Isi Piringku Dietary Meal Proportion Estimator Applications using SeeFood Image Segmentations

Isi Piringku atau My Meal Dish Content was a program initiated by the Indonesian ministry of health to promote a healthy daily lifestyle consisting of balanced dietary, enough hydration, active lifestyle, cleanliness and body weight control. The balanced diet meal was supposed to consist of ⅓ of carbohydrate intake, ⅓ of vegetable intake, ⅙ of fruit intake and ⅙ of protein intake every time. This introduces some difficulty that every meal must be measured to align with the dietary guidelines. This study targets estimating the meal diet proportion by its visual cues using smartphone application. While the actual meal content dietary division was weight based, for sake of simplicity the proportion in this study was estimated by each food area which roughly correlates to its volume. Using smartphone cameras in Android 9 Operating Systems and Tensorflow Lite Seefoods: Mobile Food Segmentation v1.0 module, an application was built to help users estimate their meal balances proportion. The original segmentation criterion was constructed using USDA dietary guidelines and it was reduced to only 4 food groups related to Isi Piringku criterion. Suggestion will be given regarding the segmentation result. The result was that the application was capable of estimating the meal diet proportion and giving suggestions based on the segmentation result. Although, the volume of the meal food groups estimated was still low on accuracy. This was correlated with the accuracy level of the segmentation module that was used. On average, the time needed to apply the segmentation process was around 2 to 3 seconds on a Snapdragon 835 device.

Effect of Silicon Dioxide Nanoparticles on Liver Morphology of Rats in Parenteral Administration

The issue of the potential safety of silicon dioxide nanoparticles (SDNPs) remains relevant. In this connection, in order to use the unique capabilities of silicon nanostructures for biomedical purposes, as well as to level their toxic effects, a detailed study of these nanoparticles interaction with cells and tissues in vivo is required.The aim of the research is to reveal morphofunctional changes in a rat's liver after a single parenteral administration of 12 nm silicon dioxide nanoparticles for the period of six months.Material and methods. Using general histological and immunohistochemical methods to study the rats' liver after a single parenteral administration of 1 ml of silicon dioxide nanoparticles at a dose of 7 mg/kg of body weight at a concentration of 2 mg/ml. The sections of the rats' liver were studied by general histological and immunohistochemical methods after injection of 1mL of a SDNPs saline suspension at a concentration of 2 mg/mL (7mg/kg of body weight). Control animals were injected with 1 ml of saline solution. The material was collected in 21 days, 2, 4 and 6 months months after the administration of the SDNPs and it was fixed in 10% neutral formaldehyde.Results. The formation of granulomas in the liver on the 21st day of the experiment and an increase in the number of Kupfer cells were revealed. However, by the 2nd month of the experiment, the number of granulomas significantly decreases compared to the 21st day of the experiment and continues to decrease in subsequent periods. The average size of granulomas decreases during the 2nd month of the experiment and does not change during the subsequent periods of the experiment. After 6 months of the experiment, the morphofunctional state of the liver is characterized by slightly pronounced aseptic inflammation.Conclusion. A single parenteral administration of silicon dioxide nanoparticles causes pronounced aseptic inflammation of the liver, decreasing by the 6th month of the experiment. Connective tissue remodeling in the liver is not observed at all periods of the experiment.

The Association between Trajectories of Anthropometric Variables and Risk of Diabetes among Prediabetic Chinese

In order to explore the association between trajectories of body mass index (BMI) and mid-upper arm circumference (MUAC) and diabetes and to assess the effectiveness of the models to predict diabetes among Chinese prediabetic people, we conducted this study. Using a national longitudinal study, 1529 cases were involved for analyzing the association between diabetes and BMI trajectories or MUAC trajectories. Growth mixture modeling was conducted among the prediabetic Chinese population to explore the trajectories of BMI and MUAC, and logistic regression was applied to evaluate the association between these trajectories and the risk of diabetes. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were applied to assess the feasibility of prediction. BMI and MUAC were categorized into 4-class trajectories, respectively. Statistically significant associations were observed between diabetes in certain BMI and MUAC trajectories. The AUC for trajectories of BMI and MUAC to predict diabetes was 0.752 (95% CI: 0.690–0.814). A simple cross-validation using logistic regression indicated an acceptable efficiency of the prediction. Diabetes prevention programs should emphasize the significance of body weight control and maintaining skeletal muscle mass and resistance training should be recommended for prediabetes.

Eye temperature, an indicator for stress levels in young buffalo bulls – A case study of micro-environment modification

