scholarly journals Ficus deltoidea promotes bone formation in streptozotocin-induced diabetic rats

2021 ◽  
Vol 59 (1) ◽  
pp. 66-73
Author(s):  
Nurdiana Samsulrizal ◽  
Yong-Meng Goh ◽  
Hafandi Ahmad ◽  
Sulaiman Md Dom ◽  
Nur Syimal’ain Azmi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Diabetic Rats ◽  
Ficus Deltoidea

scholarly journals Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 20 (16) ◽  
pp. 3964 ◽  
Author(s):  
Wan Gong ◽  
Naidan Zhang ◽  
Gang Cheng ◽  
Quanlong Zhang ◽  
Yuqiong He ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Signaling Pathways ◽  
Bone Microarchitecture ◽  
Diabetic Rats ◽  
Mtor Pathway ◽  
Mtor Signaling ◽  
Rehmannia Glutinosa ◽  
Mineral Density ◽  
Rehmannia Glutinosa Libosch

Rehmanniae Radix Praeparata (RR, named as Shudihuang in traditional Chinese medicine), the steamed roots of Rehmannia glutinosa Libosch (Scrophulariaceae), has been demonstrated to have anti-diabetic and anti-osteoporotic activities. This study aimed to explore the protective effect and underlying mechanism of RR on diabetes-induced bone loss. It was found that RR regulated the alkaline phosphatase activity and osteocalcin level, enhanced bone mineral density, and improved the bone microarchitecture in diabetic rats. The catalpol (CAT), acteoside (ACT), and echinacoside (ECH) from RR increased the proliferation and differentiation of osteoblastic MC3T3-E1 cells injured by high glucose and promoted the production of IGF-1 and expression of related proteins in BMP and IGF-1/PI3K/mammalian target of rapamycin complex 1 (mTOR) signaling pathways. The verifying tests of inhibitors of BMP pathway (noggin) and IGF-1/PI3K/mTOR pathway (picropodophyllin) and molecular docking of IGF-1R further indicated that CAT, ACT, and ECH extracted from RR enhanced bone formation by regulating IGF-1/PI3K/mTOR signaling pathways. These findings suggest that RR may prove to be a promising candidate drug for the prevention and treatment of diabetes-induced osteoporosis.

Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats

Bone ◽  
1997 ◽  
Vol 21 (2) ◽  
pp. 147-153 ◽  
Author(s):  
S. Bain ◽  
N.S. Ramamurthy ◽  
T. Impeduglia ◽  
S. Scolman ◽  
L.M. Golub ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats

scholarly journals Increased BMSC Exosomal miR-140-3p Alleviates Bone Degradation and Promotes Bone Restoration by Targeting Plxnb1 in Diabetic Rats

2021 ◽  
Author(s):  
Ning Wang ◽  
Xuanchen Liu ◽  
Zhen Tang ◽  
Xinghui Wei ◽  
Hui Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Diabetic Rats ◽  
Osteogenic Potential ◽  
Bone Degradation ◽  
Defect Repair

