attention, complex calculation, and memory were more commonly involved in NMOSD in decreasing order. Compared to MS, the pattern was similar except that verbal fluency was more impaired in NMOSD. Expanded Disability Status scale (EDSS) correlated with cognitive involvement in NMOSD (p = 0.02) as against MS. Conclusions Executive function, verbal fluencies, and information processing speed were more affected compared to visual and verbal memory in NMOSD patients. The pattern of cognitive performance was similar in the MS group, even though clinical and radiological characteristics and pathophysiology is different, suggesting similar brain involvement.

Sign in / Sign up

Export Citation Format

Share Document