Osteolytic metastasis in breast cancer: effective prevention strategies

2020 ◽  
Vol 20 (9) ◽  
pp. 797-811 ◽  
Author(s):  
Chandi C Mandal
Keyword(s):  
Breast Cancer ◽  
Prevention Strategies ◽  
Effective Prevention ◽  
Osteolytic Metastasis ◽  
Effective Prevention Strategies

scholarly journals Sex-Related Differences of Acute and Chronic Pancreatitis in Adults

2021 ◽  
Vol 10 (2) ◽  
pp. 300
Author(s):  
Madeline Drake ◽  
Shah-Jahan M. Dodwad ◽  
Joy Davis ◽  
Lillian S. Kao ◽  
Yanna Cao ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
The United States ◽  
Prevention Strategies ◽  
Endoscopic Retrograde ◽  
Effective Prevention ◽  
Type 1 Autoimmune Pancreatitis ◽  
Acute And Chronic Pancreatitis ◽  
Effective Prevention Strategies

The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacco-related AP and CP, hypercalcemic AP, hypertriglyceridemic AP, malignancy-related AP, and type 1 autoimmune pancreatitis (AIP). No significant sex-related differences have been reported in medication-induced AP or type 2 AIP. Whether post-endoscopic retrograde cholangiopancreatography pancreatitis is sex-associated remains controversial. Animal models have demonstrated sex-related differences in the rates of induction and severity of AP, CP, and AIP. Animal and human studies have suggested that a combination of risk factor profiles, as well as genes, may be responsible for the observed differences. More investigation into the sex-related differences of AP and CP is desired in order to improve clinical management by developing effective prevention strategies, diagnostics, and therapeutics.

Canakinumab for secondary prevention of coronary artery disease

2021 ◽  
Author(s):  
Luis Ortega-Paz ◽  
Davide Capodanno ◽  
Dominick J Angiolillo
Keyword(s):  
Secondary Prevention ◽  
Outcome Study ◽  
Prevention Strategies ◽  
Effective Prevention ◽  
New Era ◽  
Development Status ◽  
The Cantos ◽  
Artery Disease ◽  
Effective Prevention Strategies

Cardiovascular disease manifestations (CVD) are the world's leading cause of death, and their impact on morbidity requires effective prevention strategies of recurrent adverse events. For decades, inflammation has been proposed as a key promoter for atherosclerosis and its complications. However, studies on the use of drugs to target the excess inflammation in CVD are limited. In 2017, the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial confirmed the key role of inflammation on atherosclerotic disease. Canakinumab is a monoclonal antibody that blocks an inflammatory pathway mediated by IL-1β. The results of the CANTOS trial opened a new era of investigating new therapeutics targeting inflammation for CVD secondary prevention. This review presents the canakinumab's pharmacology, current clinical development status and regulatory perspectives.

scholarly journals Prevention of Sepsis in Children: A New Paradigm for Public Policy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Carley Riley ◽  
Derek S. Wheeler
Keyword(s):  
Causes Of Death ◽  
Healthcare Quality ◽  
Global Burden ◽  
Prevention Strategies ◽  
New Paradigm ◽  
Effective Prevention ◽  
Global Priority ◽  
The World ◽  
Important Means ◽  
Effective Prevention Strategies

Sepsis is one of the leading causes of death worldwide. While the management of critically ill patients with sepsis is certainly better now compared to 20 years ago, sepsis-associated mortality remains unacceptably high. Annual deaths from sepsis in both children and adults far surpass the number of deaths from acute myocardial infarction (AMI), stroke, or cancer. Given the substantial toll that sepsis takes worldwide, prevention of sepsis remains a global priority. Multiple effective prevention strategies exist. Antibiotic prophylaxis, immunizations, and healthcare quality improvement initiatives are important means through which we may reduce the morbidity and mortality from sepsis around the world. Inclusion of these strategies in a coordinated and thoughtful campaign to reduce the global burden of sepsis is necessary for the improvement of pediatric health worldwide.

