pH and GSH dual-responsive fluorescent nanoparticles from polydopamine coating mesoporous silica for controlled drug release and real-time detection

2021 ◽  
pp. 1-10
Author(s):  
Hengquan Zhou ◽  
Guiying Li ◽  
Lei Guo ◽  
Qian Tao ◽  
Songmei Ma ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Real Time ◽  
Controlled Drug Release ◽  
Fluorescent Nanoparticles ◽  
Dual Responsive ◽  
Real Time Detection

scholarly journals Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (37) ◽  
pp. 20862-20871 ◽  
Author(s):  
Chao Chen ◽  
Wen Sun ◽  
Wenji Yao ◽  
Yibing Wang ◽  
Hanjie Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Polymer Shell ◽  
Dual Responsive

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and delivery

Nanomedicine ◽  
2020 ◽  
Vol 15 (25) ◽  
pp. 2447-2458
Author(s):  
Xiaona Li ◽  
Shun Hu ◽  
Zhe Lin ◽  
Jie Yi ◽  
Xue Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Aldehyde Group ◽  
Real Time Monitoring ◽  
Dual Responsive

Aim: Smart mesoporous silica nanoparticles (MSNs) coated with carbon dots (CDs) and poly(N-vinylcaprolactam) (PNVCL) as a mixed shell (CDs/PNVCL polymer grafted MSNs) were prepared for pH-trigged anticancer drug release and real-time monitoring. Materials & methods: The amino-terminated PNVCL and amino-rich CDs were grafted onto the surface of aldehyde group functionalized MSNs through Schiff base reaction. Doxorubicin (DOX) was loaded into the prepared nanoparticles. Results: DOX could be quickly released in the tumor environment, leading to cell apoptosis. The linear fit between the percentage of released DOX and the fluorescence intensity of CDs indicated that the change in fluorescence intensity could be used to monitor drug release in real time. Conclusion: The as-prepared CDs/PNVCL polymer grafted MSNs are promising candidates for integrating controllable release and real-time monitoring in cancer treatment.

scholarly journals AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (60) ◽  
pp. 34958-34962 ◽  
Author(s):  
Lu Zhou ◽  
Guojie Liu ◽  
Yang Wang ◽  
Jianling Liu ◽  
Yajie Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

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