A Study of Cefamandole Prostatic Tissue Levels

1981 ◽  
Vol 53 (4) ◽  
pp. 336-338 ◽  
Author(s):  
A. V. KAISARY
Keyword(s):  
Prostatic Tissue ◽  
Tissue Levels

scholarly journals Prostatic Tissue Levels of 43 Trace Elements in Patients with Prostate Adenocarcinoma

2016 ◽  
Vol 5 (1) ◽  
pp. 79 ◽  
Author(s):  
Vladimir Zaichick ◽  
Sofia Zaichick
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Prostate Gland ◽  
Trace Element Analysis ◽  
Developed Countries ◽  
Prostate Adenocarcinoma ◽  
Prostatic Tissue ◽  
Element Analysis ◽  
Tissue Samples ◽  
Tissue Levels

Adenocarcinoma of prostate gland is an internationally important health problem in men, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the prostatic tissue levels of trace elements exist in the malignantly transformed prostate. Prostatic tissue levels of 43 trace elements were prospectively evaluated in 36 patients with prostate adenocarcinoma and 37 healthy males. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma mass spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. The reliability of difference in the results between normal and cancerous prostate tissues was evaluated by Student’s t-test. It was found that the contents of Ag, Al, Au, B, Be, Br, Ce, Cr, Dy, Er, Fe, Gd, Hg, Li, Mn, Nd, Ni, Pr, Sb, Sn, Th, Tl, Y, and Zr were significantly higher while those of Cd, Co, Rb, Sc, Se, and Zn were significantly lower in cancerous tissues than in normal tissues. Moreover, it was shown that malignant transformation significantly changed the relationships of trace elements in prostate. Thus, in adenocarcinoma transformed prostate tissue the trace element metabolism is significantly disturbed.

Prostatic tissue levels of ofloxacin

Urology ◽  
1991 ◽  
Vol 38 (4) ◽  
pp. 380-382 ◽  
Author(s):  
J. Aagaard ◽  
J. Knes ◽  
P.O. Madsen
Keyword(s):  
Prostatic Tissue ◽  
Tissue Levels

673: Utility of Resection of Additional Peri-Prostatic Tissue in Patients Undergoing Radical Prostatectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 217-217
Author(s):  
Ganesh V. Raj ◽  
Rahul Iyer ◽  
Fernando J. Bianco ◽  
Bertrand Guillonneau ◽  
Peter T. Scardino ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostatic Tissue

Trace Element Contents in Thyroid Cancer Investigated by Instrumental Neutron Activation Analysis

2018 ◽  
Vol 1 (1) ◽  
pp. 1-13
Keyword(s):  
Thyroid Cancer ◽  
Neutron Activation Analysis ◽  
Instrumental Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Trace Element ◽  
Thyroid Tissue ◽  
Tissue Levels ◽  
Trace Element Contents ◽  
Element Contents

Background: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn exist in the malignantly transformed thyroid. Methods: Thyroid tissue levels of ten trace elements were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Results: It was found that contents of Ag, Co, Cr, Hg, and Rb were significantly higher (approximately 12.8, 1.4, 1.6, 19.6, and 1.7 times, respectively) in cancerous tissues than in normal tissues. Conclusions: There are considerable changes in trace element contents in the malignantly transformed tissue of thyroid.

scholarly journals Ectopic prostatic tissue with eosinophilic epithelial metaplasia in anterior urethra: A case report

2021 ◽  
Vol 24 ◽  
pp. 200500
Author(s):  
Dorian Dikov ◽  
Maria Koleva ◽  
Elena Gerakova ◽  
Veselin Belovejdov
Keyword(s):  
Case Report ◽  
Prostatic Tissue ◽  
Anterior Urethra ◽  
Epithelial Metaplasia

scholarly journals The Colonic Tissue Levels of TLR2, TLR4 and Nitric Oxide in Patients with Irritable Bowel Syndrome

2016 ◽  
Vol 55 (9) ◽  
pp. 1043-1048 ◽  
Author(s):  
Erdem Koçak ◽  
Erdem Akbal ◽  
Seyfettin Köklü ◽  
Bilal Ergül ◽  
Murat Can
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Colonic Tissue ◽  
Tissue Levels ◽  
Irritable Bowel

scholarly journals Can mean ADC value and ADC ratio of benign prostate tissue to prostate cancer assist in the prediction of clinically significant prostate cancer within the PI-RADSv2 scoring system?

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Samar Ramzy Ragheb ◽  
Reem Hassan Bassiouny
Keyword(s):  
Prostate Cancer ◽  
Sensitivity And Specificity ◽  
Gleason Score ◽  
Treatment Strategies ◽  
Serum Levels ◽  
Prostatic Tissue ◽  
Histopathological Analysis ◽  
Adc Value ◽  
The Mean ◽  
Clinically Significant

Abstract Background The aim of this study is to investigate whether quantitative DW metrics can provide additive value to the reliable categorization of lesions within existing PI-RADSv2 guidelines. Fifty-eight patients with clinically suspicious prostate cancer who underwent PR examination, PSA serum levels, sextant TRUS-guided biopsies, and bi-parametric MR imaging were included in the study. Results Sixty-six lesions were detected by histopathological analysis of surgical specimens. The mean ADC values were significantly lower in tumor than non-tumor tissue. The mean ADC value inversely correlated with Gleason score of tumors with a significant p value < 0.001.Conversely, a positive relationship was found between the ADC ratio (ADC of benign prostatic tissue to prostate cancer) and the pathologic Gleason score with a significant elevation of the ADC ratio along with an increase of the pathologic Gleason score (p < 0.001). ROC curves constructed for the tumor ADC and ADC ratio helped to distinguish pathologically aggressive (Gleason score ≥ 7) from non-aggressive (Gleason score ≤ 6) tumors and to correlate it with PIRADSv2 scoring to predict the presence of clinically significant PCA (PIRADSv2 DW ≥ 4). The ability of the tumor ADC and ADC ratio to predict highly aggressive tumors (GS> 7) was high (AUC for ADC and ADC ratio, 0.946 and 0.897; p = 0.014 and 0.039, respectively). The ADC cut-off value for GS ≥ 7 was < 0.7725 and for GS ≤ 6 was > 0.8620 with sensitivity and specificity 97 and 94%. The cutoff ADC ratio for predicting (GS > 7) was 1.42 and for GS ≤ 6 was > 1.320 with sensitivity and specificity 97 and 92%. By applying this ADC ratio cut-off value the sensitivity and specificity of reader 1 for correct categorization of PIRADSv2 DW > 4 increased from 90 and 68% to 95 and 90% and that of reader 2 increased from 94 and 88% to 97 and 92%, respectively. Conclusion Estimation of DW metrics (ADC and ADC ratio between benign prostatic tissue and prostate cancer) allow the non-invasive assessment of biological aggressiveness of prostate cancer and allow reliable application of the PIRADSv2 scoring to determine clinically significant cancer (DW score > 4) which may contribute in planning initial treatment strategies.

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