Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome

OBJECTIVE: To evaluate adrenal and ovarian steroidogenesis before and after long-term treatment with metformin in women with polycystic ovary syndrome (PCOS). DESIGN AND METHODS: Twenty-four women with PCOS were evaluated before and after treatment (27+/-4 weeks) with metformin (1000 mg/day) using adrenocorticotrophin (ACTH), GnRH analogue and oral glucose tolerance (oGTT) tests. For statistical evaluation, ANOVA and Wilcoxon's test were used. RESULTS: In 58% of the women a significant improvement in menstrual cyclicity was observed. No significant change in basal steroid levels was found. After ACTH stimulation, a significant decrease in the activity of 3 beta-hydroxysteroid dehydrogenase in C(21) steroids (P<0.05) and in 17 beta-hydroxysteroid dehydrogenase (P<0.01) was observed, as was an increase in the activity of C17,20-lyase in the Delta(4) pathway (P<0.01). A significant growth in the dehydroepiandrosterone (DHEA)/DHEA-sulfate ratio (P<0.05) was detected. With regard to ovarian steroidogenesis, a significant decrease in the stimulated levels of testosterone (P<0.05), index of free testosterone (P<0.01), LH (P<0.05) and oestradiol (P<0.01), and an increase in the levels of 17-hydroxypregnenolone (P<0.05) were detected. In the indices of ovarian enzyme activities, we observed a significant decrease in 3 beta-hydroxysteroid dehydrogenase in C21 steroids (P<0.01), in C17,20-lyase in the Delta 5 pathway (P<0.01), in 17 beta-hydroxysteroid dehydrogenase (P<0.05) and in aromatase. In glucose metabolism, a tendency towards reduction in the homeostasis model assessment (HOMA)-R (for insulin resistance) and HOMA-F (for beta cell function) was detected. In addition, an increase in the levels of C peptide during oGTT was observed (P<0.01). CONCLUSIONS: Long-term metformin treatment reduced various steroid enzymatic activities both in the ovary and the adrenal glands, without apparent changes in basal steroid levels and in insulin sensitivity.

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Effectiveness of self help strategies (shs) for pcos on biochemical parameters among young adult girls

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2400 ◽

2020 ◽

Vol 11 (3) ◽

pp. 3034-3041

Author(s):

Tamilselvi S ◽

Nalini S J

Keyword(s):

Polycystic Ovary ◽

Free Testosterone ◽

Term Treatment ◽

Exogenous Hormone ◽

Ovary Syndrome ◽

Self Help ◽

Long Term Treatment ◽

A Charge ◽

Adult Roles

Polycystic ovary syndrome (PCOS) with the predominance of 5 to 7% among youthful grown-up is a main source of infertility and endocrine issue. Metabolic clutters, for example, increased levels of LH and FSH in these young ladies was normal and impacts soundness of the youthful grown-up with PCOS in long-term. Treatment of female infertility and other entanglements needs to have direct hormones and get exogenous hormone. In this investigation, levels of Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) and testosterone among young adults with PCOS were measured. The consequence of this investigation demonstrated that LH, FSH and Free testosterone hormone levels were altogether extraordinary in this disorder. The adjustments in the hormones show an intense effect on the character of the young people. It is a time of existence with explicit wellbeing and formative needs and rights to create information and aptitudes figure out how to oversee feelings and connections, and secure properties and capacities that will be significant for getting a charge out of the immature years and expecting adult roles. To identify the effectiveness of self help strategies in reducing PCOS symptoms.

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A long-term treatment with gonadotropin-releasing hormone agonist plus a low-dose oral contraceptive improves the recovery of the ovulatory function in patients with polycystic ovary syndrome

Fertility and Sterility ◽

10.1016/s0015-0282(97)80070-2 ◽

1997 ◽

Vol 67 (3) ◽

pp. 463-468 ◽

Cited By ~ 20

Author(s):

Alessandro D. Genazzani ◽

Felice Petraglia ◽

Cesare Battaglia ◽

Ombretta Gamba ◽

Annibale Volpe ◽

...

Keyword(s):

Low Dose ◽

Polycystic Ovary ◽

Term Treatment ◽

Gonadotropin Releasing Hormone ◽

Ovary Syndrome ◽

Gonadotropin Releasing Hormone Agonist ◽

Long Term Treatment ◽

Dose Oral ◽

Dose Oral Contraceptive

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Characterization of Reproductive, Metabolic, and Endocrine Features of Polycystic Ovary Syndrome in Female Hyperandrogenic Mouse Models

Endocrinology ◽

10.1210/en.2014-1196 ◽

2014 ◽

Vol 155 (8) ◽

pp. 3146-3159 ◽

Cited By ~ 114

Author(s):

A. S. L. Caldwell ◽

L. J. Middleton ◽

M. Jimenez ◽

R. Desai ◽

A. C. McMahon ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Reproductive Age ◽

Polycystic Ovaries ◽

Ovary Syndrome ◽

Increased Risk ◽

Long Term Treatment ◽

Adipocyte Hypertrophy

Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a range of reproductive, metabolic and endocrine defects including anovulation, infertility, hyperandrogenism, obesity, hyperinsulinism, and an increased risk of type 2 diabetes and cardiovascular disease. Hyperandrogenism is the most consistent feature of PCOS, but its etiology remains unknown, and ethical and logistic constraints limit definitive experimentation in humans to determine mechanisms involved. In this study, we provide the first comprehensive characterization of reproductive, endocrine, and metabolic PCOS traits in 4 distinct murine models of hyperandrogenism, comprising prenatal dihydrotestosterone (DHT, potent nonaromatizable androgen) treatment during days 16–18 of gestation, or long-term treatment (90 days from 21 days of age) with DHT, dehydroepiandrosterone (DHEA), or letrozole (aromatase inhibitor). Prenatal DHT-treated mature mice exhibited irregular estrous cycles, oligo-ovulation, reduced preantral follicle health, hepatic steatosis, and adipocyte hypertrophy, but lacked overall changes in body-fat composition. Long-term DHT treatment induced polycystic ovaries displaying unhealthy antral follicles (degenerate oocyte and/or > 10% pyknotic granulosa cells), as well as anovulation and acyclicity in mature (16-week-old) females. Long-term DHT also increased body and fat pad weights and induced adipocyte hypertrophy and hypercholesterolemia. Long-term letrozole-treated mice exhibited absent or irregular cycles, oligo-ovulation, polycystic ovaries containing hemorrhagic cysts atypical of PCOS, and displayed no metabolic features of PCOS. Long-term dehydroepiandrosterone treatment produced no PCOS features in mature mice. Our findings reveal that long-term DHT treatment replicated a breadth of ovarian, endocrine, and metabolic features of human PCOS and provides the best mouse model for experimental studies of PCOS pathogenesis.

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