Screening of the structural, topological, and electronic properties of the functionalized Graphene nanosheets as potential Tegafur anticancer drug carriers using DFT method

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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Preparation ofN-Isopropylacrylamide/Itaconic Acid Magnetic Nanohydrogels by Modified Starch as a Crosslinker for Anticancer Drug Carriers

International Journal of Polymeric Materials ◽

10.1080/00914037.2014.996703 ◽

2015 ◽

Vol 64 (10) ◽

pp. 541-549 ◽

Cited By ~ 32

Author(s):

Marziyeh Fathi ◽

Ali Akbar Entezami ◽

Sanam Arami ◽

Mohammad-Reza Rashidi

Keyword(s):

Anticancer Drug ◽

Itaconic Acid ◽

Drug Carriers ◽

Modified Starch

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Lactobionic acid and carboxymethyl chitosan functionalized graphene oxide nanocomposites as targeted anticancer drug delivery systems

Carbohydrate Polymers ◽

10.1016/j.carbpol.2016.06.024 ◽

2016 ◽

Vol 151 ◽

pp. 812-820 ◽

Cited By ~ 64

Author(s):

Qixia Pan ◽

Yao Lv ◽

Gareth R. Williams ◽

Lei Tao ◽

Huihui Yang ◽

...

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Anticancer Drug ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Carboxymethyl Chitosan ◽

Functionalized Graphene ◽

Functionalized Graphene Oxide ◽

Lactobionic Acid ◽

Anticancer Drug Delivery

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Tribological behavior of dodecylamine functionalized graphene nanosheets dispersed engine oil nanolubricants

Tribology International ◽

10.1016/j.triboint.2018.11.012 ◽

2019 ◽

Vol 131 ◽

pp. 605-619 ◽

Cited By ~ 16

Author(s):

Gayatri Paul ◽

Subhasis Shit ◽

Harish Hirani ◽

Tapas Kuila ◽

N.C. Murmu

Keyword(s):

Tribological Behavior ◽

Graphene Nanosheets ◽

Engine Oil ◽

Functionalized Graphene

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Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

Bubble Science Engineering & Technology ◽

10.1179/175889709x446516 ◽

2009 ◽

Vol 1 (1-2) ◽

pp. 31-39 ◽

Cited By ~ 70

Author(s):

N. Y. Rapoport ◽

A. L. Efros ◽

D. A. Christensen ◽

A. M. Kennedy ◽

K.-H. Nam

Keyword(s):

Phase Shift ◽

Anticancer Drug ◽

Drug Carriers

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High-Performance Thermal Management Nanocomposites: Silver Functionalized Graphene Nanosheets and Multiwalled Carbon Nanotube

Crystals ◽

10.3390/cryst8110398 ◽

2018 ◽

Vol 8 (11) ◽

pp. 398 ◽

Cited By ~ 4

Author(s):

Yongcun Zhou ◽

Xiao Zhuang ◽

Feixiang Wu ◽

Feng Liu

Keyword(s):

Thermal Conductivity ◽

Carbon Nanotube ◽

Polymer Composites ◽

Thermal Management ◽

High Performance ◽

Graphene Nanosheets ◽

Multiwalled Carbon Nanotube ◽

Processing Unit ◽

Functionalized Graphene ◽

Multiwalled Carbon

Polymer composites with high thermal conductivity have a great potential for applications in modern electronics due to their low cost, easy process, and stable physical and chemical properties. Nevertheless, most polymer composites commonly possess unsatisfactory thermal conductivity, primarily because of the high interfacial thermal resistance between inorganic fillers. Herein, we developed a novel method through silver functionalized graphene nanosheets (GNS) and multiwalled carbon nanotube (MWCNT) composites with excellent thermal properties to meet the requirements of thermal management. The effects of composites on interfacial structure and properties of the composites were identified, and the microstructures and properties of the composites were studied as a function of the volume fraction of fillers. An ultrahigh thermal conductivity of 12.3 W/mK for polymer matrix composites was obtained, which is an approximate enhancement of 69.1 times compared to the polyvinyl alcohol (PVA) matrix. Moreover, these composites showed more competitive thermal conductivities compared to untreated fillers/PVA composites applied to the desktop central processing unit, making these composites a high-performance alternative to be used for thermal management.

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