New zinc(II), copper(II), nickel(II), and vanadium(IV) complexes containing disulfide ligand: Synthesis, spectroscopic studies and calf thymus DNA interaction investigation

2017 ◽  
Vol 192 (10) ◽  
pp. 1102-1109
Author(s):  
Bita Shafaatian ◽  
Atefeh Baharian
Keyword(s):  
Dna Interaction ◽  
Spectroscopic Studies ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Ligand Synthesis

Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions

2020 ◽  
pp. 318-332
Author(s):  
Nagaraj Karuppiah ◽  
◽  
Muthukumaran Pakkirisamy ◽  
Gunasekaran Gladwin ◽  
Keyword(s):  
Dna Interaction ◽  
Spectroscopic Studies ◽  
Calf Thymus Dna ◽  
Aliphatic Chain ◽  
Groove Binding ◽  
Base Pairs ◽  
Surfactant Complex ◽  
Calf Thymus ◽  
Frame Work ◽  
Ct Dna

The interaction of cis-[Co(phen)2(TA)2](ClO4)3, a cationic surfactant complex (phen = 1-10 phenanthroline, TA= Tetradecylamine), with calf thymus DNA has been studied by physici-chemical techniques. The spectroscopic studies together with cyclic voltammetry and viscosity experiments support that the surfactant-cobalt(III) complex binds to calf thymus DNA (CT DNA) by intercalation through the aliphatic chain present in the complex into the base pairs of DNA. The presence of phenanthroline ligand with larger -frame work may also enhance intercalation. Besides the effect of binding of surfactant cobalt(III) complex to DNA in presence of -cyclodextrin has also studied. In presence of -cyclodextrin the binding occur through surface and (or) groove binding. The complex was investigated as one of the potential

Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases

2017 ◽  
Vol 172 ◽  
pp. 129-138 ◽  
Author(s):  
Cleiton M. da Silva ◽  
Marina M. Silva ◽  
Fabiano S. Reis ◽  
Ana Lúcia T.G. Ruiz ◽  
João E. de Carvalho ◽  
...  
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Cancer Cell ◽  
Radical Scavenging ◽  
Dna Interaction ◽  
Free Radical Scavenging ◽  
Calf Thymus Dna ◽  
Calf Thymus

Spectroscopic studies on the interaction of alpha‐eleostearic acid with calf thymus DNA

2019 ◽  
Vol 66 (10) ◽  
pp. 1381-1388
Author(s):  
Yufeng Liu ◽  
Baixin Zhang ◽  
Xiaomei Chen ◽  
Zhian Guo ◽  
Yi Wang ◽  
...  
Keyword(s):  
Eleostearic Acid ◽  
Spectroscopic Studies ◽  
Calf Thymus Dna ◽  
Calf Thymus

scholarly journals Interaction of Calf Thymus DNA with the Ni(II) Complex of Sodium 1,4-Dihydroxy-9,10-Anthraquinone-2-Sulphonate: A Novel Method of Analysis Using Cyclic Voltammetry

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Partha Sarathi Guin ◽  
Piyal Das ◽  
Saurabh Das ◽  
Parikshit Chandra Mandal
Keyword(s):  
Cyclic Voltammetry ◽  
Metal Ion ◽  
Dna Interaction ◽  
Calf Thymus Dna ◽  
Reduction Peak ◽  
Curve Fit ◽  
Diffusion Controlled ◽  
Binding Data ◽  
Calf Thymus ◽  
Electron Reduction

Hydroxy-9,10-anthraquinones are cheaper alternatives to anthracycline drugs. They closely resemble anthracycline drugs both from a structural and functional viewpoint. Electrochemical behavior of the Ni(II) complex (Na2[Ni(NaLH)2Cl2]⋅2H2O) of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (NaLH2), analogue of the core unit of anthracycline anticancer drugs, was studied at physiological pH using cyclic voltammetry. The Ni(II) complex of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate undergoes diffusion-controlled one-electron reduction that enables performing an electrochemical study on the interaction of the complex with calf thymus DNA. The complex was titrated with increasing concentrations of DNA, and the reduction peak for the unbound complex helped in evaluating binding parameters. Analysis of binding data using nonlinear curve fit in a cyclic voltammetry experiment is the first such attempt. The paper evaluates site size of interaction that also serves as a means to determine stoichiometry of complex formation, between a metal ion and ligand from a DNA interaction study, probably a first of its kind.

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