Anti-ageing peptides and proteins for topical applications: a review

2021 ◽  
pp. 1-33
Author(s):  
Mengyang Liu ◽  
Shuo Chen ◽  
Zhang Zhiwen ◽  
Hongyu Li ◽  
Guiju Sun ◽  
...  
Keyword(s):  
Topical Applications

Inhibitory Effect of Topical Applications of Nondenatured Soymilk on the Formation and Growth of UVB-Induced Skin Tumors

2004 ◽  
Vol 14 (7) ◽  
pp. 387-397 ◽  
Author(s):  
Mou-Tuan Huang ◽  
Jian-Guo Xie ◽  
Connie B. Lin ◽  
Menas Kizoulis ◽  
Miri Seiberg ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Skin Tumors ◽  
Topical Applications

Nano-Lipidic Carriers as a Tool for Drug Targeting to the Pilosebaceous Units

2020 ◽  
Vol 26 (27) ◽  
pp. 3251-3268
Author(s):  
Shweta Ramkar ◽  
Abhishek K. Sah ◽  
Nagendra Bhuwane ◽  
Ishwari Choudhary ◽  
Narayan Hemnani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hair Follicle ◽  
Hair Follicles ◽  
Prolonged Release ◽  
Pilosebaceous Unit ◽  
Tissue Targeting ◽  
Bulge Region ◽  
Drug Reservoir ◽  
Fast Transport ◽  
Topical Applications

The pilosebaceous unit is the triad comprising of hair follicle, arrector pilli muscle, and sebaceous gland. Drug delivery to and through the hair follicles has garnered much attention of the researchers and the hair follicles represent an attractive target site via topical applications. They are bordered by capillaries and antigenpresenting cells, connected to the sebaceous glands and the bulge region of the hair follicle anchors the stem cells. The nano lipid carriers have the propensity to penetrate through the skin via transcellular route, intracellular route and follicular route. It has been established that nano lipid carriers have the potential for follicular drug delivery and provide some advantages over conventional pathways, including improved bioavailability, enhanced penetration depth, fast transport into the skin, tissue targeting and form a drug reservoir for prolonged release. This review describes the pilosebaceous unit (PSU) and related diseases and the recent lipid-based nanotechnology approaches for drug delivery to the follicular unit as well as related issues. Different types of nano lipid carriers, including ethosomes, liposomes, nanoparticles, solid lipid nanoparticles (SLNs), and nano lipid carriers (NLCs) have been reported for follicular drug delivery. Targeted drug delivery with nano-lipid carriers has the potential to augment the efficacy of drugs/bioactives to treat diseases of PSU. This review systematically introduces the activities of different formulations and the use of nano lipid carriers in treating PSU related disorders like alopecia, acne, and hirsutism.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

Objective evaluation of the efficacy of daily topical applications of cosmetics bases using the hairless mouse model of atopic dermatitis

2005 ◽  
Vol 11 (3) ◽  
pp. 209-217 ◽  
Author(s):  
Katsuo Matsumoto ◽  
Koji Mizukoshi ◽  
Midori Oyobikawa ◽  
Hiroshi Ohshima ◽  
Yuji Sakai ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Model ◽  
Objective Evaluation ◽  
Hairless Mouse ◽  
Topical Applications

Aggressive periodontitis of the primary dentition associated with idiopathic immune deficiency: case report and treatment considerations

2005 ◽  
Vol 29 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Enrique Bimstein ◽  
Michael McIlwain ◽  
Joseph Katz ◽  
Greg Jerrell ◽  
Robert Primosch
Keyword(s):  
Immune Deficiency ◽  
Case Report ◽  
Primary Teeth ◽  
Aggressive Periodontitis ◽  
Primary Dentition ◽  
Permanent Teeth ◽  
Gingival Inflammation ◽  
Adequate Treatment ◽  
Treatment Considerations ◽  
Topical Applications

The present case, of a child with an idiopathic immune deficiency and aggressive periodontitis in the primary dentition, serves as an example for the treatment considerations in these cases. Extraction of all the primary teeth proved to be the most adequate treatment. It allowed the child to eat properly and prevented unwanted infections that could endanger the life of the child. The newly erupted permanent teeth have been subjected to careful oral hygiene, clorhexidine topical applications, and have mild gingival inflammation and no attachment loss.

Topical applications and perioral dermatitis

2000 ◽  
Vol 41 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Rita Malik ◽  
Christopher J Quirk
Keyword(s):  
Perioral Dermatitis ◽  
Topical Applications

Helping patients who are allergic to lanolin and parabens

1971 ◽  
Vol 9 (6) ◽  
pp. 22-23
Keyword(s):  
Contact Allergy ◽  
Normal Skin ◽  
Contact Hypersensitivity ◽  
Hydroxybenzoic Acid ◽  
Methyl Ethyl ◽  
Butyl Esters ◽  
Eczematous Dermatitis ◽  
Wool Wax ◽  
Topical Applications

The name ‘lanolin’ covers wool fat, wool wax and wool alcohol as well as their various constituents. Lanolin is an emulsifier present in many topical medicaments, such as ointments and creams, and in many cosmetics. ‘Parabens’ is the collective name for the alkyl (methyl, ethyl, propyl and butyl) esters of p-hydroxybenzoic acid used as preservatives in cosmetics and other topical applications, especially creams and lotions: they are amongst the most satisfactory preservatives. Lanolin and parabens are the constituents of the vehicles used for local applications which most frequently cause contact hypersensitivity.1 For example, it has been estimated that about 1–2% of patients with eczema or dermatitis are allergic to lanolin, though such allergy is very rare in people with a normal skin. The possibility of contact allergy should be considered in any case of persistent or recurrent eczematous dermatitis which responds poorly to treatment, and the patient should be patch-tested.

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