Possible signaling cascades involved in attenuation of alloxan-induced oxidative stress and hyperglycemia in mice by ethanolic extract of Syzygium jambolanum: Drug-DNA interaction with calf thymus DNA as target

Hydroxy-9,10-anthraquinones are cheaper alternatives to anthracycline drugs. They closely resemble anthracycline drugs both from a structural and functional viewpoint. Electrochemical behavior of the Ni(II) complex (Na2[Ni(NaLH)2Cl2]⋅2H2O) of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (NaLH2), analogue of the core unit of anthracycline anticancer drugs, was studied at physiological pH using cyclic voltammetry. The Ni(II) complex of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate undergoes diffusion-controlled one-electron reduction that enables performing an electrochemical study on the interaction of the complex with calf thymus DNA. The complex was titrated with increasing concentrations of DNA, and the reduction peak for the unbound complex helped in evaluating binding parameters. Analysis of binding data using nonlinear curve fit in a cyclic voltammetry experiment is the first such attempt. The paper evaluates site size of interaction that also serves as a means to determine stoichiometry of complex formation, between a metal ion and ligand from a DNA interaction study, probably a first of its kind.

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Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA

International Journal of Electrochemistry ◽

10.1155/2014/517371 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Partha Sarathi Guin ◽

Saurabh Das

Keyword(s):

Cyclic Voltammetry ◽

Anticancer Drug ◽

Dna Interaction ◽

Calf Thymus Dna ◽

Potential Range ◽

Spectroscopic Techniques ◽

Doxorubicin Hydrochloride ◽

Cathodic Peak ◽

Peak Current ◽

Calf Thymus

Electrochemical behavior of the anticancer drug doxorubicin hydrochloride was studied using cyclic voltammetry in aqueous medium using Hepes buffer (pH~7.4). At this pH, doxorubicin hydrochloride undergoes a reversible two-electron reduction withE1/2value −665±5 mV (versus Ag/AgCl, saturated KCl). Depending on scan rates, processes were either quasireversible (at low scan rates) or near perfect reversible (at high scan rates). This difference in behavior of doxorubicin hydrochloride with scan rate studied over the same potential range speaks of differences in electron transfer processes in doxorubicin hydrochloride. Attempt was made to identify and understand the species involved using simulation. The information obtained was used to study the interaction of doxorubicin hydrochloride with calf thymus DNA. Cathodic peak current gradually decreased as more calf thymus DNA was added. The decrease in cathodic peak current was used to estimate the interaction of the drug with calf thymus DNA. Nonlinear curve fit analysis was applied to evaluate the intrinsic binding constant and site size of interaction that was compared with previous results on doxorubicin hydrochloride-DNA interaction monitored by cyclic voltammetry or spectroscopic techniques.

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Thermodynamic Study of Rhodamine 123-Calf Thymus DNA Interaction: Determination of Calorimetric Enthalpy by Optical Melting Study

The Journal of Physical Chemistry B ◽

10.1021/jp509326r ◽

2014 ◽

Vol 118 (46) ◽

pp. 13151-13161 ◽

Cited By ~ 21

Author(s):

Abdulla Al Masum ◽

Maharudra Chakraborty ◽

Prateek Pandya ◽

Umesh Chandra Halder ◽

Md. Maidul Islam ◽

...

Keyword(s):

Dna Interaction ◽

Thermodynamic Study ◽

Calf Thymus Dna ◽

Rhodamine 123 ◽

Calf Thymus

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Synthesis, structure, electrochemical, DNA interaction and antimicrobial studies of fluorinated trans-dicationic pyridinium porphyrins

RSC Advances ◽

10.1039/c6ra09148b ◽

2016 ◽

Vol 6 (68) ◽

pp. 63271-63285 ◽

Cited By ~ 14

Author(s):

Jagadeesan Ramesh ◽

Subramaniam Sujatha ◽

Chellaiah Arunkumar

Keyword(s):

Dna Interaction ◽

Antimicrobial Activities ◽

Calf Thymus Dna ◽

Groove Binding ◽

Antimicrobial Studies ◽

Calf Thymus ◽

Artificial Nucleases

trans-Dicationic pyridinium porphyrins are superior artificial nucleases compared to their non-fluorinated analogues and bind with calf thymus DNA by outside groove binding with or without self-stacking, also show significant antimicrobial activities.

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Influence of Ionic Liquids on Thermodynamics of Small Molecule–DNA Interaction: The Binding of Ethidium Bromide to Calf Thymus DNA

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.5b11823 ◽

2016 ◽

Vol 120 (10) ◽

pp. 2691-2700 ◽

Cited By ~ 17

Author(s):

Arpit Mishra ◽

Mary Krishna Ekka ◽

Souvik Maiti

Keyword(s):

Ionic Liquids ◽

Ethidium Bromide ◽

Small Molecule ◽

Dna Interaction ◽

Calf Thymus Dna ◽

Calf Thymus

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New zinc(II), copper(II), nickel(II), and vanadium(IV) complexes containing disulfide ligand: Synthesis, spectroscopic studies and calf thymus DNA interaction investigation

Phosphorus Sulfur and Silicon and the Related Elements ◽

10.1080/10426507.2017.1331232 ◽

2017 ◽

Vol 192 (10) ◽

pp. 1102-1109

Author(s):

Bita Shafaatian ◽

Atefeh Baharian

Keyword(s):

Dna Interaction ◽

Spectroscopic Studies ◽

Calf Thymus Dna ◽

Calf Thymus ◽

Ligand Synthesis

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Cholinergic drugs bind at minor groove and reverse induced oxidative stress of calf thymus DNA: A new perspective towards an unexplored therapeutic efficacy

New Journal of Chemistry ◽

10.1039/d1nj01911b ◽

2021 ◽

Author(s):

Prayasee Baruah ◽

Pynskhemborlang Tep Phanrang ◽

Ibemhanbi Konthoujam ◽

Kripamoy Aguan ◽

Sivaprasad Mitra

Keyword(s):

Oxidative Stress ◽

Therapeutic Efficacy ◽

Deoxyribonucleic Acid ◽

Minor Groove ◽

Calf Thymus Dna ◽

Cholinergic Drugs ◽

Calf Thymus ◽

Life Threatening ◽

Dna Backbone ◽

New Perspective

Conformational alterations in the structure of deoxyribonucleic acid (DNA) due to oxidative stress in the DNA backbone are known to be at the root of many life-threatening diseases. Clear comprehension...

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