Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy

2017 ◽  
Vol 39 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Wenni Li ◽  
Junlin Wang ◽  
Lina Ge ◽  
Jiehui Shan ◽  
Chunbing Zhang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Detection ◽  
Growth Arrest ◽  
Specific Protein ◽  
Noninvasive Biomarker

scholarly journals Urinary nephrin is earlier, more sensitive and specific marker of diabetic nephropathy than microalbuminuria

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Irena Kostovska ◽  
Tosheska Trajkovska ◽  
Sonja Topuzovska ◽  
Svetlana Cekovska ◽  
Goce Spasovski ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Detection ◽  
Cross Sectional Study ◽  
Specific Protein ◽  
Control Group ◽  
Photometric Method ◽  
Specific Marker ◽  
Cross Sectional ◽  
Potential Biomarker ◽  
Stage Renal Disease

Summary Background Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Progressive damage and decline in the number of podocytes often occur in the early stages of DN. Thus, nephrin as a podocyte-specific protein may be regarded as a potential biomarker of early detection of DN. The aim of this study is to determine whether urinary nephrin is an earlier marker in DN than microalbuminuria and to test the significance of urinary nephrin as a marker for early detection of DN. Methods Our cross-sectional study included 90 patients with type 2 diabetes mellitus (T2DM), 30 patients with diagnosed DN and 60 patients without diagnosed DN. As a control group, we used 30 healthy subjects. All patients with T2DM were classified into three subgroups according to urinary microalbumin/creatinine ratio (UMCR): normoalbuminuric, microalbuminuric and macroalbuminuric patients. Nephrin in urine was measured by immunoenzyme assay, microalbumin with turbidimetric and creatinine with the photometric method. In blood sera, we measured a few standard biochemical parameters. Results Nephrinuria was found to be present in 100% of patients with T2DM and macroalbuminuria, in 88% with microalbuminuria, as well as 82% of patients with T2DM and normoalbuminuria. A concentration of urinary nephrin was significantly increased in all groups of subjects with T2DM compared to the control group (p<0.05). Nephrinuria correlated statistically negative with eGFR (r=-0.54). ROC analysis showed that nephrin has a total predicted probability of 96% in patients with DN. Conclusions Urinary nephrin is earlier, more specific and sensitive marker than microalbumin in early detection of DN.

Urinary Beta-Thromboglobulin Correlates with Impairment of Renal Function in Patients with Diabetic Nephropathy

1986 ◽  
Vol 56 (02) ◽  
pp. 229-231 ◽  
Author(s):  
A H Hopper ◽  
H Tindall ◽  
J A Davies
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Microvascular Disease ◽  
Normal Subjects ◽  
Specific Protein ◽  
Creatinine Concentration ◽  
Β2 Microglobulin ◽  
Plasma Creatinine Concentration ◽  
Insulin Dependent ◽  
Indium 111

SummaryTBeta-thromboglobulin (βTG) is a platelet-specific protein and since its concentration in plasma rises when platelets are activated, it has been used as an indicator of platelet involvement in vascular disease. Since platelets might be involved in the pathogenesis of diabetic microvascular disease we measured urinary βTG in 20 insulin-dependent diabetics with nephropathy and compared the results with those from 20 normal subjects. Measurement of βTG in urine was undertaken to avoid errors induced by blood sampling and to gain information over a prolonged period using a single assay. Measurements were made of βTG, β2-microglobulin and total protein in urine collected for 24 h and creatinine and β2 microglobulin in plasma. Survival of indium-111-labelled platelets was measured in nine patients. Urinary PTG was significantly (p <0.02) increased in the 20 patients compared with 20 normal volunteers (median value 1.3 vs 0.8 μg/24 h). There was a strong correlation between urinary βTG excretion and plasma creatinine concentration (r = 0.8, p <0.0001) and plasma β2-microglobulin concentration (r = 0.9, p <0.0001). Urinary βTG concentration did not correlate with platelet survival. The results indicate that although urinary βTG is significantly increased in patients with diabetic nephropathy its concentration in urine correlates with indicators of glomerular filtration rather than with a test of platelet activation.

scholarly journals Interaction of influenza virus NS1 protein with growth arrest-specific protein 8

2009 ◽  
Vol 6 (1) ◽  
pp. 218 ◽  
Author(s):  
Lixia Zhao ◽  
Long Xu ◽  
Xiaowei Zhou ◽  
Qingyu Zhu ◽  
Zhixin Yang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Growth Arrest ◽  
Specific Protein ◽  
Ns1 Protein

Potential serum biomarkers for early detection of diabetic nephropathy

2018 ◽  
Vol 136 ◽  
pp. 150-158 ◽  
Author(s):  
Tarek Kamal Motawi ◽  
Nagwa Ibrahim Shehata ◽  
Mahmoud Mohamed ElNokeety ◽  
Yasmin Farid El-Emady
Keyword(s):  
Diabetic Nephropathy ◽  
Early Detection ◽  
Serum Biomarkers

354 Growth arrest-specific protein 6 (GAS6) promotes liver tissue repair after an acute toxic injury

2006 ◽  
Vol 44 ◽  
pp. S135 ◽  
Author(s):  
F. Lafdil ◽  
V. Deveaux ◽  
M.N. Chobert ◽  
A. Brouillet ◽  
E.S. Zafrani ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Tissue Repair ◽  
Growth Arrest ◽  
Specific Protein ◽  
Toxic Injury ◽  
Acute Toxic

Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy

2021 ◽  
pp. jim-2021-001785
Author(s):  
Rasha A Elkholy ◽  
Reham L Younis ◽  
Alzahraa A Allam ◽  
Rasha Youssef Hagag ◽  
Muhammad Tarek Abdel Ghafar
Keyword(s):  
Diabetic Nephropathy ◽  
Early Detection ◽  
Characteristic Curve ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Control Group ◽  
Diagnostic Efficacy ◽  
Significant Difference ◽  
Patients With Diabetes

This study aimed to assess the diagnostic value of serum and urinary netrin-1 in patients with type 2 diabetes mellitus (T2DM) at different stages of diabetic nephropathy (DN) and to compare its efficacy of estimation in serum with that in the urine. This study was carried out on 135 patients with T2DM and 45 healthy subjects. The patients with diabetes were divided according to urinary albumin creatinine ratio (UACR) into: T2DM with normoalbuminuria, incipient DN with microalbuminuria, and overt DN with macroalbuminuria groups. Serum and urinary levels of netrin-1 were measured by ELISA. The mean levels of serum and urinary netrin-1 were significantly higher in the microalbuminuric and macroalbuminuric patients with DN than those in the normoalbuminuric patients with T2DM, with the highest values detected in macroalbuminuric patients with DN. Urinary netrin-1 level was significantly higher in the normoalbuminuric T2DM group than control group, whereas no significant difference existed regarding serum netrin-1 level. In T2DM groups, the urinary and serum netrin-1 correlated with each other and were independently related to fasting blood glucose, UACR, and estimated glomerular filtration rate. Receiver operating characteristic curve analysis showed that the area under the curve of urinary netrin-1 was 0.916 which is significantly higher than that of serum netrin-1 (0.812) for the detection of incipient DN and reached 0.938 on coestimation of both urinary and serum netrin-1. In conclusion, netrin-1 is a potential diagnostic marker for early detection of DN with its estimation in urine has higher accuracy than that of serum.

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