Blood Pressure Level and Relation to other Cardiovascular Risk Factors in Male Hypertensive Patients without Clinical Evidence of Ischemic Heart Disease

Abstract Ischemic heart disease is underdiagnosed in women due to atypical symptomatology as well as to the lower specificity of several paraclinical tests, such as exercise stress testing. The aim of the study was to ascertain whether the Duke treadmill score (DTS) could be an efficient parameter in the diagnosis of ischemic heart disease in women. Material and method. 105 patients were enrolled in the study, 45.71% women with average age ranged between 20 and 70 years, investigated in the Rehabilitation Hospital, Cardiology-Departament, Cluj-Napoca, Romania. All the patients were clinically assessed as concerns the presence of cardiovascular risk factors, and they underwent electrocardiographic, echocardiographic and treadmill stress tests. DST was calculated according to the formula: exercise time – 5 x (ST deviation expressed in mm–4 x Angina Index). Results. DTS was lower in women as compared to men: 2.54±5.36 vs. 6±4.69, p=0.0006. 54.28% of the patients were ranged with a low DTS risk category, whereas 45.71% belonged to a moderate and high risk category. DTS was significantly lower in women than in men with high blood pressure (2.03±4.8 vs. 5.8±4.28), hypercholesterolemia (1.14±4.51 vs. 6.24±4.13), diabetes mellitus (1.83 ± 3.73 vs. 6.13±4.8), and obesity (2.42±5.35 vs. 5.81±4.64). By analyzing the presence of cardiovascular risk factors only in women, we noticed that only those with high blood pressure (2.03±4.89 vs. 8.13 ±7.85) and hypercholesterolemia (2.31±4.76 vs. 3.89±5.95) had a statistically significant low DTS (p<0.05). In conclusion, our research, which showed differences in DTS between women and men, raises concerns about the early diagnosis of ischemic heart disease in women.

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The prevalence and associated cardiovascular risk factors in resistant hypertensive subjects in Eastern India

Asian Journal of Medical Sciences ◽

10.3126/ajms.v5i4.9737 ◽

2014 ◽

Vol 5 (4) ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Pijush Kanti Mandal ◽

Arpan Kumar Day ◽

Subhraprakash Pramanik ◽

Shovan Kumar Das ◽

Sumit Khotick ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Heart Disease ◽

Cardiovascular Risk ◽

Ischemic Heart Disease ◽

Cardiovascular Risk Factors ◽

Resistant Hypertension ◽

P Value ◽

Hypertensive Patients ◽

Co Morbidity

Background: To study the prevalence and associated cardiovascular risk factors of ‘Resistant’ hypertension (RHT) in hypertensive patients of India.Methods: A descriptive cross-sectional observational study was carried out among 300 hypertensive patients attending ‘Hypertension Clinic’ and providing informed written consent from October 2013 to December 2013 at Burdwan Medical College and hospital, Burdwan, West Bengal in India. A pre-tested interviewer-administered questionnaire was used for data collection. Results: The prevalence of Resistant hypertension was 23.33% among all hypertensives. The patients with Resistant hypertension were significantly associated with older age groups (>55 years) (77.1% vs. 38.3%, p value <0.001, OR 5.446, 95% CI 2.935 and 10.104), Obesity (BMI > 27.5 kg/m2) (67.1% vs. 45.7%, p value 0.002, OR 2.433, 95% CI 1.387 and 4.268), Diabetes mellitus (72.9% vs. 45.2%, p value <0.001, OR 3.252, 95% CI 1.808 and 5.851), Prolonged hypertension (>10 years; 74.3% vs. 43.9%, p value <0.001, OR 3.690, 95% CI 2.033 and 6.696) and co-morbidity like Ischemic Heart Disease (60% vs. 44.8%, p value 0.026, OR 1.850, 95% CI 1.073 and 3.187) as risk factors as compared to patients with non-resistant hypertension. Conclusions: Nearly one fourth of the hypertensive persons were suffering from Resistant hypertension, which was significantly associated with the presence of older age, obesity, diabetes mellitus, longer duration of hypertension and co-morbidity like Ischemic Heart Disease as risk factors. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9737 Asian Journal of Medical Sciences 2014 Vol.5(4); 1-5

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Evaluation of Ischemic Heart Disease Factors in Hemophilia Patients in Khorramabad

