A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries

2004 ◽  
Vol 64 (4) ◽  
pp. 385-398 ◽  
Author(s):  
G. Nordin ◽  
A. Mårtensson ◽  
B. Swolin ◽  
S. Sandberg ◽  
N. J. Christensen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Multicentre Study ◽  
Adult Population ◽  
Reference Intervals ◽  
Nordic Countries ◽  
Erythrocyte Indices ◽  
Cell Counts ◽  
Blood Cell Counts

scholarly journals Changes in Serum Lipids from Egg Consumption Are Associated with Clinical Erythrocyte Indices (P08-093-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Julia Greco ◽  
Allison Sloan ◽  
Christa Palancia Esposito ◽  
Aaron Van Dyke ◽  
Catherine Andersen
Keyword(s):  
Blood Cell ◽  
Total Cholesterol ◽  
Red Blood Cell ◽  
Serum Lipids ◽  
Hdl Cholesterol ◽  
Distribution Width ◽  
Erythrocyte Indices ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Induced Changes

Abstract Objectives Serum lipids may influence the lifespan of erythrocytes, and have been associated with clinical erythrocyte indices at the population level. Consumption of whole eggs vs. egg whites exerts varying effects on serum lipids and lipoprotein profiles; therefore, we investigated whether egg-induced changes in serum lipids correspond to changes in clinical erythrocyte markers. Methods Young, healthy men and women (18–35y, BMI < 30 kg/m2, n = 11) were recruited to participate in an ongoing intervention trial. All subjects followed an egg-free diet for 4 weeks, then were randomized to consume either 3 whole eggs or 3 egg whites per day for 4 weeks. Fasting serum lipids, complete blood cell counts, and dietary intake analysis was performed at the end of each study period. Results Average serum lipids and erythrocyte indices were within normal ranges at the end of each diet period. Changes in total cholesterol following the whole egg (+4.8%) and egg white (0.4%) diet period were not significant as compared to the egg-free diet period. Similarly, clinical erythrocyte markers were not significantly altered by daily consumption of whole eggs or egg whites. However, changes in total cholesterol and LDL-cholesterol between diet periods were positively correlated with changes in total red blood cell counts and hemoglobin. Total cholesterol was additionally correlated with hematocrit levels, and negatively associated with red cell distribution width. Total red blood cell counts and hemoglobin were further correlated with changes in the total cholesterol to HDL-cholesterol ratios, but not HDL-cholesterol alone. Conclusions Our findings indicate that egg-induced changes in serum lipids are associated with clinical erythrocyte indices, and that total cholesterol levels and dyslipidemia may be more significant determinants of erythrocyte profiles. Funding Sources This study was funded by an Agriculture and Food Research Initiative Grant from the USDA National Institute of Food and Agriculture.

scholarly journals Hematological, Hormonal and Fitness Indices in Youth Swimmers: Gender‐Related Comparisons

2019 ◽  
Vol 70 (1) ◽  
pp. 69-80
Author(s):  
Guang Cai ◽  
Jun Qiu ◽  
Shuai Chen ◽  
Qile Pan ◽  
Xunzhang Shen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Anaerobic Power ◽  
Anaerobic Capacity ◽  
Hemoglobin Concentration ◽  
Erythrocyte Indices ◽  
Testosterone Levels ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Aerobic And Anaerobic

Abstract This study objective was to evaluate gender differences in hematological, hormonal and fitness variables among youth swimmers and to explore relationships between erythrocyte indices and aerobic and anaerobic capacity. 137 girls and 171 boys participated in the study and were divided into three groups based on their training experience. Blood samples were obtained to determine red blood cell counts, hemoglobin concentration, hematocrit, and plasma erythropoietin and testosterone levels. VO2max was assessed using a submaximal cycle protocol. 76 girls and 102 boys also undertook a Wingate test to determine their peak anaerobic power. Boys had higher (p < 0.05) means than girls for all hematological variables except for erythropoietin and these variables demonstrated an increase with training in boys. The average VO2max in l∙min-1 and peak anaerobic power in watts were also higher in boys (2.91 ± 0.08 and 547 ± 28, respectively) than girls (2.25 ± 0.07 and 450 ± 26, respectively). Modest but significant (p < 0.05) correlations were found between VO2max and red blood cell counts (r = 0.252), hemoglobin concentration (r = 0.345), or hematocrit (r = 0.345) and between peak anaerobic power and red blood cell counts (r = 0.304), hemoglobin concentration (r = 0.319) or hematocrit (r = 0.351). This study revealed relatively lower yet age- and gender-appropriate hematological, hormonal and fitness indices in youth swimmers. The gender-related differences in erythrocyte indices seem unrelated to erythropoietin and may be explained by the higher testosterone levels seen in boys. Given their correlation to both aerobic and anaerobic capacity, erythrocyte indices may be used as part of talent identification for sports.

