scholarly journals Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models

2009 ◽  
Vol 21 (6) ◽  
pp. 512-518 ◽  
Author(s):  
R. A. Corley ◽  
K. R. Minard ◽  
S. Kabilan ◽  
D. R. Einstein ◽  
A. P. Kuprat ◽  
...  
Author(s):  
Yong He ◽  
Christi M. Terry ◽  
Scott A. Berceli ◽  
Alfred K. Cheung ◽  
Yan-Ting E. Shiu

An arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis in end-stage renal disease. However, 60% of AVFs fail to achieve sufficient lumen dilation to allow adequate blood flow for chronic dialysis [1]. Although hemodynamics is likely an important modulator of AVF maturation and remodeling, the AVF hemodynamic spatial distribution profiles and their relationship with AVF maturation and remodeling are unclear [2]. Based on data collected from magnetic resonance imaging (MRI) of an AVF and computational fluid dynamics (CFD) simulations, we developed a protocol for longitudinal (over time) and noninvasive monitoring of geometry and hemodynamics of human AVF.


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