scholarly journals Epicatechin Gallate Induces Cell Death via p53 Activation and Stimulation of p38 and JNK in Human Colon Cancer SW480 Cells

2013 ◽  
Vol 65 (5) ◽  
pp. 718-728 ◽  
Author(s):  
Isabel Cordero-Herrera ◽  
María Angeles Martín ◽  
Laura Bravo ◽  
Luis Goya ◽  
Sonia Ramos
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Human Colon ◽  
Epicatechin Gallate ◽  
Human Colon Cancer ◽  
P53 Activation ◽  
Sw480 Cells ◽  
Stimulation Of

SiRNA-mediated IGF-1R inhibition sensitizes human colon cancer SW480 cells to radiation

2009 ◽  
Vol 49 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Kamal Yavari ◽  
Mohammad Taghikhani ◽  
Mohammad Ghannadi Maragheh ◽  
Seyed A. Mesbah-Namin ◽  
Mohammad Hosein Babaei ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Sw480 Cells

Apoptotic Effect of Saccharomyces cerevisiae on Human Colon Cancer SW480 Cells by Regulation of Akt/NF-ĸB Signaling Pathway

2019 ◽  
Vol 12 (1) ◽  
pp. 311-319 ◽  
Author(s):  
Sara Shamekhi ◽  
Jalal Abdolalizadeh ◽  
Alireza Ostadrahimi ◽  
Seyyed Abolghasem Mohammadi ◽  
Abolfazl Barzegari ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Colon Cancer ◽  
Signaling Pathway ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Apoptotic Effect ◽  
Sw480 Cells

scholarly journals Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression

Cell Cycle ◽  
2009 ◽  
Vol 8 (3) ◽  
pp. 473-481 ◽  
Author(s):  
Sabina Pucci ◽  
Paola Mazzarelli ◽  
Fabiola Sesti ◽  
David A. Boothman ◽  
Luigi G. Spagnoli
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Progression ◽  
Interleukin 6 ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Progression

scholarly journals Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

2019 ◽  
Vol 20 (11) ◽  
pp. 2723 ◽  
Author(s):  
Giuseppe Antonio Malfa ◽  
Barbara Tomasello ◽  
Rosaria Acquaviva ◽  
Carlo Genovese ◽  
Alfonsina La Mantia ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Death ◽  
Cell Viability ◽  
Lipid Hydroperoxide ◽  
Human Colon ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Human Colon Cancer ◽  
Cellular Redox

Betula etnensis Raf. (Birch Etna) belonging to the Betulaceae family grows on the eastern slope of Etna. Many bioactive compounds present in Betula species are considered promising anticancer agents. In this study, we evaluated the effects of B. etnensis Raf. bark methanolic extract on a human colon cancer cell line (CaCo2). In order to elucidate the mechanisms of action of the extract, cellular redox status, cell cycle, and heme oxygenase-1 (HO-1) expression in ferroptosis induction were evaluated. Cell viability and proliferation were tested by tetrazolium (MTT) assayand cell cycle analysis, while cell death was evaluated by annexin V test and lactic dehydrogenase (LDH) release. Cellular redox status was assessed by measuring thiol groups (RSH) content, reactive oxygen species (ROS) production, lipid hydroperoxide (LOOH) levels and (γ-glutamylcysteine synthetase) γ-GCS and HO-1 expressions. The extract significantly reduced cell viability of CaCo2, inducing necrotic cell death in a concentration-depending manner. In addition, an increase in ROS levels and a decrease of RSH content without modulation in γ-GCS expression were detected, with an augmentation in LOOH levels and drastic increase in HO-1 expression. These results suggest that the B. etnensis Raf. extract promotes an oxidative cellular microenvironment resulting in CaCo2 cell death by ferroptosis mediated by HO-1 hyper-expression.

scholarly journals INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells

Neoplasma ◽  
2014 ◽  
Vol 61 (01) ◽  
pp. 56-62 ◽  
Author(s):  
H. J. An ◽  
E. K. Choi ◽  
J. S. Kim ◽  
S. W. Hong ◽  
J. H. Moon ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Human Colon ◽  
Apoptotic Cell Death ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells

2017 ◽  
Vol 51 (4) ◽  
pp. 1169-1178 ◽  
Author(s):  
Kyoung Ah Kang ◽  
Mei Jing Piao ◽  
Yea Seong Ryu ◽  
Yu Jae Hyun ◽  
Jeong Eon Park ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antioxidant Activity ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Human Colon ◽  
Apoptotic Cell Death ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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