scholarly journals The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses

1989 ◽  
Vol 61 (2) ◽  
pp. 285-290 ◽  
Author(s):  
K. M. Cunningham ◽  
N. W. Read

1. Three studies were carried out in each of six normal volunteers to investigate how lipid, when given at different stages during the course of a meal, affects gastric emptying and postprandial blood glucose and insulin concentrations.2. The control meal consisted of 300 ml beef consommé (50 kJ, 12 kcal), followed 20 min later by 300 g mashed potato (908 kJ, 217 kcal). In the two test meals, 60 g margarine were incorporated into either the soup or the mashed potato.3. The addition of margarine to either component of the meal delayed gastric emptying of the mashed potato (P< 0.05), but the pattern varied according to the component to which the fat was added.4. Incorporation of fat into the soup increased the lag phase (P< 0.05) but did not influence the slope of emptying of the mashed potato, while incorporation of fat into the mashed potato reduced the slope of emptying of the mashed potato (P< 0.05) but did not influence the lag phase.5. Addition of fat to either component of the meal reduced postprandial blood glucose (P< 0.05) and insulin responses, but when the fat was incorporated in the soup, peak glucose and insulin responses were delayed as well (P< 0.05).6. The results show that the effect of fat on gastric emptying and absorption of nutrients depends on when, in relation to the other components of the meal, the fat is consumed.

1987 ◽  
Vol 72 (2) ◽  
pp. 209-216 ◽  
Author(s):  
I. McL. Welch ◽  
C. Bruce ◽  
S. E. Hill ◽  
N. W. Read

1. Infusion of lipid into the ileum delays the transit of a meal through the stomach and small intestine and could therefore influence the rate and degree of nutrient absorption. 2. Experiments were carried out on human volunteers to investigate the effect of infusion of lipid into either the duodenum or ileum on blood glucose, insulin and gastric emptying after ingestion of a mashed potato meal. 3. Infusions of lipid into either the duodenum or the ileum significantly reduced or abolished the immediate postprandial rises in blood glucose and insulin and significantly delayed gastric emptying. Blood glucose and insulin rose shortly after the lipid infusion terminated. 4. Addition of corn oil to a meal of mashed potato also reduced blood glucose and insulin and delayed gastric emptying. 5. Intestinal lipid can thus modify the glycaemic and insulinaemic responses to a meal, and this modulation probably explains the reduced metabolic responses to a meal containing fat compared with a fat free meal. This principle could be of value in the dietary control of diabetes mellitus.


2009 ◽  
Vol 8 (1) ◽  
Author(s):  
Joanna Hlebowicz ◽  
Jenny Maria Jönsson ◽  
Sandra Lindstedt ◽  
Ola Björgell ◽  
Gassan Darwich ◽  
...  

2020 ◽  
Vol 88 ◽  
pp. 102963
Author(s):  
Tayler L. Hansen ◽  
Ellen M. Rankins ◽  
Jill M. Bobel ◽  
Meagan McKinney ◽  
Timothy J. Hackmann ◽  
...  

1986 ◽  
Vol 55 (1) ◽  
pp. 43-47 ◽  
Author(s):  
N. W. Read ◽  
I. McL. Welch ◽  
C. J. Austen ◽  
C. Barnish ◽  
C. E. Bartlett ◽  
...  

1. The degree to which disruption by mastication affects the glycaemic response to four different carbohydrate foods was investigated in healthy human volunteers; each food was eaten by six subjects.2. Subjects ate meals of sweetcorn, white rice, diced apple or potato on two occasions; on one occasion they chewed the food thoroughly, on the other occasion they swallowed each mouthful without chewing it.3. When the foods were chewed the postprandial blood glucose levels rose to levels which vaned according to the food ingested.4. Swallowing without chewing reduced the glycaemic response to each food, achieving a similar effect as administration of viscous polysaccharides or ‘slow-release’ carbohydrates.


PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 681-682
Author(s):  
William M. Liebman

I concur with Christensen that an insufficient rise in blood glucose after the oral lactose load may not be absolute for diagnosis of lactose intolerance, instead representing other factors, such as delayed gastric emptying. I further concur that some children may develop a stomachache associated with the examination procedure itself and not the lactose consumption. However, the number in my experience has been small. Furthermore, all children in my study with abnormal tests and/or symptomatology underwent a four-week trial of a lactosefree diet in order to further substantiate a causative role for lactose intolerance.


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