In Vivo and In Vitro Antıneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives

2013 ◽  
Vol 65 (4) ◽  
pp. 515-526 ◽  
Author(s):  
Sumeyya Akyol ◽  
Gulfer Ozturk ◽  
Zeynep Ginis ◽  
Ferah Armutcu ◽  
M. Ramazan Yigitoglu ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Formulation development of folic acid conjugated PLGA nanoparticles for improved cytotoxicity of Caffeic acid phenethyl ester

2021 ◽  
Vol 09 ◽  
Author(s):  
Harshad S Kapare ◽  
Sathiyanarayanan L ◽  
Arulmozhi S ◽  
Kakasaheb Mahadik
Keyword(s):  
Folic Acid ◽  
Drug Release ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Therapeutic Effects ◽  
Formulation Development ◽  
Sustained Drug Release ◽  
Active Constituent

Background: Honey bee propolis is one of the natural product reported in various traditional systems of medicines including Ayurveda. Caffeic acid phenethyl ester (CAPE) is an active constituent of propolis which is well known for its anticancer potential. The therapeutic effects of CAPE are restricted owing to its less aqueous solubility and low bioavailability. Objective: In this study CAPE loaded folic acid conjugated nanoparticle system (CLFPN) was investigated to enhance solubility, achieve sustained drug release and improved cytotoxicity of CAPE. Methods: Formulation development, characterization and optimization were carried out by design of experiment approach. In vitro and in vivo cytotoxicity study was carried out for optimized formulations. Results: Developed nanoparticles showed particle size and encapsulation efficiency of 170 ± 2 - 195 ± 3 nm and 75.66 ± 1.52 - 78.80 ± 1.25 % respectively. Optimized formulation CLFPN showed sustained drug release over a period of 42 h. GI50 concentration was decreased by 46.09% for formulation as compared to CAPE in MCF-7 cells indicating targeting effect of CLFPN. An improved in vitro cytotoxic effect was reflected in in-vivo Daltons Ascites Lymphoma model by reducing tumor cells count. Conclusion: The desired nanoparticle characteristic with improved in vivo and in vitro cytotoxicity was shown by developed formulation. Thus it can be further investigated for biomedical applications.

In Vitro and in Vivo Stability of Caffeic Acid Phenethyl Ester, a Bioactive Compound of Propolis

2007 ◽  
Vol 55 (9) ◽  
pp. 3398-3407 ◽  
Author(s):  
Nicola Celli ◽  
Luana K. Dragani ◽  
Stefania Murzilli ◽  
Tommaso Pagliani ◽  
Andreina Poggi
Keyword(s):  
Caffeic Acid ◽  
Bioactive Compound ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2370
Author(s):  
Jia Wang ◽  
Priyanshu Bhargava ◽  
Yue Yu ◽  
Anissa Nofita Sari ◽  
Huayue Zhang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Caffeic Acid ◽  
Treated Group ◽  
Caffeic Acid Phenethyl Ester ◽  
Caspase Cleavage ◽  
Unique Cell

Caffeic acid phenethyl ester (CAPE) is a key bioactive ingredient of honeybee propolis and is claimed to have anticancer activity. Since mortalin, a hsp70 chaperone, is enriched in a cancerous cell surface, we recruited a unique cell internalizing anti-mortalin antibody (MotAb) to generate mortalin-targeting CAPE nanoparticles (CAPE-MotAb). Biophysical and biomolecular analyses revealed enhanced anticancer activity of CAPE-MotAb both in in vitro and in vivo assays. We demonstrate that CAPE-MotAb cause a stronger dose-dependent growth arrest/apoptosis of cancer cells through the downregulation of Cyclin D1-CDK4, phospho-Rb, PARP-1, and anti-apoptotic protein Bcl2. Concomitantly, a significant increase in the expression of p53, p21WAF1, and caspase cleavage was obtained only in CAPE-MotAb treated cells. We also demonstrate that CAPE-MotAb caused a remarkably enhanced downregulation of proteins critically involved in cell migration. In vivo tumor growth assays for subcutaneous xenografts in nude mice also revealed a significantly enhanced suppression of tumor growth in the treated group suggesting that these novel CAPE-MotAb nanoparticles may serve as a potent anticancer nanomedicine.

