Synthesis of the novel crown and lariat ethers with integrated 1,2,3-triazole ring

Triazole ring is a quite important five-membered heterocycle with three nitrogen atoms, possesses aromaticity and is an electron rich system. Triazole derivatives have been frequently becoming clinical drugs or candidates for the treatment of various types of diseases. Synthesis of the novel of 3-Benztriazole-5-yl difluoromethyl-5-trifluoromethyl benztriazole compound (3). Synthesis and chara-cterization of two new benzotriazole nucleosides with good yields by silyation method.

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1,2,4-Triazoles as Important Antibacterial Agents

Pharmaceuticals ◽

10.3390/ph14030224 ◽

2021 ◽

Vol 14 (3) ◽

pp. 224

Author(s):

Małgorzata Strzelecka ◽

Piotr Świątek

Keyword(s):

Drug Resistance ◽

Antibacterial Activity ◽

Biological Activity ◽

Rational Design ◽

Antibacterial Agents ◽

Antimicrobial Agents ◽

Triazole Ring ◽

The Novel ◽

Global Spread ◽

Antibacterial Potential

The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of this heterocyclic core. This review is useful for further investigations on this scaffold to harness its optimum antibacterial potential. Moreover, rational design and development of the novel antibacterial agents incorporating 1,2,4-triazole can help in dealing with the escalating problems of microbial resistance.

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Environmental Stability of Poly(Vinyl Chloride) Modified by Schiff’s Base under Exposure to UV

Biointerface Research in Applied Chemistry ◽

10.33263/briac115.1346513473 ◽

2021 ◽

Vol 11 (5) ◽

pp. 13465-13473

Keyword(s):

Schiff Base ◽

Vinyl Chloride ◽

Copper Chloride ◽

Uv Light ◽

Triazole Ring ◽

Environmental Stability ◽

The Novel ◽

Schiff’S Base ◽

Poly Vinyl Chloride ◽

Uv Light Irradiation

Polymers are used in different applications that might be an issue for the environment. Thus, our strategy is to create a material that can be more sustainable and last longer in use. For this purpose, a new Schiff base was synthesized containing a triazole ring (L), which was introduced to a poly (vinyl chloride) (PVC) chain via substitution reaction. Copper chloride was then added to the previous compound to give the final product PVC-L-Cu. The films' resistivity to degradation under Ultraviolet (UV) light irradiation was investigated under accelerated conditions. Fourier-transform infrared (FTIR) spectroscopy, weight loss, and scanning electron microscopy (SEM) were used to follow the changes after exposure to UV light. The novel Schiff base enhanced the photostability of PVC polymer significantly in comparison to the pristine polymer.

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