A Nomogram Model to Predict Recurrence of Non-Muscle Invasive Bladder Urothelial Carcinoma After Resection Based on Clinical Parameters and Immunohistochemical Markers

2021 ◽  
pp. 1-9
Author(s):  
Jiangchuan Pi ◽  
Yongjiang Xiong ◽  
Chuan Liu ◽  
Juan Liao ◽  
Jiaji Liu ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Clinical Parameters ◽  
Immunohistochemical Markers ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive

scholarly journals Bioinformatic Identification of Potential Hub Genes in Muscle-Invasive Bladder Urothelial Carcinoma

2020 ◽  
Vol 29 ◽  
pp. 096368972096517
Author(s):  
Changgang Guo ◽  
Ting Shao ◽  
Dadong Wei ◽  
Chunsheng Li ◽  
Fengjun Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Overall Survival ◽  
Urothelial Carcinoma ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Hub Genes ◽  
Poor Overall Survival ◽  
Free Survival ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive

Despite aggressive treatment approaches, muscle-invasive bladder urothelial carcinoma (MIBC) patients still have a 50% chance of developing general incurable metastases. Therefore, there is an urgent need for candidate markers to enhance diagnosis and generate effective treatments for this disease. We evaluated four mRNA microarray datasets to find differences between non-MIBC (NMIBC) and MIBC tissues. Through a gene expression profile analysis via the Gene Expression Omnibus database, we identified 56 differentially expressed genes (DEGs). Enrichment analysis of gene ontology, Kyoto Encyclopedia of Genes and Genomes, and Reactome pathways revealed the interactions between these DEGs. Next, we established a protein-protein interaction network to determine the interrelationship between the DEGs and selected 10 hub genes accordingly. Bladder urothelial carcinoma (BLCA) patients with COL1A2, COL5A1, and COL5A2 alterations showed poor disease-free survival rates, while BLCA patients with COL1A1 and LUM alterations showed poor overall survival rates. Oncomine analysis of MIBC versus NMIBC tissues showed that COL1A1, COL5A2, COL1A2, and COL3A1 were consistently among the top 20 overexpressed genes in different studies. Using the TCGAportal, we noted that the high expression of each of the four genes led to shorter BLCA patient overall survival. It was evident that BLCA patients with an elevated high combined gene expression had significantly shorter overall survival and relapse-free survival than those with low combined gene expression using PROGgeneV2. Using Gene Expression Profiling Interactive Analysis, we noted that COL1A1, COL1A2, COL3A1, and COL5A2 were positively correlated with each other in BLCA. These genes are considered as clinically relevant genes, suggesting that they may play an important role in the carcinogenesis, development, invasion, and metastasis of MIBC. However, considering we adopted a bioinformatic approach, more research is crucial to confirm our results. Nonetheless, our findings may have important prospective clinical implementations.

Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma

2011 ◽  
Vol 18 (6) ◽  
pp. 432-438 ◽  
Author(s):  
Sentai Ding ◽  
Naidong Xing ◽  
Jiaju Lu ◽  
Hui Zhang ◽  
Koji Nishizawa ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive

scholarly journals Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

2020 ◽  
Author(s):  
Zijian Tian ◽  
Lingfeng Meng ◽  
Xin Wang ◽  
Tongxiang Diao ◽  
Maolin Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Urothelial Carcinoma ◽  
Young Patients ◽  
Multivariate Logistic Regression Analysis ◽  
Trend Test ◽  
Node Metastasis ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive ◽  
Effect Of Age

Abstract Background: The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph node positivity (LN+). This study aimed to evaluate the effect of age on LN+ in MIBC. Methods: We analyzed patients with stage T2–T4 bladder urothelial carcinoma who had not received preoperative radiotherapy, had at least one lymph node examined, and underwent cystectomy between 1998 and 2015. The Cochran–Armitage trend test and logistic univariate and multivariate analyses were used to evaluate the effect of age on LN+ in all T stages.Results: In total, 15624 patients with MIBC were identified, including 747 patients aged ≤50 years (4.78%), 2614 patients aged 50–59 years (16.73%), 4914 patients aged 60–69 years (31.45%), 5225 patients aged 70–79 years old (33.44%), and 2124 patients aged >80 years (13.59%). In T2–T4 staging, LN+ was negatively correlated with age. After adjustment for several covariates, multivariate logistic regression analysis revealed that age was an independent risk factor for LN+.Conclusions: Young patients with MIBC have a higher risk of lymph node metastasis. More active screening and treatment strategies should be considered for young patients with MIBC, whereas overtreatment should be avoided in elderly patients to prevent unnecessary complications.

scholarly journals Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

2020 ◽  
Author(s):  
Zijian Tian ◽  
Lingfeng Meng ◽  
Xin Wang ◽  
Tongxiang Diao ◽  
Maolin Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Urothelial Carcinoma ◽  
Young Patients ◽  
Multivariate Logistic Regression Analysis ◽  
Trend Test ◽  
Node Metastasis ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive ◽  
Effect Of Age

Abstract Background: The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph node positivity (LN+). This study aimed to evaluate the effect of age on LN+ in MIBC. Methods: We analyzed patients with stage T2–T4 bladder urothelial carcinoma who had not received preoperative radiotherapy, had at least one lymph node examined, and underwent cystectomy between 1998 and 2015. The Cochran-Armitage trend test and logistic univariate and multivariate analyses were used to evaluate the effect of age on LN+ in all T stages.Results: In total, 15624 patients with MIBC were identified, including 747 patients aged ≤50 years (4.78%), 2614 patients aged 50–59 years (16.73%), 4914 patients aged 60–69 years (31.45%), 5225 patients aged 70–79 years old (33.44%), and 2124 patients aged >80 years (13.59%). In T2–T4 staging, LN+ was negatively correlated with age. After adjustment for several covariates, multivariate logistic regression analysis revealed that age was an independent risk factor for LN+.Conclusions: In this large SEER analysis, young patients with MIBC were found to have a higher risk of lymph node metastasis. This finding is worthy of further study and may eventually affect treatment decisions in these patients.

scholarly journals Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zijian Tian ◽  
Lingfeng Meng ◽  
Xin Wang ◽  
Tongxiang Diao ◽  
Maolin Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Urothelial Carcinoma ◽  
Young Age ◽  
Node Metastasis ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive
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