Anti-proliferative and Pro-apoptotic Effects ofCaesalpinia bonducExtract and its Fractions in Estrogen-Sensitive Human Breast Adenocarcinoma Cell Line

2013 ◽  
Vol 19 (2) ◽  
pp. 159-167 ◽  
Author(s):  
Abraham Ubhenin ◽  
Augustine Uwakwe ◽  
A. Falodun ◽  
N. Engel ◽  
Francis Onwuka ◽  
...  
2017 ◽  
Vol 88 ◽  
pp. 34-42 ◽  
Author(s):  
Mansoor Aletaha ◽  
Behzad Mansoori ◽  
Ali Mohammadi ◽  
Mehdi Fazeli ◽  
Behzad Baradaran

2002 ◽  
Vol 173 (1) ◽  
pp. 161-167 ◽  
Author(s):  
C Gil-Puig ◽  
M Blanco ◽  
T Garcia-Caballero ◽  
C Segura ◽  
R Perez-Fernandez

GH expression in mammary tumors has been related to the increase and spreading of cell proliferation. Using the MCF-7 human breast adenocarcinoma cell line, it has been demonstrated that autocrine GH-stimulated mammary carcinoma cell proliferation decreased the apoptosis rate and enhanced cell spreading. Surprisingly, no data are available about the presence of Pit-1 (the main pituitary regulator of GH) or GH expression in this cell line. Using RT-PCR, Western blot and immunohistochemistry, we have demonstrated the presence of both mRNA coding Pit-1 and GH as well as Pit-1 and GH protein in the MCF-7 cell line. These data could imply that Pit-1 may be an adequate target to inhibit breast cell proliferation.


Fitoterapia ◽  
2004 ◽  
Vol 75 (3-4) ◽  
pp. 375-377 ◽  
Author(s):  
Primchanien Moongkarndi ◽  
Nuttavut Kosem ◽  
Omboon Luanratana ◽  
Suna Jongsomboonkusol ◽  
Narongchai Pongpan

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