Antimicrobial medical sutures with caffeic acid phenethyl ester and their in vitro/in vivo biological assessment

MedChemComm ◽  
2013 ◽  
Vol 4 (5) ◽  
pp. 777 ◽  
Author(s):  
Hye Sun Lee ◽  
Soo Youn Lee ◽  
So Hyun Park ◽  
Jin Hyung Lee ◽  
Sang Kook Ahn ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Biological Assessment

Caffeic acid phenethyl ester, a coffee polyphenol, inhibits DNA methylation in vitro and in vivo

2020 ◽  
Vol 887 ◽  
pp. 173464 ◽  
Author(s):  
Pan Wang ◽  
Noriko Yamabe ◽  
Can-Jian Hong ◽  
Hyoung-Woo Bai ◽  
Bao Ting Zhu
Keyword(s):  
Dna Methylation ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo

2017 ◽  
Vol 111 (7) ◽  
pp. 388-394
Author(s):  
Nazeh M. Al-Abd ◽  
Zurainee Mohamed Nor ◽  
Quazim O. Junaid ◽  
Marzida Mansor ◽  
M. S. Hasan ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Brugia Pahangi ◽  
Antifilarial Activity

Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo

2006 ◽  
Vol 234 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Hsing-Chun Kuo ◽  
Wu-Hsien Kuo ◽  
Yean-Jang Lee ◽  
Wea-Lung Lin ◽  
Fen-Pi Chou ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Glioma Cells ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
C6 Glioma ◽  
C6 Glioma Cells

scholarly journals Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo

2019 ◽  
Vol 20 (6) ◽  
pp. 1468 ◽  
Author(s):  
Chin-Chang Cheng ◽  
Pei-Ling Chi ◽  
Min-Ci Shen ◽  
Chih-Wen Shu ◽  
Shue-Ren Wann ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Caffeic Acid ◽  
Systolic Pressure ◽  
Caffeic Acid Phenethyl Ester ◽  
Pulmonary Hemodynamic ◽  
Pulmonary Arterial

Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial proliferation and remodeling, resulting in a specific increase in right ventricle systolic pressure (RVSP) and, ultimately right ventricular failure. Recent studies have demonstrated that caffeic acid phenethyl ester (CAPE) exerts a protective role in NF-κB-mediated inflammatory diseases. However, the effect of CAPE on PAH remains to be elucidated. In this study, monocrotaline (MCT) was used to establish PAH in rats. Two weeks after the induction of PAH by MCT, CAPE was administrated by intraperitoneal injection once a day for two weeks. Pulmonary hemodynamic measurements and pulmonary artery morphological assessments were examined. Our results showed that administration of CAPE significantly suppressed MCT-induced vascular remodeling by decreasing the HIF-1α expression and PDGF-BB production, and improved in vivo RV systolic performance in rats. Furthermore, CAPE inhibits hypoxia- and PDGF-BB-induced HIF-1α expression by decreasing the activation of the AKT/ERK pathway, which results in the inhibition of human pulmonary artery smooth muscle cells (hPASMCs) proliferation and prevention of cells resistant to apoptosis. Overall, our data suggest that HIF-1α is regarded as an alternative target for CAPE in addition to NF-κB, and may represent a promising therapeutic agent for the treatment of PAH diseases.

scholarly journals Caffeic acid phenethyl ester decreases acute pneumonitis after irradiation in vitro and in vivo

BMC Cancer ◽  
2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Miao-Fen Chen ◽  
Peter C Keng ◽  
Paul-Yang Lin ◽  
Cheng-Ta Yang ◽  
Shuen-Kuei Liao ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester
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