Lateral Interactions and Speed of Information Processing in Highly Functioning Multiple Sclerosis Patients

2007 ◽  
Vol 20 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Helga Nagy ◽  
Krisztina Bencsik ◽  
Cec??lia Rajda ◽  
Krisztina Benedek ◽  
M??rta Jan??ky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Lateral Interactions ◽  
Speed Of Information Processing ◽  
Multiple Sclerosis Patients

scholarly journals Rapid serial processing in patients with multiple sclerosis: The role of peripheral deficits

2008 ◽  
Vol 14 (4) ◽  
pp. 646-650 ◽  
Author(s):  
ANGELA M. BODLING ◽  
DOUGLAS R. DENNEY ◽  
SHARON G. LYNCH
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Progressive Multiple Sclerosis ◽  
Motor Deficits ◽  
Stimulus Information ◽  
Serial Processing ◽  
Speed Of Information Processing ◽  
Relapsing Remitting ◽  
Peripheral Motor

This study compared speed of information processing in patients with relapsing–remitting or secondary progressive multiple sclerosis (MS) and healthy controls using the Stroop Test and a Picture Naming Test (PNT). While both tests evaluated processing speed within a format calling for rapid serial processing of stimulus information, the PNT included trials designed to impose greater verbal–motor and ocular–motor challenges by using novel rather than repeated pictures and by presenting the pictures in distributed locations rather than always centered on the screen. The results confirmed that a decrease in the speed of information processing is a key feature of the cognitive impairment occurring in conjunction with MS. When this feature is evaluated with tests requiring rapid serial processing of stimulus information, the contribution of peripheral motor deficits appears to be modest. (JINS, 2008, 14, 646–650.)

scholarly journals Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 111
Author(s):  
Ana Jerković ◽  
Meri Matijaca ◽  
Ana Proroković ◽  
Anđela Šikić ◽  
Vana Košta ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Processing Speed ◽  
Convergent Validity ◽  
Information Processing Speed ◽  
Study Objective ◽  
Medication Therapy ◽  
Control Subjects ◽  
Multiple Sclerosis Patients ◽  
The Impact

Cognitive impairment is a common complaint in people with multiple sclerosis (pwMS). The study objective was to determine the psychometric properties of the letter digit substitution test (LDST) that measures information processing speed and to investigate the impact of relevant predictors of LDST achievement in pwMS. The design was cross-sectional. The study included 87 pwMS and 154 control subjects. The validity of LDST was examined, and a hierarchical regression model was used to explore relevant predictors of LDST success. The LDST had excellent construct validity, as expressed by differences between pwMS and control subjects. Convergent validity of the LDST was supported by a significant moderate correlation with the expanded disability status scale (EDSS) (ρ = −0.36; p < 0.05) and a significantly strong correlation with the multiple sclerosis impact scale (MSIS-29) physical subscale (r = −0.64; p < 0.01). The LDTS score well differentiated the pwMS considering age, education, EDSS, disease duration, comorbidity, and medication therapy. Using the LDST as a criterion variable in pwMS results showed consistent evidence for the age, education, and EDSS impact on LDST performance. The best cut-off score of ≤35 discriminated the control and MS group. LDST proved to be a valid test for assessing information processing speed in pwMS.

scholarly journals A Pilot Study to Assess At-Home Speed of Processing Training for Individuals with Multiple Sclerosis

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Lindsay Barker ◽  
Brian C. Healy ◽  
Emily Chan ◽  
Kaitlynne Leclaire ◽  
Bonnie I. Glanz
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Executive Function ◽  
Pilot Study ◽  
Verbal Memory ◽  
Training Intervention ◽  
Speed Of Processing ◽  
Speed Of Information Processing ◽  
Patient Reported ◽  
At Home

Objective. Cognitive impairment is a common symptom of multiple sclerosis (MS), yet treatment is currently limited. The primary goal of this pilot study was to assess the feasibility and acceptability of an at-home, five-week computerized speed of processing (SOP) training intervention for MS patients. In addition, we examined the utility of the intervention to improve speed of information processing, memory, executive function, and health-related quality of life (HRQOL). Method. Fifteen subjects were assigned five weeks of SOP training, two times per week, for a total of ten sessions. Subjects were trained on five computerized SOP tasks that required processing of increasingly complex visual stimuli in successively shorter presentation times. Subjects were given a neuropsychological test battery that included measures of speed of information processing, verbal memory, visual spatial memory, and executive function. Subjects were also administered patient-reported outcome (PRO) measures to assess HRQOL, depression, and work productivity. Neuropsychological and PRO batteries were completed at baseline and after five weeks. Results. Eighty percent of subjects completed the five-week intervention (n = 12). Significant improvements were observed on some, but not all, measures of speed of information processing, verbal memory, and executive function. There were no significant changes in HRQOL. Conclusion. This pilot study supports the feasibility of an at-home SOP training intervention for individuals with MS. SOP training was associated with improvements in several cognitive domains. Larger, randomized controlled trials are warranted.

Cognitive impairment in relapsing—remitting multiple sclerosis can be predicted by imaging performed several years earlier

2007 ◽  
Vol 14 (2) ◽  
pp. 197-204 ◽  
Author(s):  
MM Summers ◽  
LK Fisniku ◽  
VM Anderson ◽  
DH Miller ◽  
L. Cipolotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Cognitive Performance ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Lesion Volume ◽  
Significant Variance ◽  
Speed Of Information Processing ◽  
Relapsing Remitting

Cognitive deficits in multiple sclerosis (MS) are common and correlate with contemporary MRI brain abnormalities, particularly atrophy, but the ability of imaging early in the disease to predict later cognitive impairment remains to be determined. Thirty relapsing—remitting MS patients recruited within three years of the onset of the disease, and in whom MRI had been performed at baseline and a year later, were assessed neuropsychologically five years later. Imaging parameters accounting for significant variance in cognitive performance were identified using multiple regressions, once confounding variables were controlled. Patients performed significantly worse than expected on tests of attention/speed of information processing and half of them had experienced some decline in IQ in relation to premorbid estimates. The rate of global brain atrophy in the first year of the study accounted for significant variance in the overall cognitive performance, and in memory and attention/speed of information processing. Poor performance on attention tests was associated with high T1-weighted lesion volume and reduced magnetization transfer ratio (MTR) in normal-appearing white matter (NAWM). These results suggest that neuroaxonal loss was identified early in the disease, and its rate of progression, predicted cognitive impairment later in the disease. Neuroaxonal loss is likely to affect commissural and association fibres that subserve the cognitive processes impaired in MS. Multiple Sclerosis 2008; 14: 197—204. http://msj.sagepub.com

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