Synthesis and Characterization of Synthetic and Natural Nano Hydroxyapatite Composites Containing Poloxamer Coated Demineralized Bone Matrix as Bone Graft Material: A Comparative Study

2015 ◽  
Vol 64 (10) ◽  
pp. 534-540 ◽  
Author(s):  
Santhanam Sekar ◽  
Abhishek Mandal ◽  
Ramasamy Manikandan ◽  
Samickannu Sankar ◽  
Thotapalli Parvathaleswara Sastry
Keyword(s):  
Comparative Study ◽  
Bone Graft ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Synthesis And Characterization ◽  
Graft Material ◽  
Bone Graft Material ◽  
Demineralized Bone

The Extraction Processes and Biological Characteristics of a New Generation Demineralized Bone Matrixes

2011 ◽  
Vol 217-218 ◽  
pp. 1006-1013
Author(s):  
Zhi Yu Zhou ◽  
Li Jin Zou ◽  
Hai Sheng Li ◽  
Cody Bunger ◽  
Xue Nong Zou
Keyword(s):  
Bone Graft ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Biological Characteristics ◽  
Graft Material ◽  
Bone Graft Material ◽  
Extraction Processes ◽  
Materials Used ◽  
New Generation ◽  
Demineralized Bone

An ideal bone graft material should have osteocondutive, osteroindurctive, and osteogenic features. Scientists and doctors have been trying to develop this kind of material for over one century. However, all the features of few materials used in clinic now have been qualified. Recently, COLLOSS, as the new generation bone graft material of demineralized bone matrix, almost achieved this height. The paper presents a general survey of COLLOSS including its extraction processes, biological characteristics, and application prospects.

scholarly journals Preparation and Characterization of Moldable Demineralized Bone Matrix/Calcium Sulfate Composite Bone Graft Materials

2021 ◽  
Vol 12 (4) ◽  
pp. 56
Author(s):  
I-Cheng Chen ◽  
Chen-Ying Su ◽  
Chun-Cheih Lai ◽  
Yi-Syue Tsou ◽  
Yudong Zheng ◽  
...  
Keyword(s):  
Bone Graft ◽  
Calcium Sulfate ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Washout Rate ◽  
Graft Material ◽  
Noncollagenous Proteins ◽  
Freeze Dried ◽  
Demineralized Bone ◽  
Composite Bone

Demineralized bone matrix (DBM) is a decalcified allo/xenograft retaining collagen and noncollagenous proteins, which has been extensively used because of its osteoconductive and osteoinductive properties. Calcium sulfate (CaSO4, CS) is a synthetic bone substitute used in bone healing with biocompatible, nontoxic, bioabsorbable, osteoconductive, and good mechanical characteristics. This study aims to prepare a DBM/CS composite bone graft material in a moldable putty form without compromising the peculiar properties of DBM and CS. For this purpose, firstly, porcine femur was defatted using chloroform/methanol and extracted by acid for demineralization, then freeze-dried and milled/sieved to obtain DBM powder. Secondly, the α-form and β-form of calcium sulfate hemihydrate (CaSO4 •0.5H2O, CSH) were produced by heating gypsum (CaSO4 •2H2O). The morphology and particle sizes of α- and β-CSH were obtained by SEM, and their chemical properties were confirmed by EDS, FTIR and XRD. Furthermore, the DBM-based graft was mixed with α- or β-CSH at a ratio of 9:1, and glycerol/4% HPMC was added as a carrier to produce a putty. DBM/CSH putty possesses a low washout rate, good mechanical strength and biocompatibility. In conclusion, we believe that the moldable DBM/CSH composite putty developed in this study could be a promising substitute for the currently available bone grafts, and might have practical application in the orthopedics field as a potential bone void filler.

Comparative Assessment of Autogenous Cancellous Bone Graft and Bovine-Derived Demineralized Bone Matrix for Secondary Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate

2021 ◽  
pp. 105566562110251
Author(s):  
Vijay Kumar ◽  
Vidya Rattan ◽  
Sachin Rai ◽  
Satinder Pal Singh ◽  
Jai Kumar Mahajan
Keyword(s):  
Bone Graft ◽  
Iliac Crest ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Volumetric Analysis ◽  
Group I ◽  
Alveolar Bone Grafting ◽  
Group Ii ◽  
Demineralized Bone

Objective: Comparison between bovine-derived demineralized bone matrix (DMBM) and iliac crest graft over long term for secondary alveolar bone grafting (SABG) in patients with unilateral cleft lip and palate (UCLP) in terms of radiological and clinical outcomes. Design: Prospective, randomized, parallel groups, double-blind, controlled trial. Setting: Unit of Oral and Maxillofacial Surgery, Oral Health Science Centre, Postgraduate Institute of Medical Education & Research, Chandigarh. Participants: Twenty patients with UCLP. Interventions: Patients were allocated into group I (Iliac crest bone graft) and group II (DMBM) for SABG. Outcomes were assessed at 2 weeks, 6 months, and then after mean follow-up period of 63 months. Outcomes Measures: Volumetric analysis of the grafted bone in the alveolar cleft site was done through cone beam computed tomography using Cavalieri principle and modified assessment tool. Clinical assessment was performed in terms of pain, swelling, duration of hospital stay, cost of surgery, alar base symmetry, and donor site morbidity associated with iliac crest harvesting. Results: Volumetric analysis through Cavalieri principle revealed comparable bone uptake at follow-up of 6 months between group I (70%) and group II (69%). Modified assessment tool showed no significant difference between horizontal and vertical bone scores over short- and long-term follow-up. In group II, there was higher cost of surgery, but no donor site morbidity unlike group I. Conclusions: Demineralized bone matrix proved analogous to iliac crest bone graft as per volumetric analysis over shorter period. However, although statistically insignificant, net bone volume achieved was lower than the iliac crest graft at longer follow-up.

scholarly journals Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/borax /CaCO3 and Demineralized Bone Matrix

2021 ◽  
Author(s):  
Daniela Medrano-David ◽  
Aura Maria Lopera ◽  
Martha Elena Londoño ◽  
Pedronel Araque-Marín
Keyword(s):  
Bone Substitute ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Particulate Material ◽  
Bone Tissue Regeneration ◽  
Bone Implant ◽  
Injectable Scaffold ◽  
The World ◽  
Demineralized Bone

The occurrence of bone-related disorders and diseases has increased dramatically in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision, in addition, these particles are susceptible to migrate to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill the bone defect. The aim of this research is to develop a DBM carrier with such viscoelastic properties to obtain an injectable bone substitute (IBS). The DBM carrier developed consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by the injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results show that the developed material has great potential to be used in bone tissue regeneration

Characterization of Bone Defect Repair in Young and Aged Rat Femur Induced by Xenogenic Demineralized Bone Matrix

2002 ◽  
Vol 73 (9) ◽  
pp. 1003-1009 ◽  
Author(s):  
Paola Torricelli ◽  
Milena Fini ◽  
Gianluca Giavaresi ◽  
Lia Rimondini ◽  
Roberto Giardino
Keyword(s):  
Bone Defect ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Rat Femur ◽  
Aged Rat ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Demineralized Bone
Sign in / Sign up

Export Citation Format

Share Document