Limitations of ultrasound in diagnosing intrauterine growth restriction in severe preeclampsia

2009 ◽  
pp. 1-6
Author(s):  
Jamie Bastek ◽  
Emmanuelle Pare ◽  
Eileen Wang ◽  
Michal Elovitz ◽  
Sindhu Srinivas
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Intrauterine Growth

scholarly journals The association of antenatal D-dimer and fibrinogen with postpartum hemorrhage and intrauterine growth restriction in preeclampsia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hailing Shao ◽  
Shichu Gao ◽  
Dongru Dai ◽  
Xiaomin Zhao ◽  
Ying Hua ◽  
...  
Keyword(s):  
Postpartum Hemorrhage ◽  
Plasma Levels ◽  
Intrauterine Growth Restriction ◽  
Odds Ratio ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Singleton Pregnancy ◽  
Intrauterine Growth ◽  
Mild Preeclampsia ◽  
D Dimer

Abstract Background D-dimer and fibrinogen were verified to be altered in preeclampsia. This study was to evaluate the associations of D-dimer and fibrinogen plasma levels with postpartum hemorrhage or intrauterine growth restriction in preeclamptic women. Methods This was a retrospective study that recruited 278 preeclamptic women with singleton pregnancy from January 2016 to December 2019. Patients were allocated into five groups: mild preeclampsia (mPE) (n=68), mild preeclampsia with postpartum hemorrhage (mPE+PPH) (n=13), severe preeclampsia (sPE) (n=112), severe preeclampsia with postpartum hemorrhage (sPE+PPH) (n=17) and severe preeclampsia with intrauterine growth restriction (sPE+IUGR) (n=68). The antenatal D-dimer and fibrinogen plasma levels were analyzed among the groups. Logistic regression was used to determine the correlation between serum indexes and PPH or IUGR in preeclampsia. Results The antenatal D-dimer plasma levels were significantly higher in the sPE+PPH group than that in the sPE group (2.02 μg/ml versus 1.37 μg/ml, P = 0.001), but there was no difference in fibrinogen. Elevated D-dimer was associated with PPH among severe preeclamptic women (adjusted odds ratio (aOR) [95% CI]: 3.093 [1.527-6.264], P = 0.002). No differences in D-dimer and fibrinogen were found between the mPE and mPE+PPH groups or between the sPE and sPE+IUGR groups. Conclusions Elevated antenatal plasma D-dimer level may be associated with postpartum hemorrhage in severe preeclampsia, but not with intrauterine growth restriction. Future prospective clinical trials are needed to investigate the predictive value of D-dimer in postpartum hemorrhage in severe preeclampsia.

Limitations of ultrasound in diagnosing intrauterine growth restriction in severe preeclampsia

2009 ◽  
Vol 22 (11) ◽  
pp. 1039-1044 ◽  
Author(s):  
Jamie A. Bastek ◽  
Emmanuelle Paré ◽  
Eileen Wang ◽  
Michal A. Elovitz ◽  
Sindhu K. Srinivas
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Intrauterine Growth

Prevalence and Significance of Persistently Positive Antiphospholipid Antibodies in Women with Preeclampsia

2014 ◽  
Vol 42 (2) ◽  
pp. 210-213
Author(s):  
Cristina Gonzalez-Echavarri ◽  
Irama Villar ◽  
Amaia Ugarte ◽  
Rosa Larrieta ◽  
Guillermo Ruiz-Irastorza
Keyword(s):  
Risk Factors ◽  
Intrauterine Growth Restriction ◽  
Antiphospholipid Antibodies ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Obstetric Outcomes ◽  
Clinical Variables ◽  
Intrauterine Growth ◽  
Severity Criteria

Objective.To determine the prevalence of antiphospholipid antibodies (aPL) and their association with obstetric outcomes in women with preeclampsia.Methods.The study included 150 patients. Clinical variables, risk factors, and severity criteria for preeclampsia and aPL were analyzed.Results.We found aPL in 4% of patients without risk factors for preeclampsia and in no women with risk factors (p = 0.03). Fifty percent of aPL-positive patients had a fetus with intrauterine growth restriction versus 13.9% (p = 0.04). No relation between aPL and severe preeclampsia was found.Conclusion.The prevalence of aPL among women with preeclampsia is low. aPL can predispose women without risk factors to preeclampsia.

Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms

2017 ◽  
Vol 45 (7) ◽  
Author(s):  
Jaana Nevalainen ◽  
Sini Skarp ◽  
Eeva-Riitta Savolainen ◽  
Markku Ryynänen ◽  
Jouko Järvenpää
Keyword(s):  
Gene Expression ◽  
Early Onset ◽  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Coagulation Cascade ◽  
Chorionic Villus Sampling ◽  
Hypergeometric Test ◽  
Intrauterine Growth

AbstractObjective:To evaluate placental gene expression in severe early- or late-onset preeclampsia with intrauterine growth restriction compared to controls.Study design:Chorionic villus sampling was conducted after cesarean section from the placentas of five women with early- or late-onset severe preeclampsia and five controls for each preeclampsia group. Microarray analysis was performed to identify gene expression differences between the groups.Results:Pathway analysis showed over-representation of gene ontology (GO) biological process terms related to inflammatory and immune response pathways, platelet development, vascular development, female pregnancy and reproduction in early-onset preeclampsia. Pathways related to immunity, complement and coagulation cascade were overrepresented in the hypergeometric test for the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Ten genes (Conclusion:There are significant differences in placental gene expression between severe early- and late-onset preeclampsia when both are associated with intrauterine growth restriction.

scholarly journals HOW TO MANAGE INTRAUTERINE GROWTH RESTRICTION ASSOCIATED WITH SEVERE PREECLAMPSIA AT 28-34 WEEKS OF GESTATION?

2008 ◽  
Vol 5 (4) ◽  
Author(s):  
Kazım Gezginç ◽  
Ali Acar ◽  
Harun Peru ◽  
Rengin Karataylı ◽  
Çetin Çelik ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Severe Preeclampsia ◽  
Intrauterine Growth

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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