ORAL SQUAMOUS CELL CARCINOMA

Background: The aim of this study was to evaluate clinico-pathologicalparameters and the status of argyrophilic nucleolar organizer regions stain in various histologicalgrades of oral squamous cell carcinoma. Materials and Methods: A cross sectional studywas conducted on fifty cases of oral squamous cell carcinoma. The specimen were collectedfrom the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosinstain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore. Results:Bidi smoking is associated with oral squamous cell carcinoma. The AgNOR (mAgNOR andpAgNOR) status was significantly low in well differentiated and moderately differentiatedcompared to poorly differentiated oral squamous cell carcinoma (p =0.001). AgNOR size inpoorly differentiated was significantly higher than the AgNOR size in well differentiated oralsquamous cell carcinoma. Similarly the distribution of AgNOR in moderately and poorlydifferentiated oral squamous cell carcinoma was significantly high. The AgNORs index wassignificantly high in poorly differentiated squamous cell carcinoma as compared to welldifferentiated and moderately differentiated squamous cell carcinoma. Conclusions: The useof AgNORs stain is easy, valid and reliable method to assess the histological grading of oralsquamous cell carcinoma and should be used to predict the prognosis of patients.

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Altered Coagulation Pattern in Different Histological Grades of Squamous Cell Carcinoma

Journal of Islamabad Medical & Dental College ◽

10.35787/jimdc.v9i2.281 ◽

2020 ◽

Vol 9 (2) ◽

pp. 123-128

Author(s):

Kiran Shaikh ◽

Ghulam Shah Nizamani ◽

Yar Muhammad Nizamani ◽

Naila Nizamani ◽

Amin Fahim ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Age Groups ◽

University Hospital ◽

High Rate ◽

Cross Sectional ◽

Coagulation Profile ◽

Poorly Differentiated ◽

Well Differentiated

Background: The incidence of squamous cell carcinoma has doubled in the last three decades associated with a high rate of morbidity and mortality. The incidence of bleeding and/or thrombosis in advanced stage cancer necessitates a need for research in blood coagulation abnormalities in malignancy. The objective of the present study was to determine the alteration in coagulation pattern among patients diagnosed with squamous cell carcinoma (SCC). Material and Methods: This cross-sectional study was conducted in Pathology department of Isra University Hospital, Hyderabad over a period of 06 months. A total of 126 samples were selected through non-probability convenient sampling. Both male and female patients of all age groups having SCC of skin, gastrointestinal and genital tract were included. The coagulation profile was analyzed by Sysmax CA 50 and Nycocard reader II. Data was entered into SPSS version 22.0 and results were analyzed. Results: The mean age of the patients with SCC in the present study was 55.5 ± 12 years with more male patients (n=81; 64.3%) as compared to females (n=45; 35.7%). Oral SCC was found to be the most common site of squamous cell carcinoma (43.7%). Majority of the patients had well differentiated SCC (42.1%) followed by moderately differentiated (40.5%) and poorly differentiated SCC (17.4%). The comparison of severity of SCC with coagulation profile revealed that PT (P=0.01), APTT (P=0.001), D-dimers (P=0.01 and TT (P=0.01) were significantly increased, whereas fibrinogen was significantly decreased (P=0.001). Conclusions: The histological differentiation of SCC (from well differentiated to poorly differentiated tumors) showed a highly significant association with different coagulation profile parameters like PT, APTT, BT, CT, D-dimer, TT, and fibrinogen levels.

