Combined Intravenous and Intraventricular Administration of Colistin Methanesulfonate in Critically Ill Patients with Central Nervous System Infection
2013 ◽
Vol 57
(4)
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pp. 1938-1940
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Keyword(s):
ABSTRACTColistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls,n= 5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv,n= 3) or combined intravenous/intraventricular administration (EVDVcomb,n= 4). Cerebrospinal fluid (CSF)/serum colistin concentration ratios were higher in EVDViv than in control patients (11% versus 7%,P≤ 0.05) and in EVDVcomb compared to all other patients (P< 0.0001). CSF colistin concentrations above the MIC of 0.5 μg/ml were achieved only in EVDVcomb patients.
2014 ◽
Vol 44
(5)
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pp. 409-415
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1988 ◽
Vol 7
(3)
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pp. 374-380
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2019 ◽
pp. 319-324
2017 ◽
Vol 4
(1)
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pp. 25-31
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2014 ◽
Vol 53
(1)
◽
pp. 319-322
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