Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts

2003 ◽  
Vol 82 (11) ◽  
pp. 565-571 ◽  
Author(s):  
Cecilia Berg ◽  
Catarina Trofast ◽  
Torbjörn Bengtsson
Keyword(s):  
Reactive Oxygen Species ◽  
Human Skin ◽  
Reactive Oxygen ◽  
Skin Fibroblasts ◽  
Oxygen Species ◽  
Human Skin Fibroblasts ◽  
Dependent Growth

3,3′-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts

2009 ◽  
Vol 54 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Kaya Lutter ◽  
Silke De Spirt ◽  
Sebastian Kock ◽  
Klaus-Dietrich Kröncke ◽  
Hans-Dieter Martin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Human Skin ◽  
Reactive Oxygen ◽  
Skin Fibroblasts ◽  
Zinc Ions ◽  
Oxygen Species ◽  
Human Skin Fibroblasts

Ugonin K Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal Pathway in Human Skin Cancer Cells

2013 ◽  
Vol 690-693 ◽  
pp. 1422-1425
Author(s):  
Leong Perng Chan ◽  
Tzung Han Chou ◽  
Guey Horng Wang ◽  
Ya Ping Tseng ◽  
Pin Ju Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Human Skin ◽  
Antioxidant Activities ◽  
Reactive Oxygen ◽  
Hacat Cells ◽  
Oxygen Species

The incidence and mortality of skin cancer continue to rise because of the destruction of the ozonosphere in the earth. Skin cancer is divided into two groups by histological features – nonmelanoma skin cancers (NMSC) and melanoma. Cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of NMSC are almost 75% among human skin malignancy cancer. In the preliminary bioactivity screening, the compound isolated from Helminthostachys zeylanica were evaluated antioxidant activities and interacted individually with serial human cancer cells, results that antioxidant activities of ugonin K were evaluated by measuring DPPH free-radical scavenging activities, and reducing power. Determination the reactive oxygen species (ROS) content and reduced glutathione (GSH) formation in H2O2-treated HaCaT cells by ugonin K. The cytotoxicity results show that ugonin K expressed less toxic to human keratinocytes (HaCaT cells) and human skin fibroblasts (Hs68 cells) than BCC cells, suggesting that ugonin K may have potential to be developed effective drugs for skin cancer cells without damaging skin normal cells. After treatment with ugonin K in BCC cells, cell cycle arrested in S-G2/M phase with a markedly increased apoptotic sub-G1 peak, mitochondria membrane potential (MMP) reduced, the expression of p53, Caspase-8, Caspase-9 and Caspase-3 revealed a more significant increased than the untreated control. Expected ugonin K has potential for an effective and specific drug to cancer cell, can minimize the damage to normal cell and provide a better therapeutic method to skin carcinoma.

A Reactive Oxygen Species-Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis

2015 ◽  
Vol 67 (6) ◽  
pp. 1611-1622 ◽  
Author(s):  
Tatiana Spadoni ◽  
Silvia Svegliati Baroni ◽  
Donatella Amico ◽  
Lisa Albani ◽  
Gianluca Moroncini ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Systemic Sclerosis ◽  
Reactive Oxygen ◽  
Skin Fibroblasts ◽  
Oxygen Species ◽  
Nadph Oxidases
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