The present study was undertaken with an objective to determine diurnal changes of the eye temperature of buffalo young bulls under different shelter management to determine the effect of heat stress. Twenty four buffalo bulls were randomly divided into two groups, each group comprising of 12 animals based on age (16–18 months) and body weight (Control = 301 ± 8.24 kg and Treatment = 311.45 ± 6.24 kg). The control group was housed under normal management practices followed, and the height of the shed was 10 ft. and width was 12 ft. with concrete floor. Whereas, the treatment group was housed in shed having 15 ft. height and 25 ft. width along with rubber mat as flooring and the total area provided for each animal in both the groups was 45.96 sq. feet. They were also provided with dairy fans and mist cooling in day time to ameliorate the heat stress. The thermal humidity index (THI), floor and roof temperature variation of the shed was recorded. The eye temperature of bulls was measured to evaluate the effect of different housing on the animals’ thermal status under hot dry summer conditions.Results revealed that the THI of treatment shed was significantly (P< 0.01) lower than the control at different times. The floor and roof surface temperature of the treatment shed was significantly (P<0.05) lower than the control shed. Diurnal patterns of eye temperature measured in both the groups showed increased eye temperature in control group bulls compared to treatment group. The eye temperature at 7.00 hrs was similar in both groups, whereas it was highly significant (P<0.01) at 13.00 and 19.00 hrs. The heat stress in the buffalo bulls was exhibited by increased eye temperature. Thus, the variation in the eye temperature can be effectively used as an indicator of heat stress and the dairy fans and mist cooling along with rubber mat flooring can be utilized to ameliorate the heat stress in the buffalo bulls.

A Short S-Equol Exposure Has a Long-Term Inhibitory Effect on Adipogenesis in Mouse 3T3-L1 Cells

In the search for new drugs against obesity, the chronic disease that threatens human health worldwide, several works have focused on the study of estrogen homologs because of the role of estrogen receptors (ERs) in adipocyte growth. The isoflavone equol, an ERβ agonist, has shown beneficial metabolic effects in in vivo and in vitro assays; however, additional studies are required to better characterize its potential for body weight control. Here, we showed that the treatment of 3T3-L1 cells with 10 μM of S-equol for the first three days of the adipocyte differentiation protocol was able to prevent cells becoming semi-rounded and having a lipid droplet formation until the seventh day of culture; moreover, lipid accumulation was reduced by about 50%. Congruently, S-equol induced a reduction in mRNA expression of the adipogenic markers C/EBPα and PPARγ, and adipokines secretion, mainly Adiponectin, Leptin, Resistin, and MCP-1, while the release of PAI-1 was augmented. Moreover, it also reduced the expression of ERα and attenuated the subexpression of ERβ associated with adipogenesis. Altogether, our data suggested that S-equol binding to ERβ affects the transcriptional program that regulates adipogenesis and alters adipocyte functions. Future efforts will focus on studying the impact of S-equol on ER signaling pathways.

Efficacy and safety of semaglutide in glycemic control, body weight management, lipid profiles and other biomarkers among obese type 2 diabetes patients initiated or switched to semaglutide from other GLP-1 receptor agonists

Purpose Evidence of the efficacy and safety of semaglutide among patients with type 2 diabetes who were initiated on or were switched to semaglutide from other GLP-1 RAs remains limited. The objective of this study was to investigate the short-term effects of switching to semaglutide from other GLP-1 RAs. Methods This retrospective cohort study evaluated patients with type 2 diabetes who were initiated on or were switched to semaglutide due to poor diabetes control with other GLP-1 RAs or other medications, or obesity. HbA1c, body weight, serum creatinine, serum uric acid, parameters of lipid metabolism, and parameters of liver function were measured before and 6 months after administration of semaglutide. Results A total of 50 patients were registered in the study. After switching to semaglutide (n = 43), HbA1c and body weight significantly decreased (p < 0.01, p < 0.01), respectively. The same findings were observed in semaglutide-naïve patients (p = 0.04, p < 0.02) (n = 7). Serum uric acid, total cholesterol, triglycerides, and urinary albumin-creatinine ratio decreased significantly as well (p = 0.04, p = 0.04, p = 0.02, p = 0.04), whereas serum creatinine did not change significantly (p = 0.51). Conclusions Semaglutide showed excellent efficacy, even in patients switched from other GLP-1 RAs. Semaglutide appears to be a promising agent for blood glucose and body weight control in obese type 2 diabetes mellitus patients and could be more potent in treating type 2 diabetes than existing GLP-1 RAs.

The Synthesis and Evaluation of RGD−Conjugated Chitosan Gel as Daily Supplement for Body Weight Control

(1) Background: Obesity is one of the most widespread chronic diseases and increases the risk of several other chronic diseases, especially type 2 diabetes. (2) Methods: Endobarrier is a new medical device what is worn in the small intestines for the treatment of type 2 diabetes and obesity. However, given the invasive and other adverse effects of the Endobarrier, we propose the use of RGD peptide conjugated with chitosan (RC) as an alternative. (3) Results: The FTIR and NMR spectrum showed RGD peptide was successfully conjugated on chitosan and RGD−CT is retained in the small intestine even after digestion. In vitro of wst-1 and live and dead staining studies show that the RGD−CT gel is highly biocompatible and non-toxic. Rats treated with the RGD−CT gel for a short term showed significant decrease change more than 30% in body weight, while the blood and hematic biometrics were within normal values. (4) Conclusions: The RGD−CT gel is safe, suitable for the short-term, reducing visceral fat rate health food to control weight. In the future, it is expected to develop a safe, long-term effective, flexibility of use and low-side-effect anti-obesity therapy in the era of precision medicine by further modification.

CLINICAL STATUS AND BURDEN OF ATRIAL FIBRILLATION IN OBESE INDIVIDUALS: ASSESSING THE EFFECTS OF BODY WEIGHT CONTROL PROGRAMS

Correction of modifiable risk factors is the most promising direction of modern scientific research in the field of atrial fibrillation