MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Abstract Objectives: Suicide in the elderly is a complex and significant public health problem. The purpose of our study was to examine the role of loneliness and social integration as potential mediators in the relationship between physical pain and suicidal ideation in the elderly. Design: Descriptive, bivariate correlations, and moderated mediation analyses were performed. Setting: Personal meetings were held with participants in their homes. Participants: A total of 198 elderly men aged 65 and over. Measurements: Self-report measures: Beck Scale for Suicidal Ideation, Physical pain subscale, Multidimensional Social Integration in Later Life Scale, and University of California, Los Angeles (UCLA) Loneliness Scale (Version 3). Results: Our findings showed that the association between physical pain and suicidal ideation was mediated by loneliness and social integration. Further analyses revealed that this mediation model was significant among single, but not married, men. Conclusions: Physical pain and social factors are both important in understanding suicidality in late life. Elderly single men who experience physical pain may be lonelier and less socially integrated, and these factors may contribute to higher risk of suicidal ideation.

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Suicidal Ideation in Major Depression: Sex Differences and Impact of Comorbid Anxiety

The Canadian Journal of Psychiatry ◽

10.1177/070674370004500906 ◽

2000 ◽

Vol 45 (9) ◽

pp. 822-826 ◽

Cited By ~ 38

Author(s):

Ayal Schaffer ◽

Anthony J Levitt ◽

R Michael Bagby ◽

Sidney H Kennedy ◽

Robert D Levitan ◽

...

Keyword(s):

Sex Differences ◽

Suicidal Ideation ◽

Major Depression ◽

Comorbid Anxiety

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Suicidal Ideation in Parkinson's Disease

CNS Spectrums ◽

10.1017/s109285290002040x ◽

2009 ◽

Vol 14 (8) ◽

pp. 431-436 ◽

Cited By ~ 21

Author(s):

Arthur Kummer ◽

Francisco Cardoso ◽

Antonio Lucio Teixeira

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Suicidal Ideation ◽

Major Depression ◽

Attempted Suicide ◽

Rating Scale ◽

Suicide Attempts ◽

Disease Onset ◽

Mini Mental Status Exam ◽

Hamilton Rating Scale

ABSTRACTObjective: To assess the frequency of suicidal ideation and suicide attempts in patients with Parkinson's disease.Methods: The Mini International Neuropsychiatric Interview (MINI), Beck Depression Inventory (BDI), and Hamilton Rating Scale for Depression (HAM-D) were administered to 90 consecutive, non-demented Parkinson's disease patients. They were also submitted to a complete neurologic examination which included brief cognitive batteries, the Mini Mental Status Exam, and Frontal Assessment Battery. We analyzed the scores of the section of the MINI related to the risk of suicide as well as the specific questions of BDI and HAM-D concerning suicidal ideation.Results: No patient had ever attempted suicide. According to MINI, suicidal ideation was present in 13 patients (14.4%) with Parkinson's disease. All instruments assessed the risk of suicide in a similar way. Suicidal ideation was associated only with lower age (P=.022), lower age of Parkinson's disease onset (P=.021), panic disorder (P=.004), social anxiety disorder (P=.007), and major depression (P<.001). Logistic regression analysis indicated that major depression was the main predictor of suicidal ideation.Conclusion: Suicide attempts seem to be uncommon in Parkinson's disease, despite the fact that the rates of suicidal ideation are possibly elevated. Depression seems to be the most important predictor of suicidal ideation in Parkinson's disease.

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Response of Depressive Symptoms to Nortriptyline, Phenelzine and Placebo

The British Journal of Psychiatry ◽

10.1192/bjp.151.1.102 ◽

1987 ◽

Vol 151 (1) ◽

pp. 102-106 ◽

Cited By ~ 35

Author(s):

Anastasios Georgotas ◽

Robert E. Mccue ◽

Eitan Friedman ◽

Thomas B. Cooper

Keyword(s):

Depressive Symptoms ◽

Suicidal Ideation ◽

Major Depression ◽

Diurnal Variation ◽

Symptoms Of Depression ◽

Diurnal Variation Of Mood ◽

Better Than

The effects of nortriptyline, phenelzine, and placebo on 13 symptoms of depression were compared in 75 patients, aged 55 or over, who were suffering from major depression. Nortriptyline and phenelzine were more effective than placebo in treating depression mood, guilt feelings, suicidal ideation, agitation, anxiety, loss of energy, and a.m. diurnal variation of mood. Nortriptyline was better than phenelzine or placebo in improving middle/late insomnia. Most of the symptoms did not show significant improvement until the fourth week of treatment.

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