Skeletal deformities associated with nutritional congenital rickets in newborn lambs

2016 ◽  
Vol 65 (1) ◽  
pp. 51-55 ◽  
Author(s):  
KE Dittmer ◽  
RE Morley ◽  
RL Smith
Keyword(s):  
Skeletal Deformities ◽  
Congenital Rickets

Skeletal deformities in the larvae and juveniles of cultured tongue sole (Cynoglossus semilaevis)

2013 ◽  
Vol 18 (6) ◽  
pp. 1399-1405
Author(s):  
Hui MA ◽  
Zhimeng ZHUANG ◽  
Shufang LIU ◽  
Qian MA ◽  
Xiuli WANG
Keyword(s):  
Cynoglossus Semilaevis ◽  
Skeletal Deformities ◽  
Larvae And Juveniles ◽  
Tongue Sole

scholarly journals Skeletal Deformities in Osterix-Cre;Tgfbr2f/f Mice May Cause Postnatal Death

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 975
Author(s):  
Kara Corps ◽  
Monica Stanwick ◽  
Juliann Rectenwald ◽  
Andrew Kruggel ◽  
Sarah B. Peters
Keyword(s):  
Transforming Growth Factor ◽  
Skeletal Development ◽  
Transforming Growth Factor Β ◽  
Tgfβ Signaling ◽  
Skeletal Deformities ◽  
Tooth Abnormalities ◽  
Pathological Analysis ◽  
Diaphragmatic Muscle ◽  
Proliferation And Differentiation ◽  
Tgfβ Receptor

Transforming growth factor β (TGFβ) signaling plays an important role in skeletal development. We previously demonstrated that the loss of TGFβ receptor II (Tgfbr2) in Osterix-Cre-expressing mesenchyme results in defects in bones and teeth due to reduced proliferation and differentiation in pre-osteoblasts and pre-odontoblasts. These Osterix-Cre;Tgfbr2f/f mice typically die within approximately four weeks for unknown reasons. To investigate the cause of death, we performed extensive pathological analysis on Osterix-Cre- (Cre-), Osterix-Cre+;Tgfbr2f/wt (HET), and Osterix-Cre+;Tgfbr2f/f (CKO) mice. We also crossed Osterix-Cre mice with the ROSA26mTmG reporter line to identify potential off-target Cre expression. The findings recapitulated published skeletal and tooth abnormalities and revealed previously unreported osteochondral dysplasia throughout both the appendicular and axial skeletons in the CKO mice, including the calvaria. Alterations to the nasal area and teeth suggest a potentially reduced capacity to sense and process food, while off-target Cre expression in the gastrointestinal tract may indicate an inability to absorb nutrients. Additionally, altered nasal passages and unexplained changes in diaphragmatic muscle support the possibility of hypoxia. We conclude that these mice likely died due to a combination of breathing difficulties, malnutrition, and starvation resulting primarily from skeletal deformities that decreased their ability to sense, gather, and process food.

scholarly journals Congenital rickets caused by maternal vitamin D deficiency

2002 ◽  
Vol 7 (7) ◽  
pp. 455-458 ◽  
Author(s):  
A Micheil Innes ◽  
Molly M Seshia ◽  
Chitra Prasad ◽  
Saif Al Saif ◽  
Frank R Friesen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Maternal Vitamin ◽  
Congenital Rickets

scholarly journals Three-dimensional study of the orbit-related structures according to sex, age and skeletal deformities

2021 ◽  
Vol 10 (11) ◽  
pp. e77101119381
Author(s):  
Tamara Fernandes de Castro ◽  
Liogi Iwaki Filho ◽  
Amanda Lury Yamashita ◽  
Fernanda Chiguti Yamashita ◽  
Naiara Caroline Aparecido dos Santos ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Class I ◽  
Class Iii ◽  
Gamma Model ◽  
Orbital Reconstruction ◽  
Skeletal Deformities ◽  
Infraorbital Canal ◽  
Male Patients ◽  
Post Hoc ◽  
Supraorbital Foramen

Objective: This study aimed to evaluate the relations between orbit-related structures and sex, age and skeletal deformities using cone-beam computed tomography (CBCT). Methods: This retrospective study evaluated 216 consecutive CBCT scans of patients, who were divided according to: sex (male, n=105; female, n=111), age (A1: 18-32 years, n=71; A2: 33-47 years, n=78; A3: 48-62 years, n=67), and skeletal deformities (Class I, n=70; Class II, n=75; Class III, n=71). The supraorbital foramen (SOF) location, volume of orbit, optic canal (OC) and infraorbital canal (IOC) were evaluated. Results were analyzed using the Gamma model test. The Tukey-Kramer post-hoc test was used to compare the variables with three factors (p<0.05). Results: The IOC volume showed higher values for male, A3 and class I patients. The SOF location and the orbital volume also showed higher values for male patients. Regarding the volume of CO, it showed higher values ​​for male and class I patients. Conclusions: According to our results, sex has been shown to have a significant influence on orbit-related structures. Age and skeletal deformities also influenced the volume of IOC and OC. These results eventually help the clinical practice, being useful for orbital reconstruction surgeries, anthropological studies, gender identification and identification of susceptibility to pathological conditions related to sexual dimorphism.

scholarly journals Left-sided Gastroschisis with Skeletal Deformities

2018 ◽  
Author(s):  
Rajkumar Motiram Meshram ◽  
Amruta Phatak ◽  
Balaji Bhise ◽  
Avinash Chichkhede ◽  
Duhita Sengupta
Keyword(s):  
Skeletal Deformities
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