Circadian preference and sleep quality in healthy controls and psychiatric inpatients with major depressive disorder – An actigraphy study incorporating morning and evening mood assessments

AbstractMental health issues, including major depressive disorder, which can lead to suicidal behavior, are considered by the World Health Organization as a major threat to global health. Alterations in neurotransmitter signaling, e.g., serotonin and glutamate, or inflammatory response have been linked to both MDD and suicide. Phosphodiesterase 8A (PDE8A) gene expression is significantly decreased in the temporal cortex of major depressive disorder (MDD) patients. PDE8A specifically hydrolyzes adenosine 3′,5′-cyclic monophosphate (cAMP), which is a key second messenger involved in inflammation, cognition, and chronic antidepressant treatment. Moreover, alterations of RNA editing in PDE8A mRNA has been described in the brain of depressed suicide decedents. Here, we investigated PDE8A A-to-I RNA editing-related modifications in whole blood of depressed patients and suicide attempters compared to age-matched and sex-matched healthy controls. We report significant alterations of RNA editing of PDE8A in the blood of depressed patients and suicide attempters with major depression, for which the suicide attempt took place during the last month before sample collection. The reported RNA editing modifications in whole blood were similar to the changes observed in the brain of suicide decedents. Furthermore, analysis and combinations of different edited isoforms allowed us to discriminate between suicide attempters and control groups. Altogether, our results identify PDE8A as an immune response-related marker whose RNA editing modifications translate from brain to blood, suggesting that monitoring RNA editing in PDE8A in blood samples could help to evaluate depressive state and suicide risk.

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1H MRS Measurement of Cortical GABA and Glutamate in Primary Insomnia and Major Depressive Disorder: Relationship to Sleep Quality and Depression Severity

Journal of Affective Disorders ◽

10.1016/j.jad.2020.05.026 ◽

2020 ◽

Vol 274 ◽

pp. 624-631

Author(s):

Kathleen L. Benson ◽

Ryan Bottary ◽

Laura Schoerning ◽

Lee Baer ◽

Atilla Gonenc ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Sleep Quality ◽

Primary Insomnia ◽

Depression Severity ◽

Major Depressive ◽

1H Mrs

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P.2.110 Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls

European Neuropsychopharmacology ◽

10.1016/s0924-977x(05)80899-5 ◽

2005 ◽

Vol 15 ◽

pp. S439-S440

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Healthy Controls ◽

Major Depressive

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Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

Psychological Medicine ◽

10.1017/s0033291720000938 ◽

2020 ◽

pp. 1-10

Author(s):

V. H. Dam ◽

D. S. Stenbæk ◽

K. Köhler-Forsberg ◽

C. Ip ◽

B. Ozenne ◽

...

Keyword(s):

Working Memory ◽

Major Depressive Disorder ◽

Reaction Time ◽

Depressive Disorder ◽

Healthy Controls ◽

Cognitive Profiles ◽

Depression Severity ◽

Major Depressive ◽

Depressed Patients ◽

Cognitive Disturbances

Abstract Background Cognitive disturbances are common and disabling features of major depressive disorder (MDD). Previous studies provide limited insight into the co-occurrence of hot (emotion-dependent) and cold (emotion-independent) cognitive disturbances in MDD. Therefore, we here map both hot and cold cognition in depressed patients compared to healthy individuals. Methods We collected neuropsychological data from 92 antidepressant-free MDD patients and 103 healthy controls. All participants completed a comprehensive neuropsychological test battery assessing hot cognition including emotion processing, affective verbal memory and social cognition as well as cold cognition including verbal and working memory and reaction time. Results The depressed patients showed small to moderate negative affective biases on emotion processing outcomes, moderate increases in ratings of guilt and shame and moderate deficits in verbal and working memory as well as moderately slowed reaction time compared to healthy controls. We observed no correlations between individual cognitive tasks and depression severity in the depressed patients. Lastly, an exploratory cluster analysis suggested the presence of three cognitive profiles in MDD: one characterised predominantly by disturbed hot cognitive functions, one characterised predominantly by disturbed cold cognitive functions and one characterised by global impairment across all cognitive domains. Notably, the three cognitive profiles differed in depression severity. Conclusion We identified a pattern of small to moderate disturbances in both hot and cold cognition in MDD. While none of the individual cognitive outcomes mapped onto depression severity, cognitive profile clusters did. Overall cognition-based stratification tools may be useful in precision medicine approaches to MDD.

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Changes in sleep predict changes in depressive symptoms in depressed subjects receiving vortioxetine: An open-label clinical trial

Journal of Psychopharmacology ◽

10.1177/0269881119874485 ◽

2019 ◽

Vol 33 (11) ◽

pp. 1388-1394 ◽

Cited By ~ 3

Author(s):

Bing Cao ◽

Caroline Park ◽

Joshua D Rosenblat ◽

Yan Chen ◽

Michelle Iacobucci ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Sleep Quality ◽

Epworth Sleepiness Scale ◽

Quality Index ◽

Pittsburgh Sleep Quality Index ◽

Severity Index ◽

Major Depressive ◽

Insomnia Severity Index ◽

Insomnia Severity

Background Sleep disturbances are frequently reported in patients with major depressive disorder. We aimed to investigate the effects of vortioxetine on sleep quality and association between changes in sleep and treatment response. Methods: This study is a post-hoc analysis of a clinical trial that sought to evaluate the sensitivity to cognitive change of THINC-integrated tool in patients with major depressive disorder. In total, 92 patients (aged 18 to 65) meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe major depressive disorder and 54 healthy controls were included. All patients received open-label vortioxetine (10–20 mg/day, flexibly dosed) for 8 weeks. Herein, the primary outcomes of interest were changes in sleep, as measured by the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, between weeks 0, 2, and 8. The association between changes in sleep and depressive symptom severity was secondarily assessed. Results: We observed that sleep, as indicated by scores of Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, was significantly poorer in patients with major depressive disorder compared to healthy controls at weeks 0, 2, and 8 ( p < 0.05). Among patients with major depressive disorder, we observed significant improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index between weeks 0 and 8 ( p < 0.05). We observed a significant association between improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Insomnia Severity Index and improvement of depressive symptoms. Conclusion: Improvement of depressive symptoms in major depressive disorder patients treated with vortioxetine was associated with significant improvements in sleep. Furthermore, improvements in sleep were predictive of antidepressant response and were linearly correlated with improvement in overall depressive symptom severity.

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Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

10.21203/rs.3.rs-37400/v3 ◽

2020 ◽

Author(s):

Kuk-In Jang ◽

Chany Lee ◽

Sangmin Lee ◽

Seung Huh ◽

Jeong-Ho Chae

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Left Hemisphere ◽

Rating Scales ◽

Healthy Controls ◽

Major Depressive ◽

Alpha Asymmetry ◽

Alpha Frequency ◽

Frontal Alpha Asymmetry ◽

The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

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