Intraventricular administration of antibiotics by ommaya reservoir for patients with multidrug-resistant Acinetobacter baumannii central nervous system infection

2020 ◽  
pp. 1-4
Author(s):  
Yue Chen ◽  
Lei Liu ◽  
Man Zhu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Central Nervous System Infection ◽  
Multidrug Resistant ◽  
Ommaya Reservoir ◽  
Intraventricular Administration

scholarly journals Intrathecal Colistin and Intravenous Fosfomycin as a combination therapy for the treatment of Acinetobacter baumannii Ventriculitis and meningitis: a case report from Nepal

2021 ◽  
Vol 18 (4) ◽  
pp. 39-43
Author(s):  
Bikash Khadka ◽  
Saroj Poudel
Keyword(s):  
Central Nervous System ◽  
Drug Resistance ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Central Nervous System Infection ◽  
Multi Drug Resistance ◽  
Intraventricular Administration ◽  
Successful Management ◽  
Initial Regimen ◽  
Cns Penetration

Treatment of central nervous system infection may be troublesome due to multi-drug resistance. Colistin is less successful as a treatment option due to poor CNS penetration when used intravenously. We present the successful management of a case with ventriculitis and meningitis due to MDR Acinetobacter baumannii species with the combined intraventricular administration of colistin and IV fosfomycin after the initial regimen of colistin given alone through both IVT and IV routes had failed.

scholarly journals Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Mohamad Yasmin ◽  
Jennifer Hanrahan ◽  
Steven Marshall ◽  
Thomas P Lodise ◽  
Liang Chen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Drug Monitoring ◽  
Klebsiella Pneumoniae ◽  
Drug Monitoring ◽  
Central Nervous System Infection ◽  
Multidrug Resistant ◽  
Therapeutic Drug ◽  
Central Nervous System Infections ◽  
Klebsiella Pneumoniae Carbapenemase

Abstract This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)–3–producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC–Klebsiella pneumoniae central nervous system infections.

scholarly journals Combined Intravenous and Intraventricular Administration of Colistin Methanesulfonate in Critically Ill Patients with Central Nervous System Infection

2013 ◽  
Vol 57 (4) ◽  
pp. 1938-1940 ◽  
Author(s):  
Mairi Ziaka ◽  
Sophia L. Markantonis ◽  
Marizoza Fousteri ◽  
Paris Zygoulis ◽  
Dimitris Panidis ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Critically Ill ◽  
Intravenous Administration ◽  
Critically Ill Patients ◽  
External Ventricular Drain ◽  
Central Nervous System Infection ◽  
Intraventricular Administration ◽  
Colistin Methanesulfonate

ABSTRACTColistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls,n= 5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv,n= 3) or combined intravenous/intraventricular administration (EVDVcomb,n= 4). Cerebrospinal fluid (CSF)/serum colistin concentration ratios were higher in EVDViv than in control patients (11% versus 7%,P≤ 0.05) and in EVDVcomb compared to all other patients (P< 0.0001). CSF colistin concentrations above the MIC of 0.5 μg/ml were achieved only in EVDVcomb patients.

Infection of a Shunt by Mycobacterium fortuitum: Case Report

Neurosurgery ◽  
1991 ◽  
Vol 29 (3) ◽  
pp. 472-474 ◽  
Author(s):  
Kwan-Hon Chan ◽  
Kirpal S. Mann ◽  
W. H. Seto
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Obstructive Hydrocephalus ◽  
Central Nervous System Infection ◽  
Shunt Infection ◽  
Mycobacterium Fortuitum ◽  
Intraventricular Administration ◽  
Ventriculoatrial Shunt ◽  
Pertinent Literature

Abstract Mycobacterium fortuitum is a rare cause of central nervous system infection: however, shunt infection caused by this organism has not been reported. We report a case of shunt infection subsequent to insertion of a ventriculoatrial shunt for obstructive hydrocephalus caused by a cerebellar hematoma. The shunt infection was controlled by removal of the shunt and a combination of systemic and intraventricular administration of amikacin, and oral administration of ofloxacin. The case is discussed and the pertinent literature reviewed.

scholarly journals Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant Acinetobacter baumannii

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052092040 ◽  
Author(s):  
Liang-Ming Li ◽  
Wen-Jian Zheng ◽  
Shang-Wen Shi
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Adverse Reactions ◽  
Central Nervous System Infection ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Spinal Arachnoiditis ◽  
Safe Dose

In prior research, intrathecal tigecycline was successfully used to treat central nervous system infection by extensively drug-resistant Acinetobacter baumannii. However, little is known about its safe dose and adverse reactions. This study reports the case of a 28-year-old male patient who was diagnosed with central nervous system infection by extensively drug-resistant A. baumannii after the removal of a ventriculoperitoneal shunt. Intravenous and intrathecal tigecycline were administrated simultaneously. Spinal arachnoiditis was discovered after nine doses of intrathecal tigecycline. Spinal arachnoiditis was resolved after discontinuation of the antibiotic. This is the first report of an adverse reaction to intrathecal tigecycline. The case was complicated by spinal arachnoiditis, which obstructed the assessment of cerebrospinal fluid. The appropriate dose and administration schedule of intrathecal tigecycline remain to be determined.

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