scholarly journals Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

2009 ◽  
Vol 1 (1-2) ◽  
pp. 31-39 ◽  
Author(s):  
N. Y. Rapoport ◽  
A. L. Efros ◽  
D. A. Christensen ◽  
A. M. Kennedy ◽  
K.-H. Nam
2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.


2006 ◽  
Vol 6 (6) ◽  
pp. 525-535 ◽  
Author(s):  
Kun Na ◽  
Vijay Sethuraman ◽  
You Han Bae ◽  
Vijay Sethuraman

2016 ◽  
Vol 509 (1-2) ◽  
pp. 208-218 ◽  
Author(s):  
Maria Filippousi ◽  
Stuart Turner ◽  
Karen Leus ◽  
Panoraia I. Siafaka ◽  
Eirini D. Tseligka ◽  
...  

2020 ◽  
Vol 114 ◽  
pp. 111025 ◽  
Author(s):  
Yu-Fon Chen ◽  
Ming-Wei Hsu ◽  
Yu-Chu Su ◽  
Ho-Min Chang ◽  
Chien-Hsiang Chang ◽  
...  

2015 ◽  
Vol 6 (11) ◽  
pp. 1997-2010 ◽  
Author(s):  
Bo Liu ◽  
Xiaofang Zhang ◽  
Ya Chen ◽  
Zhicheng Yao ◽  
Zhe Yang ◽  
...  

The PEG-polyester copolymers bearing disulfide groups were synthesized to serve as redox-responsive anticancer drug carriers with an enhanced efficacy.


2014 ◽  
Vol 16 (29) ◽  
pp. 15681-15691 ◽  
Author(s):  
Raina Thakur ◽  
Anupam Das ◽  
Chandan Adhikari ◽  
Anjan Chakraborty

The entrapment and photodynamics of an anticancer drug ellipticine in different bile salt aggregates have been investigated using fluorescence spectroscopy.


Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 12026-12033 ◽  
Author(s):  
C. Yang ◽  
J. Uertz ◽  
D. Yohan ◽  
B. D. Chithrani

A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.


Author(s):  
R. Ansari ◽  
E. Kazemi ◽  
E. Mahmoudinezhad ◽  
F. Sadeghi

Cisplatin is one of the most widely prescribed chemotherapy drugs to treat different types of cancers. However, this anticancer drug has a number of side effects such as kidney and nerve damages, anaphylactic reactions, hearing loss, nausea, and vomiting that strongly restrict its function. In the present study, single-walled carbon nanotubes (SWCNTs) are used as protective drug carriers which can decrease these severe side effects to some extent. Using the hybrid discrete-continuum model in conjunction with Lennard-Jones potential, new semi-analytical expressions in terms of single integrals are given to evaluate van der Waals (vdW) potential energy and interaction force between an offset cisplatin and a SWCNT. In addition, molecular dynamics (MD) simulations are conducted to validate the results of such a hybrid approach. The preferred location and orientation of cisplatin while entering SWCNTs are determined. It is shown that the equilibrium condition of the drug may be affected by the radius of nanotube, the orientation of cisplatin, and the distance between the central molecule of the drug (Pt) and the left end of nanotube. Furthermore, the influence of equilibrium condition on the distributions of vdW interactions is investigated.


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