A 25 Gbps VCSEL driving ASIC: an attempt for ultra-high-speed front-end readout applications

This paper presents the design and the test results of a 25 Gbps VCSEL driving ASIC fabricated in a 55 nm CMOS technology as an attempt for the future very high-speed optical links. The VCSEL driving ASIC is composed of an input equalizer stage, a pre-driver stage and a novel output driver stage. To achieve high bandwidth, the pre-driver stage combines the inductor-shared peaking structure and the active-feedback technique. A novel output driver stage uses the pseudo differential CML driver structure and the adjustable FFE pre-emphasis technique to improve the bandwidth. This VCSEL driver has been integrated in a customized optical module with a VCSEL array. Both the electrical function and optical performance have been fully evaluated. The output optical eye diagram has passed the eye mask test at the data rate of 25 Gbps. The peak-to-peak jitter of 25 Gbps optical eye is 19.5 ps and the RMS jitter is 2.9 ps.

Capturing the start point of the virus-cell interaction with high-speed 3D single-virus tracking

The early stages of the virus-cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in the extracellular space and the large 3D cellular structures involved. Here we present an active-feedback single-virus tracking method with simultaneous volumetric imaging of the live cell environment to address this knowledge gap to present unprecedented detail to the extracellular phase of the infectious cycle. We report previously unobserved phenomena in the early stages of the virus-cell interaction, including skimming contact events at the millisecond timescale, orders of magnitude change in diffusion coefficient upon binding, and cylindrical and linear diffusion modes along filopodia. Finally, we demonstrate how this new method can move single-virus tracking from simple monolayer culture towards more tissue-like conditions by tracking single virions in tightly packed epithelial cells. This multi-resolution method presents new opportunities for capturing fast, 3D processes in biological systems.

A 1.8 to 4 GHz inductor-less highly linear CMOS LNA for wire-less receivers

This paper presents an inductor-less wide-band highly linear low-noise amplifier (LNA) for wire-less receivers. The inductor-less LNA consists of a complementary current-reuse common source amplifier combined with a low-current active feedback to obtain wide range input impedance matching and low noise figure. In our LNA, a degeneration resistor is utilized to improve linearity of the LNA. Furthermore, we designed a bypass mode for the LNA to extend the range of its applications. The proposed LNA is implemented in 28 nm CMOS process. It has a gain of 14.9 dB and a bandwidth of 2.2 GHz. The noise figure (NF) is 1.95 dB and the third-order input intercept point (IIP3) is 24.8 dBm at 2.3 GHz. It consumes 17.2 mW at a 0.9-V supply and has an area of 0.011 mm2.

Unique technologies for organizing medical care for COVID-19 patients with concomitant diseases of the cardiovascular system and surgical pathology

The article describes some of the key elements of unique technologies for organizing medical care for patients with COVID-19 with concomitant diseases of the cardiovascular system and surgical pathology, which, along with ensuring infectious safety, allow to optimize the stream of value creation for these patients. Innovative approaches to managing the production activities of a medical organization are proposed. The goal of the work done by the hospital administration was to create a management model for a state medical organization based on modern methods, including a process-oriented approach and lean healthcare technologies. The relevance of the chosen topic is due to the fact that the activities of healthcare institutions in the context of the global coronavirus pandemic require more flexibility and mobility; therefore, the primary task is to master new management tools for a medical organization, taking into account industry characteristics and consumer needs. Analytical and descriptive methods, sociological survey were used. The article describes our own experience in carrying out structural changes in a medical organization. The use of modern management approaches allows the formation of positive interaction within the workforce and provides active feedback with patients.

In-Situ Depth Measurement of Laser Micromachining

Precision laser micromachining plays an important role in the biomedical, electronics, and material processing industries. During laser drilling, precision depth detection with micrometer-level resolution is required, particularly with blind-hole or heterogeneous structures. We present an optical detection system utilizing an optical confocal structure, experimentally confirmed to achieve a >95% accuracy for micron-diameter holes that are tens-of-microns deep. This system can be easily integrated into commercial laser micromachining processes, and can be employed in laser drilling and three-dimensional active-feedback laser printing.

Motion and Sash Height (MASH) alarms for efficient fume hood use

Ventilation, including fume hoods, consumes 40–70% of the total energy used by modern laboratories. Energy-conscious fume hood usage—for example, closing the sash when a hood is unused—can significantly reduce energy expenditures due to ventilation. Prior approaches to promote such behaviors among lab users have primarily relied on passive feedback methods. In this work, we developed a low-cost fume hood monitoring device with active feedback to alert lab users when a fume hood is left open and unused. Using data collected by the building management system, we observed a 75.6% decrease in the average sash height after installation of these “Motion and Sash Height” (MASH) alarms, which would result in a reduction roughly equal to 43% of the annual carbon emissions of a typical American vehicle, for each fume hood. The MASH alarm presented here reduced energy costs by approximately $1,159 per year, per hood, at MIT.

Beam and sample movement compensation for robust spectro-microscopy measurements on a hard X-ray nanoprobe

Static and in situ nanoscale spectro-microscopy is now routinely performed on the Hard X-ray Nanoprobe beamline at Diamond and the solutions implemented to provide robust energy scanning and experimental operation are described. A software-based scheme for active feedback stabilization of X-ray beam position and monochromatic beam flux across the operating energy range of the beamline is reported, consisting of two linked feedback loops using extremum seeking and position control. Multimodal registration methods have been implemented for active compensation of drift during an experiment to compensate for sample movement during in situ experiments or from beam-induced effects.