Cardiovascular & Haematological Disorders - Drug Targets ◽

10.2174/1871529x20666201130105100 ◽

2020 ◽

Vol 20 ◽

Author(s):

Alireza Nezami ◽

Fariba Tarhani ◽

Sina Elahi

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Heart Disease ◽

Cardiovascular Risk ◽

Ischemic Heart Disease ◽

Cardiovascular Risk Factors ◽

Cardiovascular Death ◽

Ischemic Heart ◽

Cross Sectional ◽

Risk Predictor

Background: Evaluation of risk factors associated with coronary artery disease and cardiac health in hemophilia patients is necessary to prevent the onset of ischemic heart disease. In this study, we evaluated the cardiovascular status of hemophilic patients in Lorestan province for the early onset of ischemic heart disease. Methods: In this cross-sectional descriptive study, a total of 80 patients presenting severe hemophilia, the detailed questionnaire-based investigation was conducted to analyze the prevalence of cardiovascular risk factors in severe hemophilic patients. In patients with hemophilia, body mass index (BMI), blood pressure, diabetes, LDL, cholesterol and HDL, the risk of cardiovascular death was estimated using a predictive risk predictor algorithm of Europe SCORE. Results: The mean age of the patients was 25 years where all the patients were non-diabetic. Echocardiography did not show any wall motion abnormality and changes in the T wave and dysrhythmia was also not seen by ECG. 7 patients had high blood pressure, 11 had abnormal HDL, and 1 had abnormal LDL. In this study, serum LDL and HDL levels were not significantly correlated with age and BMI. Conversely, age and BMI were significantly associated with hypertension. Hypertension was observed in people over the age of 25 years and in overweighed individuals.78.8% had normal BMI and 21.3% were overweighed. There was no significant correlation between serum LDL, serum HDL, and blood pressure and sex. The levels of abnormal LDL and HDL were higher in men than in women. Conclusion: ECG findings from our study did not report any significant cardiac abnormalities among hemophilic patients. Cardiovascular risk factors were not significantly correlated in these paitents.

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Early blood pressure level as a mark of familial aggregation of metabolic cardiovascular risk factors – the Rio de Janeiro Study

Journal of Hypertension ◽

10.1097/00004872-199816121-00006 ◽

1998 ◽

Vol 16 (Supplement) ◽

pp. 1885-1889 ◽

Cited By ~ 5

Author(s):

Maria E.C. Magalhães ◽

Roberto Pozzan ◽

Andréa A. Brandão ◽

Rita C.O. Cerqueira ◽

Ana L.S. Rousoulieres ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Rio De Janeiro ◽

Familial Aggregation ◽

Blood Pressure Level ◽

Pressure Level

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Within-visit blood pressure variability and cardiovascular risk factors in hypertensive patients with non-dialysis chronic kidney disease

Clinical and Experimental Hypertension ◽

10.1080/10641963.2017.1313850 ◽

2017 ◽

Vol 39 (7) ◽

pp. 665-671 ◽

Cited By ~ 1

Author(s):

Kengo Azushima ◽

Hiromichi Wakui ◽

Kazushi Uneda ◽

Sona Haku ◽

Ryu Kobayashi ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Chronic Kidney Disease ◽

Cardiovascular Risk ◽

Kidney Disease ◽

Cardiovascular Risk Factors ◽

Blood Pressure Variability ◽

Hypertensive Patients

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Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s14063 ◽

2010 ◽

pp. 387 ◽

Cited By ~ 9

Author(s):

JOSE LUIS IZQUIERDO ◽

Arturo Martinez ◽

Elizabet Guzmán ◽

Pilar Lucas ◽

Gonzalez-Moro ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Cardiovascular Risk ◽

Ischemic Heart Disease ◽

Cardiovascular Risk Factors ◽

Ischemic Heart

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Influence of Conventional Cardiovascular Risk Factors and Lifestyle Characteristics on Cardiovascular Disease After Hematopoietic Cell Transplantation

Journal of Clinical Oncology ◽

10.1200/jco.2013.52.6582 ◽

2014 ◽

Vol 32 (3) ◽

pp. 191-198 ◽

Cited By ~ 53

Author(s):

Eric J. Chow ◽

K. Scott Baker ◽

Stephanie J. Lee ◽

Mary E.D. Flowers ◽

Kara L. Cushing-Haugen ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Disease ◽

