REDUCED POSTPRANDIAL BLOOD GLUCOSE LEVELS IN RECENTLY DIAGNOSED NON-INSULIN DEPENDENT DIABETICS SECONDARY TO PHARMACOLOGICALLY INDUCED DELAYED GASTRIC EMPTYING

1992 ◽  
Vol 17 (3) ◽  
pp. 254
Author(s):  
W. T. Phillips ◽  
J. G. Schwartz ◽  
C. A. McMahan ◽  
R. Blumhardt
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Delayed Gastric Emptying ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Insulin Dependent

scholarly journals The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses

1989 ◽  
Vol 61 (2) ◽  
pp. 285-290 ◽  
Author(s):  
K. M. Cunningham ◽  
N. W. Read
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Delayed Gastric Emptying ◽  
The Other ◽  
Postprandial Blood Glucose ◽  
Lag Phase ◽  
Normal Volunteers ◽  
Insulin Responses

1. Three studies were carried out in each of six normal volunteers to investigate how lipid, when given at different stages during the course of a meal, affects gastric emptying and postprandial blood glucose and insulin concentrations.2. The control meal consisted of 300 ml beef consommé (50 kJ, 12 kcal), followed 20 min later by 300 g mashed potato (908 kJ, 217 kcal). In the two test meals, 60 g margarine were incorporated into either the soup or the mashed potato.3. The addition of margarine to either component of the meal delayed gastric emptying of the mashed potato (P< 0.05), but the pattern varied according to the component to which the fat was added.4. Incorporation of fat into the soup increased the lag phase (P< 0.05) but did not influence the slope of emptying of the mashed potato, while incorporation of fat into the mashed potato reduced the slope of emptying of the mashed potato (P< 0.05) but did not influence the lag phase.5. Addition of fat to either component of the meal reduced postprandial blood glucose (P< 0.05) and insulin responses, but when the fat was incorporated in the soup, peak glucose and insulin responses were delayed as well (P< 0.05).6. The results show that the effect of fat on gastric emptying and absorption of nutrients depends on when, in relation to the other components of the meal, the fat is consumed.

scholarly journals Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

2016 ◽  
Vol 52 (4) ◽  
pp. 761-769 ◽  
Author(s):  
Any de Castro Ruiz Marques ◽  
Fabiana Percinoto Monteiro Schiavon ◽  
Patricia Batista Travassos ◽  
Vanessa Fontana Eik ◽  
Guilherme Godoy ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Clinical Models ◽  
The Impact

scholarly journals Effects of Various Blending Ratios of Rice and Waxy Barley on Postprandial Blood Glucose Levels

2018 ◽  
Vol 71 (6) ◽  
pp. 283-288
Author(s):  
Seiichiro Aoe ◽  
Kozo Komae ◽  
Yutaka Inoue ◽  
Isamu Murata ◽  
Yuki Minegishi ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals EFFECT OF AEROBIC EXERCISES AND RESISTANCE TRAINING ON GLUCOSE LEVELS IN TYPE 2 DIABETIC SUBJECTS.

2017 ◽  
Vol 10 (7) ◽  
pp. 360
Author(s):  
Aishwarya Pramod Benkar ◽  
Smita Bhimrao Kanase
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Resistance Training ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Objective: Diabetes mellitus is a leading cause of death and disability in the world and its prevalence is predicted to rise to 10% by 2030. Hence, this study is conducted with objectives to find out the effect of aerobic exercises and resisted exercises on blood glucose levels in type 2 diabetes mellitus (T2DM) subjects and to compare the effect of both exercises on blood glucose level.Method: The comparative study was conducted at Krishna Institute of Medical Sciences Deemed University, Physiotherapy department, Karad. 30 participants with age group between 30 and 65 years were taken. Subjects were selected as per inclusion and exclusion criteria. Group A (15) participants were given aerobic exercise on static bicycle, and Group B (15) participants were given resistance training using dumbbells and weight cuffs for 5 days/week for 4 weeks. Diet recommendations were given to every participant.Results: Statistical analysis was performed using paired and unpaired t-test. Analysis showed statistically extremely significant difference in fasting blood glucose level and postprandial blood glucose level in both the groups (p≤0.0001).Conclusion: Thus, this study concludes that both aerobic exercises and resistance training prove to be beneficial in controlling blood glucose levels in T2DM subjects.

