Istradefylline for the treatment of Parkinson’s disease: is it a promising strategy?

Impairment of autophagy has been strongly implicated in the progressive loss of nigral dopaminergic neurons in Parkinson’s disease (PD). Transcription factor E3 (TFE3), an MiTF/TFE family transcription factor, has been identified as a master regulator of the genes that are associated with lysosomal biogenesis and autophagy. However, whether TFE3 is involved in parkinsonian neurodegeneration remains to be determined. In this study, we found decreased TFE3 expression in the nuclei of the dopaminergic neurons of postmortem human PD brains. Next, we demonstrated that TFE3 knockdown led to autophagy dysfunction and neurodegeneration of dopaminergic neurons in mice, implying that reduction of nuclear TFE3 may contribute to autophagy dysfunction-mediated cell death in PD. Further, we showed that enhancement of autophagy by TFE3 overexpression dramatically reversed autophagy downregulation and dopaminergic neurons loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. Taken together, these findings demonstrate that TFE3 plays an essential role in maintaining autophagy and the survival of dopaminergic neurons, suggesting TFE3 activation may serve as a promising strategy for PD therapy.

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Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease

Journal of Controlled Release ◽

10.1016/j.jconrel.2008.12.010 ◽

2009 ◽

Vol 135 (2) ◽

pp. 119-126 ◽

Cited By ~ 97

Author(s):

E. Garbayo ◽

C.N. Montero-Menei ◽

E. Ansorena ◽

J.L. Lanciego ◽

M.S. Aymerich ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Brain Delivery ◽

Promising Strategy

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v2 ◽

2019 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Positive Attitude ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Promising Strategy ◽

Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and usage continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 190/100,000. Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires.Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001).Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon

Frontiers in Pharmacology ◽

10.3389/fphar.2021.706439 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ana M. Espinosa-Oliva ◽

Pablo García-Miranda ◽

Isabel María Alonso-Bellido ◽

Ana E. Carvajal ◽

Melania González-Rodríguez ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Microglial Activation ◽

Peripheral Inflammation ◽

Ventral Mesencephalon ◽

Predisposing Factor ◽

Promising Strategy ◽

Microglia Polarization ◽

Galectin 3

Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral inflammation, especially the originated in the colon, is emerging as a predisposing factor for suffering this disease. We have largely studied the pleiotropic roles of galectin-3 in driving microglia-associated immune responses. However, studies aimed at elucidating the role of galectin-3 in peripheral inflammation in terms of microglia polarization are lacking. To achieve this, we have evaluated the effect of galectin-3 deletion in two different models of acute peripheral inflammation: intraperitoneal injection of lipopolysaccharide or gut inflammation induced by oral administration of dextran sodium sulfate. We found that under peripheral inflammation the number of microglial cells and the expression levels of pro-inflammatory mediators take place specifically in the dopaminergic system, thus supporting causative links between Parkinson’s disease and peripheral inflammation. Absence of galectin-3 highly reduced neuroinflammation in both models, suggesting an important central regulatory role of galectin-3 in driving microglial activation provoked by the peripheral inflammation. Thus, modulation of galectin-3 function emerges as a promising strategy to minimize undesired microglia polarization states.

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v5 ◽

2020 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Positive Attitude ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Promising Strategy ◽

Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013) .Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease

International Journal of Molecular Sciences ◽

10.3390/ijms222212570 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12570

Author(s):

Sajad Fakhri ◽

Sadaf Abdian ◽

Seyede Nazanin Zarneshan ◽

Esra Küpeli Akkol ◽

Mohammad Hosein Farzaei ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Secondary Metabolites ◽

Neurological Disorders ◽

Plant Secondary Metabolites ◽

Oxygen Species ◽

Genetic Changes ◽

Promising Strategy ◽

Line Plant ◽

Neuroprotective Therapies

Parkinson’s disease (PD) is one of the most prevalent and debilitating neurodegenerative conditions, and is currently on the rise. Several dysregulated pathways are behind the pathogenesis of PD; however, the critical targets remain unclear. Accordingly, there is an urgent need to reveal the key dysregulated pathways in PD. Prevailing reports have highlighted the importance of mitochondrial and cross-talked mediators in neurological disorders, genetic changes, and related complications of PD. Multiple pathophysiological mechanisms of PD, as well as the low efficacy and side effects of conventional neuroprotective therapies, drive the need for finding novel alternative agents. Recently, much attention has been paid to using plant secondary metabolites (e.g., flavonoids/phenolic compounds, alkaloids, and terpenoids) in the modulation of PD-associated manifestations by targeting mitochondria. In this line, plant secondary metabolites have shown promising potential for the simultaneous modulation of mitochondrial apoptosis and reactive oxygen species. This review aimed to address mitochondria and multiple dysregulated pathways in PD by plant-derived secondary metabolites.

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v4 ◽

2020 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Positive Attitude ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Promising Strategy ◽

Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China. Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions ( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education ( P < 0.001) and negatively related to age and PD course ( P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v1 ◽

2019 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Education Standards ◽

Promising Strategy ◽

Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users and the usage has been still growing, however, mobile-health(m-Health) services are currently in the initial stage and have not yet prevailed. Additionally, the prevalence of Parkinson's disease (PD) is 190/100,000 in China, and patients need m-Health to manage their PD. Therefore, this study was designed to determine the attitudes and practicability towards about smartphone applications (APPs) of self-management of chronic condition among the elderly with PD in China.Methods Total 204 participants with PD were selected, from 52 to 87 years, and conducted by attitude surveys concerning using APPs for managing chronic condition via questionnaires.Results Among the total participants, 65.19% subjects had smartphones, and 82.84% ones preferred to use APPs for PD management, who were younger and more frequent web users with higher education standards and better medication compliance as well as longer PD courses and worse conditions of PD, compared with the rest of subjects( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013. Additionally, the preference of patients for the use of the APPs is positively related to education standards( P < 0.001), while negatively related to age and PD course ( P = 0.017, P < 0.001).Conclusion Patients with PD are positive about self-management of smartphone APPs in China. Consequently, improving the coverage of smartphones developing practical and handy APPs would become a novel and promising strategy for PD self-management.

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v3 ◽

2020 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Positive Attitude ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Promising Strategy ◽

Initial Stage

Abstract Background China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China. Methods We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions ( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013.) Additionally, the willingness to apply apps for PD self-management was positively related to education ( P < 0.001) and negatively related to age and PD course ( P = 0.017, P < 0.001). Conclusion In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

10.21203/rs.2.15372/v6 ◽

2020 ◽

Author(s):

Jie Hu ◽

Dezhi Yuan ◽

Qiuye Zhao ◽

Xuefei Wang ◽

Xiaotian Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chronic Condition ◽

Positive Attitude ◽

Medication Compliance ◽

Self Management ◽

Smartphone Apps ◽

Smartphone Applications ◽

Promising Strategy ◽

Initial Stage

Abstract Background: China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods: We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results: Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013) .Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001). Conclusion: In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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