Comparison of the pharmacokinetics of verapamil in the pregnant and non-pregnant rabbit: study of maternal and foetal tissue levels

Xenobiotica ◽  
2000 ◽  
Vol 30 (1) ◽  
pp. 93-102 ◽  
Author(s):  
C. Solans, M. A. Bregante, J. J. Ar
Keyword(s):  
Tissue Levels ◽  
Foetal Tissue ◽  
Pregnant Rabbit

Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal tissue levels

Xenobiotica ◽  
2000 ◽  
Vol 30 (8) ◽  
pp. 831-841 ◽  
Author(s):  
M. A. Bregante ◽  
J. J. Aramayona ◽  
L. J. Fraile ◽  
M. A. Garcia ◽  
C. Solans
Keyword(s):  
Tissue Levels ◽  
Foetal Tissue ◽  
Pregnant Rabbit

PURIFICATION AND SOME PROPERTIES OF OVINE PLACENTAL LACTOGEN

1978 ◽  
Vol 78 (1) ◽  
pp. 59-69 ◽  
Author(s):  
S. REDDY ◽  
W. B. WATKINS
Keyword(s):  
Mammary Gland ◽  
Polyacrylamide Gel Electrophoresis ◽  
Ammonium Bicarbonate ◽  
Placental Lactogen ◽  
Supernatant Fraction ◽  
Major Band ◽  
Foetal Tissue ◽  
Pregnant Rabbit ◽  
Ovine Prolactin

A method has been described for the purification of ovine placental lactogen (oPL) involving the use of freshly obtained sheep foetal cotyledons. Tissue was extracted with 0·1 m-ammonium bicarbonate and the supernatant fraction, adjusted to pH 7, was brought to 60% saturation with ammonium sulphate. The resulting precipitate was then subjected to a sequence of chromatographic steps using columns of Sephadex G-100 and carboxymethylcellulose. During each stage of the purification, the lactogenic activity was monitored with a pregnant rabbit mammary gland radioreceptor assay. The yield of oPL corresponded to 8 mg/kg wet foetal tissue and the oPL possessed lactogenic activity equivalent to 1 mg ovine prolactin/mg protein and GH-like activity equivalent to 0·8 mg human GH/mg protein. The biological activity of oPL was confirmed using a rabbit intraductal mammary gland assay in vivo. After polyacrylamide gel electrophoresis at pH 8·9, oPL was resolved into one major band (isoelectric point 8·2–8·4) and four minor components, which were thought to be deamidation products of oPL. Microimmunoelectrophoresis and immunodiffusion studies confirmed that the preparation of oPL was free from serum protein contaminants.

Trace Element Contents in Thyroid Cancer Investigated by Instrumental Neutron Activation Analysis

2018 ◽  
Vol 1 (1) ◽  
pp. 1-13
Keyword(s):  
Thyroid Cancer ◽  
Neutron Activation Analysis ◽  
Instrumental Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Trace Element ◽  
Thyroid Tissue ◽  
Tissue Levels ◽  
Trace Element Contents ◽  
Element Contents

Background: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn exist in the malignantly transformed thyroid. Methods: Thyroid tissue levels of ten trace elements were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Results: It was found that contents of Ag, Co, Cr, Hg, and Rb were significantly higher (approximately 12.8, 1.4, 1.6, 19.6, and 1.7 times, respectively) in cancerous tissues than in normal tissues. Conclusions: There are considerable changes in trace element contents in the malignantly transformed tissue of thyroid.

scholarly journals The Colonic Tissue Levels of TLR2, TLR4 and Nitric Oxide in Patients with Irritable Bowel Syndrome

2016 ◽  
Vol 55 (9) ◽  
pp. 1043-1048 ◽  
Author(s):  
Erdem Koçak ◽  
Erdem Akbal ◽  
Seyfettin Köklü ◽  
Bilal Ergül ◽  
Murat Can
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Colonic Tissue ◽  
Tissue Levels ◽  
Irritable Bowel

Brain tissue levels in a fatal case of neonatal mepivacaine (Carbocaine) poisoning

1975 ◽  
Vol 86 (4) ◽  
pp. 624-627 ◽  
Author(s):  
W. Edwin Dodson ◽  
Richard E. Hillman ◽  
Laura S. Hillman
Keyword(s):  
Brain Tissue ◽  
Fatal Case ◽  
Tissue Levels
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