A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates

Background: The aim of this study was to evaluate clinico-pathologicalparameters and the status of argyrophilic nucleolar organizer regions stain in various histologicalgrades of oral squamous cell carcinoma. Materials and Methods: A cross sectional studywas conducted on fifty cases of oral squamous cell carcinoma. The specimen were collectedfrom the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosinstain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore. Results:Bidi smoking is associated with oral squamous cell carcinoma. The AgNOR (mAgNOR andpAgNOR) status was significantly low in well differentiated and moderately differentiatedcompared to poorly differentiated oral squamous cell carcinoma (p =0.001). AgNOR size inpoorly differentiated was significantly higher than the AgNOR size in well differentiated oralsquamous cell carcinoma. Similarly the distribution of AgNOR in moderately and poorlydifferentiated oral squamous cell carcinoma was significantly high. The AgNORs index wassignificantly high in poorly differentiated squamous cell carcinoma as compared to welldifferentiated and moderately differentiated squamous cell carcinoma. Conclusions: The useof AgNORs stain is easy, valid and reliable method to assess the histological grading of oralsquamous cell carcinoma and should be used to predict the prognosis of patients.

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A well differentiated oral squamous cell carcinoma involving the lateral border of tongue- A unique case report

International Dental Journal of Student Research ◽

10.18231/j.idjsr.2019.028 ◽

2020 ◽

Vol 7 (4) ◽

pp. 121-124

Author(s):

Sharmila M ◽

◽

Saravanan I ◽

Vivekanandan U ◽

Gonala Krishnan S ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Unique Case ◽

Lateral Border ◽

Well Differentiated

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Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v15i2.22707 ◽

2019 ◽

Vol 15 (2) ◽

pp. 125-127

Author(s):

Krishan Kumar Tyagi ◽

Megha Pradhan ◽

Rajbir Kaur Grewal ◽

Prabesh Sherchan ◽

KSA Pasha

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Human Papilloma Virus ◽

Cell Carcinoma ◽

Squamous Cell ◽

Control Group ◽

Papilloma Virus ◽

Mucosal Tissues ◽

Well Differentiated

Background: Head and neck malignancies include malignancies instigating in the oral cavity, the orophar-ynx, the hypopharynx and the larynx. We planned the present study to assess the role of human papilloma virus (HPV) in patients with oral squamous cell carcinoma (OSCC). Methods: The present study included assessment of role of human papilloma virus in patients with oral squamous cell carcinoma. A total of 50 histopathologic proven cases of well differentiated OSCC were included in the present study. A total of 50 healthy oral mucosal tissues (controls) were also included in the present study. The controls were obtained while surgical removing the impacted teeth. DNA was obtained from the tissue sections and underwent Polymerization chain reaction for identification of HPV 16/18. All the results were summarized in Microsoft excel sheet and were analyzed by SPSS software. Results: HPV was absent in all the cases of control group, whereas among the OSCC group, the HPV was detected in 46 percent of the cases. In the remaining 54 per-cent of the cases of the OSCC group, HPV was absent. Significant results were obtained while comparing the presence of HPV in between the OSCC group and the control group. Conclusions: HPV was present in sig-nificant number of OSCC cases. Therefore; HPV might play a contributing role in the etio-pathogenesis of OSCC.

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