Prediction of Lymph Node Status by Analysis of Prognostic Factors and Possible Indications for Elective Axillary Dissection in T1 Breast Cancers

2001 ◽  
Vol 167 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Alfredo Guarnieri, Alessandro Neri, Pier Pa
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Axillary Dissection ◽  
Lymph Node Status ◽  
Breast Cancers ◽  
Node Status

ATL

2012 ◽  
Vol 22 (7) ◽  
pp. 1226-1233 ◽  
Author(s):  
Jang Yoo ◽  
Joon Young Choi ◽  
Seung Hwan Moon ◽  
Duk Soo Bae ◽  
Soo Bin Park ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Fdg Pet ◽  
Tumor Volume ◽  
Metabolic Tumor Volume ◽  
Uterine Cervical Cancer ◽  
Lymph Node Status ◽  
Free Survival ◽  
Node Status

ObjectiveWe compared the prognostic value of volume-based metabolic parameters determined using fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) (18F-FDG PET) (with other prognostic parameters in uterine cervical cancer.MethodsThe subjects were 73 female patients who had an initial diagnosis of uterine cervical cancer and who underwent 18F-FDG PET. Various metabolic or volume-based PET parameters including maximum and average standardized uptake values, metabolic tumor volume, and total lesion glycolysis (TLG) were measured in primary cervical tumors. Survival analysis for disease-free survival or progression-free survival was performed with a Kaplan-Meier method using PET parameters and other clinical variables. For determining independent prognostic factors, Cox regression analysis was performed.ResultsRecurrence or disease progression occurred in 23 patients (31.5%). In univariate analysis, patient age (cutoff, 57 years, P < 0.05), International Federation of Gynecology and Obstetrics stage (P = 0.07), primary tumor size (cutoff, 6.7 cm; P < 0.05), lymph node status on PET (P < 0.005), treatment method (P < 0.01), metabolic tumor volume (cutoff, 82 cm3; P = 0.001), and TLG (cutoff, 7600; P = 0.005) were significant predictors of recurrence or progression. In multivariate analysis, both lymph node status on PET (hazard ratio, 1.042 [negative vs intrapelvic metastasis only], 7.008 [negative vs extrapelvic metastasis]; P < 0.001) and TLG (cutoff, 7600; hazard ratio, 2.981; P < 0.05) were independent prognostic factors for predicting recurrence.ConclusionsIn uterine cervical cancer, TLG, a volume-based metabolic parameter, and lymph node status on PET may be significant independent prognostic factors for event-free survival.

scholarly journals Prognostic factors for pulmonary large-cell neuroendocrine carcinoma: a competing-risks analysis

2019 ◽  
Author(s):  
Qian Huang ◽  
Jie Liu ◽  
Qiao Huang ◽  
Huifang Cai ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Function Analysis ◽  
Univariate Analysis ◽  
Large Cell ◽  
Tnm Stage ◽  
Lymph Node Status ◽  
Ajcc Stage ◽  
Node Status ◽  
N3 Lymph Node

Abstract Background Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and highly invasive subtype of lung cancer that accounts for fewer than 3% of cases. The prognostic factors for pulmonary LCNEC are unclear in the literature. Methods Patients diagnosed with pulmonary LCNEC between 2004 and 2015 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The CumIncidence function was used for the univariate analysis. Multivariate analysis was performed using Cox regression analysis, subdistribution hazard function analysis, and cause-specific hazard function analysis. Results We finally screened 1246 patients diagnosed with pulmonary LCNEC, among whom 796 died of LCNEC and 141 died from other causes. The univariate analysis showed that sex, primary site, laterality, American Joint Committee on Cancer (AJCC) stage, T stage, N stage, M stage, lymph-node status, surgery, and chemotherapy were significant prognostic factors for pulmonary LCNEC (P<0.05). The multivariate analysis demonstrated that sex, AJCC stage, TNM stage T4, TNM stage N3, lymph-node status, surgery, and chemotherapy were independent risk factors for the prognosis (P<0.05). Conclusion We have conducted a competing-risks analysis of patients with pulmonary LCNEC in the SEER database. The results showed that sex, AJCC stage, TNM stage T4, TNM stage N3, lymph-node status, surgery, and chemotherapy are independent prognostic factors for pulmonary LCNEC patients. The reported data represent reference information that can be used for accurate assessments of the prognosis of pulmonary LCNEC patients.

scholarly journals Excision margins and sentinel lymph node status as prognostic factors in thick melanoma of the head and neck: A retrospective analysis

Head & Neck ◽  
2016 ◽  
Vol 38 (9) ◽  
pp. 1373-1379 ◽  
Author(s):  
Olivia Ruskin ◽  
Alexandra Sanelli ◽  
Alan Herschtal ◽  
Angela Webb ◽  
Ben Dixon ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Lymph Node Status ◽  
Node Status ◽  
Excision Margins ◽  
Thick Melanoma ◽  
Sentinel Lymph Node Status

scholarly journals Can Tumor-Infiltrating Lymphocytes (TILs) Be a Predictive Factor for Lymph Nodes Status in Both Early Stage and Locally Advanced Breast Cancer?