scholarly journals Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats

2019 ◽  
Vol 7 (1) ◽  
pp. e000717 ◽  
Author(s):  
Minchun Zhang ◽  
Rilu Feng ◽  
Mei Yang ◽  
Cheng Qian ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
16S Rrna Gene Sequencing ◽  
Postprandial Blood Glucose ◽  
Saline Control ◽  
Rrna Gene ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Zucker Diabetic Fatty Rats

ObjectiveRecent studies have demonstrated that gut microbiota was closely related to metabolic disorders such as type 2 diabetes. Oral antidiabetic medications including metformin, acarbose and sitagliptin lowered blood glucose levels via acting on the gastrointestinal tract. The aim of the study was to observe the comparisons among those medications on gut microbiota composition.Research design and methodsZucker diabetic fatty rats (n=32) were randomly divided into four groups, and had respectively gastric administration of normal saline (control), metformin (215.15 mg/kg/day), acarbose (32.27 mg/kg/day), or sitagliptin (10.76 mg/kg/day) for 4 weeks. Blood glucose levels were measured during an intragastric starch tolerance test after the treatments. 16S rRNA gene sequencing was used to access the microbiota in the fecal samples.ResultsMetformin, acarbose, and sitagliptin monotherapy effectively decreased fasting and postprandial blood glucose levels (p<0.001). Acarbose group displayed specific cluster and enterotype mainly composed byRuminococcus 2whileLactobacilluswas the dominant bacterium in the enterotype of the other three groups. The relative abundance of generaRuminococcus 2andBifidobacteriumwas dramatically higher in acarbose group. Metformin and sitagliptin increased the relative abundance of genus Lactobacillus. Metagenomic prediction showed that the functional profiles of carbohydrate metabolism were enriched in acarbose group.ConclusionsMetformin, acarbose and sitagliptin exerted different effects on the composition of gut microbiota and selectively increased the beneficial bacteria. Supplementation with specific probiotics may further improve the hypoglycemic effects of the antidiabetic drugs.

Effective control of glycemic status and toxicity in Zucker diabetic fatty rats with an orally administered vanadate compound

2004 ◽  
Vol 82 (10) ◽  
pp. 888-894 ◽  
Author(s):  
Tod A Clark ◽  
Andrea L Edel ◽  
Clayton E Heyliger ◽  
Grant N Pierce
Keyword(s):  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Black Tea ◽  
Diabetic Rats ◽  
Type Ii ◽  
Sodium Orthovanadate ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Zucker Diabetic Fatty Rats ◽  
Insulin Dependent

A novel black tea decoction containing vanadate has successfully replaced insulin in a rat model of insulin-dependent diabetes but is untested in non-insulin-dependent diabetic animals. A tea-vanadate decoction (TV) containing 30 or 40 mg sodium orthovanadate was administered by oral gavage to two groups of Zucker diabetic fatty rats and a conventional water vehicle containing 30 or 40 mg of sodium orthovanadate to two others. In the latter group receiving the 30-mg dose, vanadate induced diarrhea in 50% of the rats and death in 10%. In contrast, TV-treated rats had no incidence of diarrhea and no deaths. Symptoms were more severe in both groups with higher vanadate doses, so these were discontinued. After ~16 weeks, the level of vanadium in plasma and tissue extracts was negligible in a further group of untreated rats but highly elevated after vanadate treatment. Vanadium levels were not significantly different between the TV-treated diabetic rats and the diabetic rats given vanadate in a water vehicle. Over the 115 days of the study, blood glucose levels increased from ~17 to 25 mmol/L in untreated diabetic rats. This was effectively lowered (to <10 mmol/L) by TV treatment. Fasting blood glucose levels were 5, 7, and 20 mmol/L in control (nondiabetic, untreated), TV-treated and untreated diabetic rats, respectively. Rats required treatment with TV for only ~50% of the days in the study. Increase in body mass during the study was significantly lower in untreated diabetic rats (despite higher food intake) than the other groups. Body mass gain and food intake were normal in TV-treated rats. Water intake was 28 mL/rat daily in control rats, 130 mL/rat daily in untreated diabetic rats, and 52 mL/rat daily in TV-treated diabetic rats. Plasma creatinine and aspartate aminotransferase levels were significantly depressed in untreated diabetic rats, and TV treatment normalized this. Our results demonstrate that a novel oral therapy containing black tea and vanadate possesses a striking capacity to regulate glucose and attenuates complications in a rat model of type II diabetes. Key words: diabetes mellitus, tea, glycemia, type II diabetes.

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