scholarly journals PO-116 Hematological, hormonal and fitness indices in youth swimmers: gender-related comparisons

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Jun Qiu ◽  
Guang Cai ◽  
Shuai Chen ◽  
Qile Pan ◽  
Xunzhang Shen ◽  
...  
Keyword(s):  
Gender Differences ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Anaerobic Power ◽  
Hemoglobin Concentration ◽  
Erythrocyte Indices ◽  
Testosterone Levels ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Aerobic And Anaerobic

Objective This study was to evaluate gender differences in hematological, hormonal and fitness parameters among youth swimmers and to explore relationships between erythrocyte indices and aerobic and anaerobic capacity.  Methods 308 youth swimmers including 137 girls and 171 boys aged 8 to 16 volunteered to participate in this study, and they were divided into three (Beginner, intermediate and advanced) groups based on their training experiences. Blood samples were obtained to determine red blood cell counts, hemoglobin concentration, hematocrit, and serum erythropoietin and testosterone levels. VO2max was assessed using a submaximal cycle protocol. 76 girls and 102 boys also undertook a Wingate test to determine their peak anaerobic power. One-way analysis of variance (ANOVA) was used to compare gender differences in hematological indices hormonal indices and aerobic and anaerobic capacities. Two-way (gender × training) ANOVA was used to analyze the interactive effect of gender and training on hematological variables. Results Boys had higher (p<0.05) means than girls for all hematological variables except for erythropoietin and values demonstrated an increase with training in boys. The average VO2max in l∙min-1 and peak anaerobic power in watts were also higher in boys (2.91±0.08 and 547±28, respectively) than girls (2.25±0,07 and 450±26, respectively). Modest but significant (p<0.05) correlations were found between VO2max and red blood cell counts (r=0.252), hemoglobin concentration (r=0.345), or hematocrit (r=0.345) and between peak anaerobic power and red blood cell counts (r=0.304), hemoglobin concentration (r=0.319) or hematocrit (r=0.351).  Conclusions This study revealed relatively lower yet age- and gender-appropriate hematological, hormonal and fitness indices in youth swimmers. The gender-related differences in erythrocyte indices seems unrelated to erythropoietin and may be explained by the higher testosterone levels seen in boys. Erythrocyte indices may be used as part of talent identification for sports. 

Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Ingo Mrosewski ◽  
Tobias Dähn ◽  
Jörg Hehde ◽  
Elena Kalinowski ◽  
Ilona Lindner ◽  
...  
Keyword(s):  
Data Mining ◽  
Blood Cell ◽  
Pediatric Patients ◽  
Clinical Laboratory ◽  
Clinical Chemistry ◽  
Pediatric Population ◽  
Reference Intervals ◽  
Multicenter Studies ◽  
Cell Counts ◽  
Blood Cell Counts

Abstract Objectives Establishing direct reference intervals (RIs) for pediatric patients is a very challenging endeavor. Indirectly determined RIs can address this problem by utilization of existing clinical laboratory databases. In order to provide better laboratory services to the local pediatric population, we established population-specific hematology RIs via data mining. Methods Our laboratory information system (LIS) was searched for pediatric blood counts of patients aged from 0 days to 18 years, performed from 1st of January 2018 until 31st of March 2021. In total, 27,554 blood counts on our SYSMEX XN-9000 were initially identified. After application of pre-defined exclusion criteria, 18,531 sample sets remained. Age- and sex-specific RIs were established in accordance with International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and Clinical & Laboratory Standards Institute (CLSI) recommendations. Results When compared to pediatric RIs supplied by other authors, the RIs determined specifically for pediatric patients from Berlin and Brandenburg showed several relevant differences, especially with regard to white blood cell counts (WBCs), red blood cell counts (RBCs), red cell distribution widths (RDW) and platelet counts (PLTs) within the distinct age groups. Additionally, alterations to several published age-specific partitions had to be made, while new sex-specific partitions were introduced for WBCs and PLTs. Conclusions Generic RIs from textbooks, manufacturer information and medical publications – even from nationwide or multicenter studies – commonly used in many laboratories might not reflect the specifics of local patient populations properly. RIs should be tailored to the serviced patient population whenever possible. Careful data mining appears to be suitable for this task.

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

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