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Correlation of increased numbers of tumor-infiltrating T regulatory, CD19 and CD8 T cells in well differentiated oral squamous cell carcinoma

InterAmerican Journal of Medicine and Health ◽

10.31005/iajmh.v1i1.25 ◽

2018 ◽

Vol 1 ◽

pp. e201801004

Author(s):

Victor Angelo MONTALLI ◽

Fabrício PASSADOR-SANTOS ◽

Andresa Borges SOARES ◽

Elizabeth F. MARTINEZ ◽

Denise B. R. RODRIGUES ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tumor Antigens ◽

Tumor Grade ◽

Inflammatory Cells ◽

Tissue Microarrays ◽

Poorly Differentiated ◽

Well Differentiated

Evidence from cancer patients suggests that increases in T-regulatory lymphocyte (Treg) activity may be associated with poor immune responses against tumor antigens, and contribute to immune dysfunction. Since there have been contradictory reports concerning the physiological roles of the Treg and inflammatory cells in the tumor microenvironment, the inflammatory cell influx was investigated for different malignancygrades of oral squamous cell carcinoma (OSCC). A total of 42 patients with OSCC were selected. Tumors were histologically graded as well, moderately, or poorly differentiated. Tissue microarrays were performed to immunohistochemically measure the expression of CD8, Foxp3, CD19, and IL-10. Significant statistical increases (p<0.05) were observed in the numbers of Foxp3+ and CD8+ inflammatory cells, as well as inIL-10 expression, in the well differentiated tumors, compared to the poorly differentiated tumors. No differences between the three different histological grades were observed in the numbers of CD19+ cells. The relationship between the tumor grade and Treg and CD8 cell recruitment in patients with OSCC underlined the fact that the immune system is deregulated as a consequence of the disease.

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Epidemiological study of oral squamous cell carcinoma: A hospital based study in Dhaka city

TAJ Journal of Teachers Association ◽

10.3329/taj.v28i2.39075 ◽

2018 ◽

Vol 28 (2) ◽

pp. 22-25

Author(s):

Md Abul Hossain ◽

Md Mahiuddin Ahmed ◽

AFM Shahidur Rahman ◽

Md Nasim Haider ◽

AKM Serajul Alam

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Dhaka City ◽

Cross Sectional ◽

Total Prevalence ◽

Level Hospital

Objective: To find out the prevalence of oral squamous cell carcinoma among the tertiary and specialized level hospital in Dhaka cityMaterials and methods: A cross sectional study was carried out in the department of Oral and Maxillofacial surgery of DDCH, NICRH, BSMMU and ShSMCH from january2009 to july 2010 .A total of 324 patient of histopatholgically proven cases of oscc were selected as a sample size. Both primary and secondary data were collected for the study. The prevalence OSCC were calculated by dividing the OSCC patient by total number of patient multiplying 100.Results: The total prevalence of OSCC 3.55% among the 4 tertiary and specialized level hospital in Dhaka city.Conclusion: The prevalence of OSCC among tertiary and specialized level hospital of Dhaka city was 3.55%.The rate is quite high. The prevalence of risk factor includes betel quit, smokeless tobacco, smoking and poor oral hygiene mas also high. The majority of the patient were present in advance stage of the diseases.TAJ 2015; 28(2): 22-25

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Penentuan Grading Tumor Ganas Oral Squamous Cell Carcinoma Berdasarkan Gambaran Histopatologi

Jurnal Biosains Pascasarjana ◽

10.20473/jbp.v17i1.2015.46-51 ◽

2015 ◽

Vol 17 (1) ◽

pp. 46

Author(s):