Abstract Background: Diabetes mellitus (DM) is considered to be an important factor for bone degeneration disorders such as bone defect nonunion, which is characterized by physical disability and tremendous economy cost to families and society. Exosomal miRNAs of BMSCs have been reported to participate in osteoblastogenesis and modulating bone formation. However, their impacts on the development of bone degeneration in DM are not yet known. The role of miRNAs in BMSCs exosomes on regulating hyperglycemia bone degeneration was investigated in the present study. Results: The osteogenic potential in bone defect repair of exosomes derived from diabetes mellitus BMSCs derived exosomes (DM-Exos) were revealed to be lower than that in normal BMSCs derived exosomes (N-Exos) in vitro and in vivo. Here, we demonstrate that miR-140-3p level was significantly altered in exosomes derived from BMSCs, ADSCs and serum from DM rats. In in vitro experiments, upregulated miR-140-3p exosomes promoted DM BMSCs differentiation into osteoblasts. The effects were exerted by miR-140-3p targeting plxnb1, plexin B1 is the receptor of semaphoring 4D(Sema4D) that inhibited osteocytes differentiation, thereby promoting bone formation. In DM rats with bone defect, miR-140-3p upregulated exosomes were transplanted into injured bone and accelerated bone regeneration. Besides, miR-140-3p in the exosomes was transferred into BMSCs and osteoblasts and promoted bone regeneration by targeting the plexin B1/RohA/ROCK signaling pathway. Conclusions: Normal-Exos and miR-140-3p overexpressed-Exos accelerated diabetic wound healing by promoting the osteoblastogenesis function of BMSCs through inhibition plexin B1 expression which is the receptor of Sema4D and the plexin B1/RhoA/ROCK pathway compared with diabetes mellitus-Exos. This offers a new insight and a new therapy for treating diabetic bone unhealing.

scholarly journals The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats

2012 ◽  
Vol 9 (5) ◽  
pp. 582 ◽  
Author(s):  
Ali Akhavan ◽  
Zahra Noroozi ◽  
AmirAbbas Shafiei ◽  
Abbas Haghighat ◽  
GholamReza Jahanshahi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Formation ◽  
Vitamin D Supplementation ◽  
Diabetic Rats ◽  
Titanium Implants

Effects of taxifolin on bone formation and apoptosis in experimental periodontitis in diabetic rats

2021 ◽  
pp. 1-9
Author(s):  
Aysan Lektemur Alpan ◽  
Olcay Bakar ◽  
Alper Kızıldağ ◽  
Melih Özdede ◽  
Şenay Topsakal ◽  
...  
Keyword(s):  
Bone Formation ◽  
Diabetic Rats ◽  
Experimental Periodontitis

scholarly journals Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation

2006 ◽  
Vol 85 (6) ◽  
pp. 510-514 ◽  
Author(s):  
R. Liu ◽  
H.S. Bal ◽  
T. Desta ◽  
N. Krothapalli ◽  
M. Alyassi ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Alveolar Bone ◽  
Diabetic Rats ◽  
New Bone Formation ◽  
Periodontal Ligament Fibroblasts ◽  
Zdf Rat ◽  
Pdl Cells ◽  
Periodontal Bone Loss

Using a ligature-induced model in type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabetes primarily affects periodontitis by enhancing bone loss or by limiting osseous repair. Diabetes increased the intensity and duration of the inflammatory infiltrate (P < 0.05). The formation of osteoclasts and percent eroded bone after 7 days of ligature placement was similar, while four days after removal of ligatures, the type 2 diabetic group had significantly higher osteoclast numbers and activity (P < 0.05). The amount of new bone formation following resorption was 2.4- to 2.9-fold higher in normoglycemic vs. diabetic rats (P < 0.05). Diabetes also increased apoptosis and decreased the number of bone-lining cells, osteoblasts, and periodontal ligament fibroblasts (P < 0.05). Thus, diabetes caused a more persistent inflammatory response, greater loss of attachment and more alveolar bone resorption, and impaired new bone formation. The latter may be affected by increased apoptosis of bone-lining and PDL cells.

scholarly journals Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Samsulrizal Nurdiana ◽  
Yong Meng Goh ◽  
Hafandi Ahmad ◽  
Sulaiman Md Dom ◽  
Nur Syimal’ain Azmi ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Diabetic Rats ◽  
Oxidative Status ◽  
Ficus Deltoidea

Effects of locally administered insulin on bone formation in non-diabetic rats

2012 ◽  
Vol 101A (1) ◽  
pp. 132-137 ◽  
Author(s):  
B. Malekzadeh ◽  
P. Tengvall ◽  
L.-O. Öhrnell ◽  
A. Wennerberg ◽  
A. Westerlund
Keyword(s):  
Bone Formation ◽  
Diabetic Rats
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