Estimation of the Upper Confidence Limit on the Mean of Datasets with Count-Based Concentration Values

Author(s):  
William Brattin ◽  
Timothy Barry ◽  
Stiven Foster
1984 ◽  
Vol 107 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Gösta Enberg ◽  
Kerstin Hall

Abstract. A radioimmunoassay has been developed for IGF-II, using Sepharose-coupled antibodies. Porcine insulin, human insulin and human proinsulin showed no cross-reaction, whereas the cross-reaction for IGF-I was 10%. To minimize the influence of the binding protein(s), all serum samples were extracted with acid ethanol before assay. The mean serum level of immunoreactive IGF-II and 95% confidence limit in 46 healthy adults were 587 ng/ml and 354–974 ng/ml, respectively. In contrast to the declining levels of IGF-I with increasing age, no such age-dependent decrease was found for IGF-II levels between 20 to 70 years. No difference in IGF-II levels was found between patients with acromegaly and healthy adult controls. In cord serum and serum from adult patients with GH deficiency the levels were significantly lower (P < 0.001) compared to controls. In diabetic patients with uraemia the mean level and 95% confidence limit were 1222 ng/ml and 532–2808 ng/ml, respectively. Thus, significantly increased serum levels of immunoreactive IGF-II have only been found in serum from patients with uraemia. Whether this is due to an increased production of IGF-II, or secondary to other factors such as the binding protein(s), will require further investigation.


2019 ◽  
Vol 490 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Devansh Agarwal ◽  
Duncan R Lorimer ◽  
Anastasia Fialkov ◽  
Keith W Bannister ◽  
Ryan M Shannon ◽  
...  

ABSTRACT The rate of fast radio bursts (FRBs) in the direction of nearby galaxy clusters is expected to be higher than the mean cosmological rate if intrinsically faint FRBs are numerous. In this paper, we describe a targeted search for faint FRBs near the core of the Virgo Cluster using the Australian Square Kilometre Array Pathfinder telescope. During 300 h of observations, we discovered one burst, FRB 180417, with dispersion measure (DM) = 474.8 cm−3 pc. The FRB was promptly followed up by several radio telescopes for 27 h, but no repeat bursts were detected. An optical follow-up of FRB 180417 using the PROMPT5 telescope revealed no new sources down to an R-band magnitude of 20.1. We argue that FRB 180417 is likely behind the Virgo Cluster as the Galactic and intracluster DM contribution are small compared to the DM of the FRB, and there are no galaxies in the line of sight. The non-detection of FRBs from Virgo constrains the faint-end slope, α &lt; 1.52 (at 68 per cent confidence limit), and the minimum luminosity, Lmin ≳ 2 × 1040 erg s−1 (at 68 per cent confidence limit), of the FRB luminosity function assuming cosmic FRB rate of 104 FRBs per sky per day with flux above 1 Jy located out to redshift of 1. Further FRB surveys of galaxy clusters with high-sensitivity instruments will tighten the constraints on the faint end of the luminosity function and, thus, are strongly encouraged.


2010 ◽  
Vol 44-47 ◽  
pp. 3003-3010
Author(s):  
Shi Lian Xu ◽  
Rui Hong Wang ◽  
Ruo Qi Li ◽  
Ren Ping Xu

The brittle is crippling the application of bioceramic. The compound bioceramic is a new biomaterial being widely applied in medical treatments and its fracture toughness is an important mechanical behaviors. In this paper, we introduce the manufacturing method of the compound bioceramic and experiment facilities for its fracture toughness, investigate its probability distribution for the experimental data and conduct the test for fit. We conclude that the experimental data for the toughness fracture of the compound bioceramic obey the two-parameter Weibull distribution, introduce the analyzing method for the upper confidence limit curve and lower confidence limit curve and study the reliability and confidence level of the fracture toughness of the compound bioceramic.


2021 ◽  
Vol 2145 (1) ◽  
pp. 012049
Author(s):  
R Supakulopas

Abstract Archaeological dating is crucial in archaeology as it is a key to understand human history. However, traditional dating methods used by archaeologists such as potassium-argon dating and luminescence dating can provide ambiguous age results, e.g., argon loss during the dating returns young apparent ages. Therefore, I plan to establish an archaeomagnetic secular variation (ASV) curve to resolve this problem and use the ASV curve as an alternative tool to date archaeological artefacts. However, archaeomagnetic data in Thailand are absent from literature. Therefore, the ASV curve cannot be constructed from the archaeomagnetic data for this locality. To provide archaeomagnetic data to construct the ASV curve, the directions of the Earth’s magnetic field recorded in kiln walls from Ban Ko Noi (KN123, age 1,370 ± 100 A.D.), Si Satchanalai were measured. The mean declination and inclination of 49.6° and 32.6° with 95% confidence limit of 5.4° were determined from 10 samples from kiln KN123. Mean directions from this study were also compared with the directions of the Earth’s magnetic field in Thailand during 1,370 A.D. from the global archaeomagnetic field model ARCH3k.1. Declination and inclination from this study show significant departure from the field predicted by the ARCH3k.1 model.


PEDIATRICS ◽  
1988 ◽  
Vol 81 (1) ◽  
pp. 147-149
Author(s):  
Frederick P. Li ◽  
Wick R. Williams ◽  
Kathreen Gimbrere ◽  
Francoise Flamant ◽  
Daniel M. Green ◽  
...  

Heritability of the unilateral-sporadic (non-familial) form of Wilms tumor was examined in the offspring of 96 long-term survivors of the neoplasm. No Wilms tumor has developed in any of the 179 offspring of these patients. The maximum likelihood estimate of a hereditary Wilms tumor in our patients is zero and the corresponding 95% upper confidence limit ranges between 0.06 and 0.11, depending on penetrance. Among their offspring, the 95% upper bound of the risk of Wilms tumor is 0.02. These figures can be applied in genetic counseling of other survivors of unilateral-sporadic Wilms tumor.


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