Preparation and characterization of polylactic-co-glycolic acid/insulin nanoparticles encapsulated in methacrylate coated gelatin with sustained release for specific medical applications

AbstractPolymers derived from lactic and glycolic acid have achieved success in many medical applications and have been investigated as possible materials for degradable scaffolds required in tissue transplantation. Previous investigators have found significant differences in the behavior of cells cultured on chemically similar polyesters of this family but the mechanisms for these differences have remained unclear.In this study, we fabricated polylactic acid, polylactic-co-glycolic acid, and blend films by melt-processing. The bulk and surface properties of these films were characterized by GPC, DSC, WAXS, SEM, and contact angle. All films were smooth and amorphous and differed only in chemical composition. The films were assessed for their ability to sustain or promote hepatocyte attachment, growth, and function. Cells adhered to and exhibited similar morphology on all substrates. Cells decreased in number to 50–60% of the initial cell number but exhibited high retention of differentiated function on all of the polymer substrates over five days. Cell response was not statistically different on the different substrates indicating that chemical composition, in our range of polymer formulations, does not affect cell behavior.

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Synthesis and characterization of flurbiprofen axetil-loaded electrospun MgAl-LDHs/poly(lactic-co-glycolic acid) composite nanofibers

RSC Advances ◽

10.1039/c5ra11150a ◽

2015 ◽

Vol 5 (85) ◽

pp. 69423-69429 ◽

Cited By ~ 9

Author(s):

Chunyu Yang ◽

Tonghe Zhu ◽

Jihu Wang ◽

Sihao Chen ◽

Wenyao Li

Keyword(s):

Sustained Release ◽

Layered Double Hydroxides ◽

Glycolic Acid ◽

Composite Nanofibers ◽

Synthesis And Characterization ◽

Flurbiprofen Axetil ◽

Drug Sustained Release ◽

Model Drug ◽

Double Hydroxides

A model drug FA was intercalated into the interlayers of layered double hydroxides (LDHs) and the particles were dispersed into the PLGA nanofibers to form a carrier for drug sustained release.

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Preparation and characterization of copoly(dl-lactic/glycolic acid) microparticles for sustained release of thyrotropin releasing hormone by double nozzle spray drying method

Journal of Controlled Release ◽

10.1016/0168-3659(94)90227-5 ◽

1994 ◽

Vol 32 (1) ◽

pp. 79-85 ◽

Cited By ~ 16

Author(s):

Takada Shigeyuki ◽

Uda Yoshiaki ◽

Toguchi Hajime ◽

Ogawa Yasuaki

Keyword(s):

Sustained Release ◽

Spray Drying ◽

Glycolic Acid ◽

Thyrotropin Releasing Hormone ◽

Drying Method ◽

Releasing Hormone

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Formulation and characterization of ibuprofen sustained release tablets by solid dispersion technique

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2019.10.4.p64-75 ◽

2019 ◽

Vol 10 (4) ◽

Author(s):

MANJU S. ◽

C.RUBINA REICHAL Dr.

Keyword(s):

Sustained Release ◽

Solid Dispersion ◽

Sustained Release Tablets ◽

Dispersion Technique

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Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.101222 ◽

2019 ◽

Vol 53 ◽

pp. 101222 ◽

Cited By ~ 2

Author(s):

Zora Ćetković ◽

Sandra Cvijić ◽

Dragana Vasiljević

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Systems ◽

Delivery Systems

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Preparation and characterization of a sustained-release bio-preservative based on β-cyclodextrin encapsulated eugenol

Food Bioscience ◽

10.1016/j.fbio.2021.101192 ◽

2021 ◽

pp. 101192

Author(s):

Chan Bai ◽

Ping Xu ◽

Wenyuan Qi ◽

Qiulian Kong ◽

Juguang Wang ◽

...

Keyword(s):

Sustained Release

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Characterization of Intrinsically Radiolabeled Poly(lactic-co-glycolic acid) Nanoparticles for ex Vivo Autologous Cell Labeling and in Vivo Tracking

Bioconjugate Chemistry ◽

10.1021/acs.bioconjchem.1c00271 ◽

2021 ◽

Author(s):

Massis Krekorian ◽

Gerwin G. W. Sandker ◽

Kimberley R. G. Cortenbach ◽

Oya Tagit ◽

N. Koen van Riessen ◽

...

Keyword(s):

Glycolic Acid ◽

Ex Vivo ◽

Cell Labeling ◽

Autologous Cell

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Development and characterization of electrospun curcumin-loaded antimicrobial nanofibrous membranes

Textile Research Journal ◽

10.1177/0040517520925514 ◽

2020 ◽

pp. 004051752092551

Author(s):

Javeed A Awan ◽

Saif Ur Rehman ◽

Muhammad Kashif Bangash ◽

Fiaz Hussain ◽

Jean-Noël Jaubert

Keyword(s):

Biological Activities ◽

Research Work ◽

Medical Applications ◽

Electrospinning Technique ◽

Naturally Occurring ◽

Wide Range ◽

Nanofibrous Membranes ◽

Antimicrobial Barrier ◽

Anti Hiv

Curcumin is a naturally occurring hydrophobic polyphenol compound. It exhibits a wide range of biological activities such as antibacterial, anti-inflammatory, anti-carcinogenic, antifungal, anti-HIV, and antimicrobial activity. In this research work, antimicrobial curcumin nanofibrous membranes are produce by an electrospinning technique using the Eudragit RS 100 (C19H34ClNO6) polymer solution enriched with curcumin. The morphology and chemistry of the membrane are analyzed using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Kirby Bauer disk diffusion tests are carried out to examine the antibacterial effectiveness of the membrane. Experimental results show that the nanofibers produced are of uniform thickness morphology and curcumin is successfully incorporated into the nanofibrous mat, while no chemical bonding was observed between curcumin and the polymer. The antimicrobial curcumin nanofibrous membranes can be effectively applied as antimicrobial barrier in a wide variety of medical applications such as wound healing, scaffolds, and tissue engineering.

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