Incidence of Invasive Versus Non-invasive Carcinoma in Comparing Palpable and Non-palpable Solid Breast Lesions

Aims. DOG1 has proven to be a useful marker of gastrointestinal stromal tumors (GISTs). Recently, DOG1 expression has also been reported in some non-GIST malignant tumors, but the details related to DOG1 expression in breast tissue remain unclear. The aim of this study was to detect the expression of DOG1 in the human breast and to evaluate the feasibility of using DOG1 to discriminate between invasive breast carcinoma and noninvasive breast lesions.Methods and Results. A total of 210 cases, including both invasive and noninvasive breast lesions, were collected to assess DOG1 expression immunohistochemically. DOG1 expression was consistently positive in breast myoepithelial cells (MECs), which was similar to the results obtained for three other MEC markers: calponin, smooth muscle myosin heavy chain (SMMHC), and P63 (P>0.05in all). Importantly, DOG1 was useful in discriminating invasive breast carcinoma from noninvasive breast lesions (P<0.05).Conclusions. DOG1 is a useful marker of breast MECs, and adding DOG1 to the MEC identification panel will provide more sophisticated information when diagnosing uncertain cases in the breast.

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let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis

Lung Cancer ◽

10.1016/j.lungcan.2007.07.013 ◽

2007 ◽

Vol 58 (3) ◽

pp. 392-396 ◽

Cited By ~ 55

Author(s):

Kentaro Inamura ◽

Yuki Togashi ◽

Kimie Nomura ◽

Hironori Ninomiya ◽

Miyako Hiramatsu ◽

...

Keyword(s):

Invasive Carcinoma ◽

Microrna Expression ◽

Bronchioloalveolar Carcinoma ◽

Non Invasive

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Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia

Journal of Cellular and Molecular Medicine ◽

10.1111/j.1582-4934.2009.00868.x ◽

2009 ◽

Vol 14 (6b) ◽

pp. 1569-1593 ◽

Cited By ~ 45

Author(s):

Minna Takkunen ◽

Mika Hukkanen ◽

Mikko Liljeström ◽

Reidar Grenman ◽

Ismo Virtanen

Keyword(s):

Invasive Carcinoma ◽

Epithelial Mesenchymal Transition ◽

Carcinoma Cells ◽

Mesenchymal Transition ◽

Non Invasive

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Therapeutic mammotome excisions: radial scars

Breast Cancer Online ◽

10.1017/s1470903108004975 ◽

2008 ◽

Vol 11 (3) ◽

Author(s):

J. Morel ◽

M. J. Michell

Keyword(s):

Core Biopsy ◽

Invasive Carcinoma ◽

Surgical Excision ◽

Tissue Sampling ◽

Non Invasive ◽

Associated Lesions ◽

Risk Of Malignancy ◽

Associated Malignancy

AbstractBenign radial scars, lesions characterised histologically by a fibroelastic core surrounded by stellate duct proliferation, cannot be differentiated from lesions with associated invasive or non-invasive carcinoma on imaging, and histological sampling is therefore mandatory. There is also extensive evidence of the frequency with which radial scars are associated with malignancy and with other lesions that have an associated risk of malignancy. The traditionally accepted management has been the surgical excision of all suspected radial scars because insufficient tissue was removed by standard biopsy techniques to exclude associated lesions. In more recent series, it has been shown that with extensive tissue sampling of such lesions with core biopsy and modern vacuum-assisted sampling devices, the presence of associated malignancy can be excluded, thus negating the need for surgical excision.

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