scholarly journals Biomecânica e Traumatologia do Boxe

2021 ◽  
Vol 12 (6) ◽  
pp. 10-12
Author(s):  
Pedro Martins Farinha ◽  
◽  
Diogo Lino Moura ◽  
Keyword(s):  
Head And Neck ◽  
Olympic Games ◽  
Neck Injuries ◽  
Prevention Strategies ◽  
Severe Injuries ◽  
Effective Prevention ◽  
Amateur Boxing ◽  
Professional Boxing ◽  
Effective Prevention Strategies ◽  
The Olympic Games

Amateur boxing practiced at the Olympic Games has been evolving in conditions of safety for its athletes. The most common injuries are head wounds and lacerations, brain concussions and fractures. However, professional boxing has not kept up with this trend of revising rules and promoting greater safety, turning their athletes prone to severe injuries, especially head and neck injuries. The knowledge of epidemiology and biomechanics of boxing injuries may allow athletes and coaches to anticipate injuries and adopt effective prevention strategies.

scholarly journals Characteristics of falls in mild and moderate Alzheimer's disease

2009 ◽  
Vol 3 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Eliane Mayumi Kato-Narita ◽  
Marcia Radanovic
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Fall Risk ◽  
Environmental Risks ◽  
Prevention Strategies ◽  
Effective Prevention ◽  
Fall Risk Factors ◽  
Functional Stimulation ◽  
Increasing Risk ◽  
Effective Prevention Strategies

Abstract The occurrence of falls in AD patients is frequent, and their consequences are cognitive decline, fractures and loss of independence. Many studies have addressed fall risk factors in order to establish effective prevention strategies. Objectives: We describe the frequency and characteristics of falls in a sample of AD patients and their main risk factors. Methods: We evaluated 40 subjects without cognitive impairment, and 45 AD patients, graded as CDR 1 and CDR 2. Results: Environmental hazard risks were the most frequent cause associated with falls in CDR 1 (41.4%) and CDR 2 (46.7%). Instability (31%) and dizziness (17.2%) were frequent causes of falls in the CDR 1 group, and this group showed the highest rate of recurrence (28%). In both groups of AD patients, indoors falls predominated (70.3 and 80% respectively for CDR 1 and 2). In our sample, the remaining factors studied were not associated with increasing risk for falls. Conclusions: These results reinforce the hypothesis that falls in AD are mutifactorial and that their risk factors are highly interconnected. Preventative strategies considering all aspects should be implemented most crucially eliminating environmental risks, maintaining constant presence of caregivers, and providing physical and functional stimulation, both in mild and moderate AD.

scholarly journals Excessive gaming behaviour in primary school children in Belgium

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
G Van Hal ◽  
J Niemann ◽  
A Van Hiel ◽  
S Van Dongen
Keyword(s):  
Primary School ◽  
School Children ◽  
Sugar Content ◽  
Primary School Children ◽  
Public Health Issue ◽  
Prevention Strategies ◽  
Effective Prevention ◽  
Frequent Consumption ◽  
Effective Prevention Strategies ◽  
Excessive Gaming

Abstract Background The use of electronic devices (smartphones, laptops,...) has gradually become a common activity among primary school children. Especially children's excessive use of elec-tronic games has been increasingly considered an important Public Health issue. This study explored the effects of personal and social factors on gaming behaviour in primary school children. Methods A survey was conducted in primary school children in Flanders (Belgium), 2016. Overall 8,444 children, mainly 9 to 11 years old, were included. First, descriptive and bivariate analyses were conducted. Subsequently, a multinominal logistic regression was performed to analyse gaming behaviour. Results Overall, 27% (n = 2,277), 25% (n = 2,108), 29% (n = 2,453) and 19% (n = 1,606) of the participating children showed a low, moderate, frequent and very frequent level of gaming behaviour, respectively. Gender differences were statistically significant, with boys showing more moderate, frequent and very frequent gaming behaviour. Further, chances for gaming were higher among children with a more frequent consumption of high sugar content soda, chips and candies. Conclusions More frequent gaming in boys can already be observed in primary school. How-ever, further research is needed to explore the development of this behaviour over longer time periods. Further results might provide useful information for developing effective prevention strategies concerning excessive gaming behaviour among primary school children. Key messages Excessive gaming behaviour is already present in 9 to 11 years old children. It might be useful to develop effective prevention strategies regarding excessive gaming in primary school children.

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