ZSCAN16-AS1 expedites hepatocellular carcinoma progression via modulating the miR-181c-5p/SPAG9 axis to activate the JNK pathway

Cell Cycle ◽  
2021 ◽  
pp. 1-13
Author(s):  
Jianwen Liu ◽  
Ruiqing Liu ◽  
Yuyan Liu ◽  
Lupeng Li ◽  
Huicun Cao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Jnk Pathway

scholarly journals Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma

2020 ◽  
Vol 21 (2) ◽  
pp. 496
Author(s):  
Shahanshah Khan ◽  
Hasan Zaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Critical Role ◽  
Negative Regulation ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Factor ◽  
Inflammatory Signaling ◽  
Jnk Pathway ◽  
Mitogen Activated Protein ◽  
Molecular Patterns

Hepatocellular carcinoma (HCC), a leading cause of cancer-related death, is initiated and promoted by chronic inflammation. Inflammatory mediators are transcriptionally regulated by several inflammatory signaling pathways, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). cJun N-terminal kinase (JNK), a member of the MAPK family, plays a central role in HCC pathogenesis. Pathogen-associated molecular patterns (PAMPs) activate JNK and other MAPK upon recognition by toll-like receptors (TLRs). Apart from TLRs, PAMPs are sensed by several other pattern recognition receptors, including cytosolic NOD-like receptors (NLRs). In a recent study, we demonstrated that the NLR member NLRP12 plays a critical role in suppressing HCC via negative regulation of the JNK pathway. This article briefly reviews the crosstalk between NLRP12 and JNK that occurs during HCC.

Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway

2015 ◽  
Vol 68 (2) ◽  
pp. 671-683 ◽  
Author(s):  
Yu-Qing Dong ◽  
Chuan-Wei Lu ◽  
Lu Zhang ◽  
Jia Yang ◽  
Waqaar Hameed ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Jnk Pathway ◽  
Hepatocellular Carcinoma Cells

scholarly journals MiR-124 sensitizes cisplatin-induced cytotoxicity against CD133+ hepatocellular carcinoma cells by targeting SIRT1/ROS/JNK pathway

Aging ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2551-2564 ◽  
Author(s):  
Yunxiuxiu Xu ◽  
Yu Lai ◽  
Hanqin Weng ◽  
Lanping Tan ◽  
Yanshan Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Jnk Pathway ◽  
Hepatocellular Carcinoma Cells

scholarly journals Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells

2015 ◽  
Vol 13 (2) ◽  
pp. 1570-1576 ◽  
Author(s):  
RUINIAN ZHENG ◽  
ZHIJIAN YOU ◽  
JUN JIA ◽  
SHUNHUAN LIN ◽  
SHUAI HAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antitumor Effect ◽  
Carcinoma Cells ◽  
Jnk Pathway ◽  
Hepatocellular Carcinoma Cells

Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma

Tumor Biology ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 8219-8227 ◽  
Author(s):  
Po-Li Wei ◽  
Chien-Yu Huang ◽  
Cheng-Jeng Tai ◽  
Uyanga Batzorig ◽  
Wan-Li Cheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Jnk Pathway ◽  
Glucose Regulated Protein
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