scholarly journals Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma

2020 ◽  
Vol 21 (2) ◽  
pp. 496
Author(s):  
Shahanshah Khan ◽  
Hasan Zaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Critical Role ◽  
Negative Regulation ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Factor ◽  
Inflammatory Signaling ◽  
Jnk Pathway ◽  
Mitogen Activated Protein ◽  
Molecular Patterns

Hepatocellular carcinoma (HCC), a leading cause of cancer-related death, is initiated and promoted by chronic inflammation. Inflammatory mediators are transcriptionally regulated by several inflammatory signaling pathways, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). cJun N-terminal kinase (JNK), a member of the MAPK family, plays a central role in HCC pathogenesis. Pathogen-associated molecular patterns (PAMPs) activate JNK and other MAPK upon recognition by toll-like receptors (TLRs). Apart from TLRs, PAMPs are sensed by several other pattern recognition receptors, including cytosolic NOD-like receptors (NLRs). In a recent study, we demonstrated that the NLR member NLRP12 plays a critical role in suppressing HCC via negative regulation of the JNK pathway. This article briefly reviews the crosstalk between NLRP12 and JNK that occurs during HCC.

scholarly journals Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1298
Author(s):  
Hyeon-Hwa Nam ◽  
Joong Sun Kim ◽  
Jun Lee ◽  
Young Hye Seo ◽  
Hyo Seon Kim ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Mitogen Activated Protein Kinase ◽  
Network Pharmacology ◽  
Nuclear Factor ◽  
Pharmacological Effects ◽  
Agastache Rugosa ◽  
Gastric Diseases ◽  
Nuclear Factor Kappa ◽  
Mitogen Activated Protein

Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown. In this study, we aimed to reveal the pharmacological effects of A. rugosa on gastritis by combining a mice model and a network pharmacology method. The macrophage and gastritis-induced models were used to evaluate the pharmacological effects of A. rugosa. The results show that A. rugosa relieved mucosal damage induced by HCl/EtOH in vivo. Network analysis identified 99 components in A. rugosa; six components were selected through systematic screening, and five components were linked to 45 gastritis-related genes. The main components were acacetin and luteolin, and the identified core genes were AKT serine/threonine kinase 1 (AKT1), nuclear factor kappa B inhibitor alpha (NFKBIA), and mitogen-activated protein kinase-3 (MAPK3) etc. in this network. The network of components, target genes, protein–protein interactions, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was closely connected with chemokines and with phosphoinositide 3-kinase-Akt (PI3K/AKT), tumor-necrosis-factor alpha (TNFα), mitogen-activated protein kinase, nuclear factor kappa B, and Toll-like receptor (TLR) pathways. In conclusion, A. rugosa exerts gastro-protective effects through a multi-compound and multi-pathway regulatory network and holds potential for treating inflammatory gastric diseases.

scholarly journals Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Lalita Subedi ◽  
So-Hyeon Baek ◽  
Sun Yeou Kim
Keyword(s):  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Genetically Engineered ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Mitogen Activated Protein ◽  
Inflammatory Proteins

Resveratrol, a natural stilbenoid, is produced by several plants, especially grape vines. Its strong potency against obesity, metabolic disorders, vascular disease, inflammation, and various cancers has already been reported. Large amounts of wine or grapes need to be consumed to obtain the amount of resveratrol required for biological activity. Pure resveratrol at concentrations as low as 10 μM induces cytotoxicity to normal cells. To overcome these limitations, we prepared genetically modified resveratrol-enriched rice (RR). We previously reported the strong antiaging potential of RR against ultraviolet B/reactive oxygen species-induced toxicity in normal human dermal fibroblasts (NHDF). As aging is characterized by neuroinflammation and neurodegeneration, we further evaluated the role of RR against LPS-induced neuroinflammation. RR inhibited nitric oxide production and the expression of inflammatory proteins such as iNOS and COX-2. RR significantly modulated mitogen-activated protein kinase signaling, activator protein AP-1 signaling, and nuclear factor kappa B (NF-κB) mediated transcription of inflammatory proteins via inhibition of NF-κB translocation, IkB phosphorylation, and proinflammatory cytokine productions such as interleukin IL-6, IL-1β, tumor necrosis factor alpha (TNF-α), and prostaglandin E2 (PGE2). These findings show that the strong antineuroinflammatory effects of RR can be beneficial for aging-mediated neurodegenerative conditions as well as disorders of the central nervous system caused by neuroinflammation.

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