Theresia Indah Budhy

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Stage Iv ◽

Stage I ◽

Stage Iii ◽

Low Grade ◽

Poorly Differentiated ◽

Well Differentiated

AbstrakLatar Belakang: Sekitar 95% dari tumor ganas diklasifikassikan secara histologis sebagai Oral Squamous Cell Carcinoma (OSCC). Secara mikroskopis OSCC diklasifikasikan berdasarkan pada metode yang mempehitungkan penilaian subjektif, tingkat keratinisasi, pleomorfik nukleus dan seluler, dan aktivitas mitosis. Tingkatan tersebut meliputi well differentiated (grade I-II), moderately differentiated (grade III), dan poorly differentiated (grade IV). Well dan moderately differentiated dapat dikelompokkan sebagai low grade sedangkan poorly differentiated tumor sebagai high grade. Standar yang paling baik untuk menegakkan diagnosis OSCC adalah pemeriksaan histopatologis dan biopsi jaringan lesi tersebut. Tujuan: Penelitian ini bertujuan untuk menentukan grading tumor ganas OSCC berdasarkan gambaran histopatologi. Metode: Sampel terdiri dari 6 jenis OSCC kemudian dilakukan pembuatan sediaan jaringan tumor ganas OSCC kedalam blok paraffin dan dilakukan pengecatan menggunakan hematoxilin eosin (HE). Gambaran histopatologi dari keenam sampel diamati dibawah mikroskop cahaya dengan pembesaran 100x dan 400x. Hasil: Dari 6 kasus yang ditemukan satu terdiagnosa sebagai well differentiated (stage I), dua kasus terdiagnosa well differentiated(sstage II), dua kasus terdiagnosa moderately differentiated (stage III), dan poorly differentiated (stage IV). Kesimpulan: OSCC diklasifikasikan berdasarkan gambaran histopatologi kedalam well differentiated (stage I-II), moderately differentiated (stage III), dan poorly differentiated (stage IV)Kata Kunci : OSCC, well differentiated, moderately differentiated, poorly differentiated

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Iron deficiency and risk of oral squamous cell carcinoma

Pakistan BioMedical Journal ◽

10.52229/pbmj.v4i1.53 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Imrana Tanvir ◽

Rizwan Ullah Khan ◽

Amber Hassan ◽

Sami Ullah Mumtaz

Keyword(s):

Squamous Cell Carcinoma ◽

Iron Deficiency ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Young Patients ◽

Cross Sectional Study ◽

Cross Sectional ◽

Well Differentiated ◽

Age Range

Oral squamous cell carcinoma (OSCC) is a subset of head and neck squamous cell carcinoma caused by excessive substance abuse like alcohol, tobacco etc. Objectives: Aim of the present study was to evaluate the iron expression in different grades of OSCC and potential of iron staining as a prognostic marker and its importance as an essential nutrient in diet. Methods and Patients: It was a cross sectional study. A total of 40 oral biopsies were evaluated and the mean age of patients was 53.5 years with age range 23-80 years. 14 cases were well differentiated, 14 moderately differentiated and there were 12 poorly differentiated case. Iron staining was performed for all these cases. Results: Iron positivity was observed in 11 (27.5%) of OSCC patients with maximum iron positivity in well differentiated group (64.28%) of age range 20-40 years (70%). More patients had tongue as site of cancer. There was no genderwise difference in iron expression. Iron deficiency was associated with poor prognosis indicating iron as an important nutrient which can prevent OSCC if adequately present in our routine diet. Conclusions: Prevalence of iron positivity in young patients and initial stage of OSCC, indicates the protective effect of iron against oral squamous cell carcinoma

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Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

The Journal of Laryngology & Otology ◽

10.1017/s0022215112001995 ◽

2012 ◽

Vol 126 (11) ◽

pp. 1134-1137 ◽

Cited By ~ 5

Author(s):

T Nakashima ◽

R Yasumatsu ◽

M Masuda ◽

G L Clayman ◽

S Komune

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cathepsin L ◽

Prognostic Significance ◽

Metastatic Potential ◽

Poorly Differentiated ◽

Well Differentiated ◽

Immunohistochemical Studies

AbstractObjective:To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.Design:Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.Results:The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.Conclusion:Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.

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Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x19847359 ◽

2019 ◽

Vol 7 ◽

pp. 2050313X1984735 ◽

Cited By ~ 2

Author(s):

Catherine F Roy ◽

Simon F Roy ◽

Feras M Ghazawi ◽

Erica Patocskai ◽

Annie Bélisle ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hidradenitis Suppurativa ◽

Rare Complication ◽

Excisional Biopsy ◽

Necrosis Factor Alpha ◽

Spindle Cells ◽

Poorly Differentiated ◽

Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

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