Background:
Eucalyptus camaldulensis Dehnh abundantly found in Erbil, Iraq and commonly used as antispasmodic and antipyretic remedy for treating respiratory tract diseases. The present study aimed to evaluate the effectiveness of
E. camaldulensis in achieving glucose homeostasis through the inhibition of α-glucosidase enzyme using in-vitro model and
also determine the chemical composition of essential oil by gas chromatography mass spectroscopy (GC/MS).
Methods:
The chemical composition of E. camaldulensis essential oil by was determined by GC/MS and its antidiabetic activity was assessed through inhibition of α-glucosidase enzyme in in-vitro models.
Results:
The essential oil yielded 40chemical constituents amounting to 98.55%. The major constituents of essential oil of
E. camaldulensis leaf were 1,8-cineole (28.4%), isocaryophyllene oxide (8.4%), β-ocimene (7.9%), α-farnesene (7.9%),
globulol (7.3%), terpinen-4-ol (7.6%), isophytol (3.6%), viridiflorol (3.2%), p-cymen-3-ol (3.1%) and α-bisabolol (1.2%).
The essential oil of E. camaldulensis showed concentration dependent inhibition of α-glucosidase enzyme and the inhibition
range from 75.38±2.09 to 6.08±1.89% for concentration 100 to 3.125 µg/mL. The α-glucosidase inhibition of E. camaldulensis (IC50 value 16.7±2.61 µg/mL) was found almost comparable with standard drug acarbose (IC50 value 12.04±3.17
µg/mL).
Conclusion:
The result of this study concluded that E. camaldulensis essential oil having 1,8-cineole, isocaryophyllene oxide and β-ocimene as major constituents, the study findings also confirm the traditional claim of its use in the treatment of
diabetes mellitus.
Chemical Variability, Antifungal and Antioxidant Activity of Eucalyptus camaldulensis Essential Oil from Sardinia
