Soy Isoflavones: No Effects on Bone Mineral Content and Bone Mineral Density in Healthy, Menstruating Young Adult Women after One Year

2002 ◽  
Vol 21 (5) ◽  
pp. 388-393 ◽  
Author(s):  
John J. B. Anderson ◽  
Xiaowei Chen ◽  
Agna Boass ◽  
Michael Symons ◽  
Martin Kohlmeier ◽  
...  
1996 ◽  
Vol 82 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Sandro Barni ◽  
Paolo Lissoni ◽  
Gabriele Tancini ◽  
Antonio Ardizzoia ◽  
Marina Cazzaniga

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.


2013 ◽  
Vol 16 (2) ◽  
pp. 129-130 ◽  
Author(s):  
Eddy Zakhem ◽  
Rawad El Hage ◽  
Sarah Bassil ◽  
Elie Moussa ◽  
Gautier Zunquin ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document