MIXED MICELLES OF CATIONIC SURFACTANTS IN AQUEOUS POLYETHYLENE GLYCOL 1000

1999 ◽  
Vol 20 (7) ◽  
pp. 1715-1735 ◽  
Author(s):  
Mandeep Singh Bakshi
Keyword(s):  
Polyethylene Glycol ◽  
Cationic Surfactants ◽  
Mixed Micelles ◽  
Polyethylene Glycol 1000

Resveratrol-piperine loaded mixed micelles: formulation, characterization, bioavailability, safety and in vitro anticancer activity

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 112795-112805 ◽  
Author(s):  
Prakash Jadhav ◽  
C. Bothiraja ◽  
Atmaram Pawar
Keyword(s):  
Polyethylene Glycol ◽  
Anticancer Activity ◽  
Oral Bioavailability ◽  
Mixed Micelles ◽  
Poloxamer 407 ◽  
Polyethylene Glycol 1000

Novel RES-carrying piperine loaded mixed micelles (RES-P-MM) composed of Poloxamer 407 and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were developed to enhance the solubility, oral bioavailability and anticancer potency of RES.

scholarly journals In VitroCharacterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Adeel Masood Butt ◽  
Mohd Cairul Iqbal Mohd Amin ◽  
Haliza Katas ◽  
Narong Sarisuta ◽  
Wasu Witoonsaridsilp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Mixed Micelles ◽  
Chemotherapeutic Agents ◽  
Pluronic F127 ◽  
Breast Adenocarcinoma ◽  
Anticancer Drug Delivery ◽  
Polyethylene Glycol 1000

Mixed micelles of Pluronic F127 andD-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic agents. Their size, zeta potential, critical micelle concentration, drug loading content, entrapment efficiency, drug release, cytotoxicity, and stability in serum were evaluatedin vitroby using doxorubicin as the model anticancer drug. The micellar sizes ranged from 25 to 35 nm. The 7 : 3 and 5 : 5 micellar combinations had lower critical micelle concentrations ( M) than the 10 : 0 combination ( M). The entrapment efficiencies of the 7 : 3, 5 : 5, and 3 : 7 micellar combinations were 72%, 88%, and 69%, respectively. Doxorubicin release was greater at acidic tumour pH than at normal physiological pH. The doxorubicin-loaded mixed micelles showed greater percent inhibition and apoptosis activity in human breast adenocarcinoma (MCF-7) and acute monocytic leukaemia (THP-1) cell lines than free doxorubicin did. The mixed micelles were also stable against aggregation and precipitation in serum. These findings suggest that Pluronic F127-TPGS mixed micelles could be used as nanocarriers for targeted anticancer-drug delivery.

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

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