A novel approach to lean control for Taiwan-funded enterprises in mainland China

Abstract. The evaluation of the seismic fragility of buildings is one key task of earthquake safety and loss assessment. Many research reports and papers have been published over the past 4 decades that deal with the vulnerability of buildings to ground motion caused by earthquakes in China. We first scrutinized 69 papers and theses studying building damage for earthquakes that occurred in densely populated areas. They represent observations where macroseismic intensities have been determined according to the official Chinese Seismic Intensity Scale. From these many studies we derived the median fragility functions (dependent on intensity) for four damage limit states of the two most widely distributed building types: masonry and reinforced concrete. We also inspected 18 publications that provide analytical fragility functions (dependent on PGA, peak ground acceleration) for the same damage classes and building categories. Thus, a solid fragility database based on both intensity and PGA is established for seismicity-prone areas in mainland China. A comprehensive view of the problems posed by the evaluation of fragility for different building types is given. Based on the newly collected fragility database, we propose a new approach in deriving intensity–PGA relations by using fragility as the bridge, and reasonable intensity–PGA relations are developed. This novel approach may shed light on new thought in decreasing the scatter in traditional intensity–PGA relation development, i.e., by further classifying observed macroseismic intensities and instrumental ground motions based on differences in building seismic resistance capability.

Download Full-text

Review of fragility analyses for major building types in China with new implications for intensity-PGA relation development

10.5194/nhess-2019-195 ◽

2019 ◽

Cited By ~ 1

Author(s):

Danhua Xin ◽

James Edward Daniell ◽

Friedemann Wenzel

Keyword(s):

Mainland China ◽

Seismic Intensity ◽

Fragility Functions ◽

Loss Assessment ◽

Limit States ◽

New Thought ◽

Novel Approach ◽

Earthquakes In China ◽

International Projects ◽

Relation Development

Abstract. The evaluation of the seismic fragility of buildings is one key task of earthquake safety and loss assessment. Many research reports and papers have been published over the past four decades that deal with the vulnerability of buildings to ground motion caused by earthquakes in China. We first scrutinized 69 papers and theses studying building damage for earthquakes occurred in densely populated areas. They represent observations where macro-seismic intensities have been determined according to the Chinese Official Seismic Intensity Scale. From these many studies we derived the median fragility functions (dependent on intensity) for four damage limit states of two most widely distributed building types: masonry and reinforced concrete. We also inspected 18 publications that provide analytical fragility functions (dependent on PGA) for the same damage classes and building categories. Thus, a solid fragility database based on both intensity and PGA is established for seismic prone areas in mainland China. A comprehensive view of the problems posed by the evaluation of fragility for different building types is given. Necessary comparison with international projects with similar focus is conducted. Based on the newly collected fragility database, we propose a new approach in deriving intensity-PGA relation by using fragility as the bridge and reasonable intensity-PGA relations are developed. This novel approach may shed light on new thought in decreasing the scatter in traditional intensity-PGA relation development, i.e., by further classifying observed macro-seismic intensities and instrumental ground motions based on difference in building seismic resistance capability.

Download Full-text

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Download Full-text

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

Language Speech and Hearing Services in Schools ◽

10.1044/2020_lshss-19-00050 ◽

2020 ◽

Vol 51 (3) ◽

pp. 544-560 ◽

Cited By ~ 3

Author(s):

Kimberly A. Murphy ◽

Emily A. Diehm

Keyword(s):

Written Language ◽

Morphological Knowledge ◽

English Orthography ◽

Word Level ◽

Novel Approach ◽

Language Pathology ◽

The One ◽

Critical Intervention ◽

Reading And Spelling ◽

Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Download Full-text