2019 ◽  
Vol 8 (4) ◽  
pp. 545 ◽  
Author(s):  
Alexandra Caziuc ◽  
Diana Schlanger ◽  
Giorgiana Amarinei ◽  
George Calin Dindelegan
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Early Stage ◽  
Locally Advanced ◽  
Lymph Node Status ◽  
Breast Cancers ◽  
Axillary Clearance ◽  
Node Status ◽  
Response To Chemotherapy

The status of axillary lymph nodes is an important prognostic factor in the outcome of breast cancer tumors. New trials changed the attitude towards axillary clearance. In the era of development of new immune therapies for breast cancer, it is important to identify a biomarker that can predict lymph node status. Tumor-infiltrating lymphocytes (TILs) are a valuable indicator of the immune microenvironment that plays the central role in new anticancer drugs. Although the correlation between TILs and response to chemotherapy was established by previous studies, our retrospective study investigated the correlation between TILs and lymph node status. We analyzed data on 172 patients. According to stage, patients were divided in two groups: patients who underwent primary surgical treatment (breast-conserving or mastectomy and sentinel lymph node (SLN) biopsy +/− axillary clearance in conformity with lymph node status) and patients who received chemotherapy prior to surgical treatment (breast-conserving or mastectomy + axillary clearance). We showed a good inverse correlation between TILs and lymph nodes status for both early stage and locally advanced breast cancers. Moreover, TILs are a predictor for positive lymph nodes in the axilla in patients undergoing axillary clearance after SLN biopsy, with no statistical difference between the intrinsic or histological subtype of breast cancers. We also obtained a significant correlation between TILs and response to chemotherapy with no significative difference according to histological subtype. Although further data have still to be gathered before meeting the criteria for clinical utility, this study demonstrates that TILs are one of the most accredited forthcoming biomarkers for breast cancer (BC) patients.

Impact of Preoperative CA 15-3 Levels in Operable Breast Cancer. Comparison with Tissue Polypeptide Antigen (TPA) and Carcinoembryonic Antigen (CEA)

1991 ◽  
Vol 6 (1) ◽  
pp. 21-24 ◽  
Author(s):  
R.V. Iaffaioli ◽  
F. Caponigro ◽  
G. Esposito ◽  
C. Pagliarulo ◽  
S. Deplacido ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Carcinoembryonic Antigen ◽  
Tumor Size ◽  
Operable Breast Cancer ◽  
Lymph Node Status ◽  
Tissue Polypeptide Antigen ◽  
Node Status ◽  
Similar Association

CA 15-3, TPA and CEA were assayed before surgery in 60 patients with breast cancer. A significant association was found between preoperative CA 15-3 levels and some of the most important prognostic factors in breast cancer, such as lymph node status and tumor size. No similar association was discovered for CEA and TPA. Preoperative CA 15-3 levels were also significantly associated with early recurrences of the disease, thus adding useful information to prognosis especially in N + patients.

scholarly journals Vulvar cancer: Patterns of recurrence and clinicopathological prognostic factors involved in recurrent cases

2016 ◽  
Author(s):  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Vulvar Cancer ◽  
Resection Margins ◽  
Lymph Node Status ◽  
Depth Of Invasion ◽  
Nodal Involvement ◽  
Lateral Lymph Node ◽  
Node Status ◽  
Patterns Of Recurrence

Objective: Vulvar cancer is a rare disease, with an incidence of 0.6% of all female malignancies. With the advances in management of carcinoma vulva to individualisation of treatment to reduce the psychosexual impact an aggressive treatment can have, it is imperative to understand the patterns of recurrence and the common prognostic factors involved. The aim of this study was to determine prognostic variables for recurrence and survival and to identify patterns of recurrence in patients with vulvar cancer. Materials and Methods: All patients (n=87) with primary vulvar cancer treated at the Rajiv Gandhi Cancer Institute between January, 2006 to January, 2015 who underwent surgery were retrospectively analysed regarding the prognostic relevance of different clinicopathological variables. Recurrences were evaluated with regard to their characteristics and localisation and the variables associated with them were analyzed. Results: Age, stage of tumor, size of tumor, location of tumor (central or lateral), lymph node metastasis, depth of invasion and involvement of resection margins, associated intraepithelial abnormality predicted disease-free and overall survival. In multivariate analysis, lymph node status and positive margin status was the most important independent prognostic factor (p = 0.002). Irrespective of the initial nodal involvement, recurrences occurred primarily in the vulvar region. Conclusion: Inguinofemoral lymph node status and adequate margins at initial diagnosis is of critical prognostic importance for patients with vulvar cancer. Further tumour biological characteristics need to be identified to stratify patients with nodal involvement for adjuvant radiotherapy of the vulva to prevent local recurrences.

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