Heart Disease ◽

Cardiovascular Risk ◽

Ischemic Heart Disease ◽

Cardiovascular Risk Factors ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Ischemic Heart

Purpose To determine the influence of modifiable lifestyle factors on the risk of cardiovascular disease after hematopoietic cell transplantation (HCT). Patients and Methods HCT survivors of ≥ 1 year treated from 1970 to 2010 (n = 3,833) were surveyed from 2010 to 2011 on current cardiovascular health and related lifestyle factors (smoking, diet, recreational physical activity). Responses (n = 2,362) were compared with those from a matched general population sample (National Health and Nutrition Examination Survey [NHANES]; n = 1,192). Results Compared with NHANES participants, HCT survivors (median age, 55.9 years; median 10.8 years since HCT; 71.3% allogeneic) had higher rates of cardiomyopathy (4.0% v 2.6%), stroke (4.8% v 3.3%), dyslipidemia (33.9% v 22.3%), and diabetes (14.3% v 11.7%; P < .05 for all comparisons). Prevalence of hypertension was similar (27.9% v 30.0%), and survivors were less likely to have ischemic heart disease (6.1% v 8.9%; P < .01). Among HCT survivors, hypertension, dyslipidemia, and diabetes were independent risk factors for ischemic heart disease and cardiomyopathy, and smoking was associated with ischemic heart disease and diabetes (odds ratios [ORs], 1.8 to 2.1; P = .02). Obesity was a risk factor for post-transplantation hypertension, dyslipidemia, and diabetes (ORs ≥ 2.0; P < .001). In contrast, lower fruit/vegetable intake was associated with greater risk of dyslipidemia and diabetes (ORs, 1.4 to 1.8; P ≤ .01), and lower physical activity level was associated with greater risk of hypertension and diabetes (ORs, 1.4 to 1.5; P < .05). Healthier lifestyle characteristics among HCT survivors attenuated risk of all cardiovascular conditions assessed. Conclusion Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT.

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P874Role of Genetic Polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease: an update

European Heart Journal ◽

10.1093/eurheartj/ehz747.0471 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

M Pucci ◽

P Severino ◽

A D'Amato ◽

L Netti ◽

R Scarpati ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Heart Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Ion Channels ◽

Ischemic Heart Disease ◽

Cardiovascular Risk Factors ◽

Genetic Polymorphisms ◽

Artery Disease

Abstract Background Ischemic heart disease (IHD) is classically associated with coronary artery disease (CAD) and conventional cardiovascular risk factors. However, IHD may exhibit in the absence of CAD, because of different pathophysiological mechanisms, such as the presence of specific genetic variants of ion channels, which act mainly in the microcirculation. Recently, we reported the correlation between some single nucleotide polymorphisms (SNPs) of ion channels genes and the presence of IHD, independently from the presence of conventional cardiovascular risk factors. The goal of this study is to confirm the results of the previous study on a bigger population and discover new SNPs of ion channels genes which may be associated with IHD. Methods A prospective, observational, single-center study was conducted on patients candidates for coronary angiography. Patients were divided in three groups: G1, coronary artery disease; G2, microvascular disfunction; G3, normal. Genetic polymorphisms relative to KCNJ11 encoding for the Kir6.1 and Kir6.2 subunits of K-ATP channels and KCNE1 encoding for the MinK subunit of IKs channels were analyzed. Results 603 consecutive patients (G1: 409; G2:76; G3:118) were enrolled. Genetic analysis for the three groups showed a statistically significant difference for the SNP S38G of KCNE1 (p=0.001) and for the variants rs5215, rs5218, rs5219 of KCNJ11 (p<0.0001), as well as comparing G1-G3 (S38G p=0.006; rs5215, rs5218 and rs5219 p<0.0001). Regarding G1-G2 we confirmed differences only for the variants rs5215 (p<0.0001), rs5218 (p=0.005) and rs5219 (p=0.024), while regarding G2-G3 we found differences for the variants S38G, rs5215 e rs5219 (p<0.0001). A multivariate analysis was performed and highlighted that the SNP rs5215_GG of KCNJ11 may represent an IHD independent protective factor (p<0.0001; OR: 0.036; 95.0% CI: 0.018–0.069). Conclusion These results confirm the importance of genetic susceptibility and the role of SNPs of ion channels genes in the determinism of IHD, independently from the conventional cardiovascular risk factors. Moreover, these results may represent a future perspective for a genic therapy for IHD.

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