Presence of activated T lymphocytes in peripheral blood of head and neck squamous cell carcinoma patients predicts impaired prognosis

2006 ◽  
Vol 126 (12) ◽  
pp. 1326-1333 ◽  
Author(s):  
Hans Jørgen Aarstad ◽  
John-Helge Heimdal ◽  
Beate Klementsen ◽  
Jan Olofsson ◽  
Elling Ulvestad
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Peripheral Blood ◽  
Neck Squamous Cell Carcinoma ◽  
Activated T Lymphocytes

scholarly journals Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
S. S. Jeske ◽  
P. J. Schuler ◽  
J. Doescher ◽  
M. N. Theodoraki ◽  
S. Laban ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Age Related ◽  
Age Related Changes

Polyfunctionality of CD4+ T lymphocytes is increased after chemoradiotherapy of head and neck squamous cell carcinoma

2018 ◽  
Vol 194 (5) ◽  
pp. 392-402 ◽  
Author(s):  
J. Doescher ◽  
S. Jeske ◽  
S. E. Weissinger ◽  
C. Brunner ◽  
S. Laban ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals Predictive and prognostic significance of telomerase levels/telomere length in tissues and peripheral blood in head and neck squamous cell carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paolo Boscolo-Rizzo ◽  
Enrica Rampazzo ◽  
Jerry Polesel ◽  
Silvia Giunco ◽  
Anna Menegaldo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Telomere Length ◽  
Squamous Cell ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Prognostic Significance ◽  
Response To Therapy ◽  
Neck Squamous Cell Carcinoma

AbstractA growing body of evidence indicates that the expression of TERT, the catalytic subunit of telomerase, is a biological marker of progression in several cancers. We investigated the predictive and prognostic role of TERT levels and telomere length in tissues and peripheral blood in patients with head and neck squamous cell carcinoma (HNSCC). High TERT levels in cancer tissues were independently associated with worse response to therapy (odds ratio [OR]:6.26), regional failure (hazard ratio [HR]:5.75), progression (HR:2.12), and death (HR:3.53). Longer telomeres in the mucosa surrounding the tumor (SM) were independently associated with a lower risk of mucosal failure (HR:0.39). While telomere length in peripheral blood mononuclear cells (PBMC) significantly decreased with age, no correlation was found between age and telomere length in SM. No associations were found between TERT levels in plasma and telomere length in PBMC and the prognostic variables. High levels of TERT transcripts in cancer cells represent a reliable prognostic marker for identifying HNSCC patients with risk of progression. The altered relationship of telomere length to age in SM compared with PBMC suggests that in a subset of cases the phenotypically normal SM constitutes an acquired telomere-shortened epithelial field prone to genetic instability.

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