This paper presents the results of an investigation of active control of combustion instabilities in a natural gas, high-pressure, full-scale gas turbine combustor that was retrofitted with an Active Control System (ACS). The combustor test rig simulates the geometry, inlet airflow distribution, and pressurization of a can-type combustor that exhibits dynamic flame instabilities at some off-design operating conditions. Two essential features of the investigated ACS are 1) a real-time mode observer that identified the frequencies, amplitudes and phases of the dominant modes in the pressure signal and 2) a fast response servo valve that can modulate a large portion of the gaseous fuel. Two active control configurations were studied. In the first configuration, the actuator was mounted on one of two premixed fuel stages, and in the second configuration it was mounted on the inlet to the stabilizing diffusion stage. In both configurations, the ACS damped combustion instabilities, attenuating the dominant mode by up to 15dB and reducing the overall broadband noise by 30-40%. NOx emissions were also reduced by approximately 10% when control was applied. Finally, this study demonstrated the importance of having a fast multiple-mode observer when dealing with complex combustion processes with inherently large time delays.